Weight Pulling: A Novel Mouse Model of Human Progressive Resistance Exercise
This study describes a mouse model of progressive resistance exercise that utilizes a full-body/multi-joint exercise (weight pulling) along with a training protocol that mimics a traditional human paradigm (three training sessions per week, ~8–12 repetitions per set, 2 min of rest between sets, appr...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-09-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/10/9/2459 |
| _version_ | 1797519852378783744 |
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| author | Wenyuan G. Zhu Jamie E. Hibbert Kuan Hung Lin Nathaniel D. Steinert Jake L. Lemens Kent W. Jorgenson Sarah M. Newman Dudley W. Lamming Troy A. Hornberger |
| author_facet | Wenyuan G. Zhu Jamie E. Hibbert Kuan Hung Lin Nathaniel D. Steinert Jake L. Lemens Kent W. Jorgenson Sarah M. Newman Dudley W. Lamming Troy A. Hornberger |
| author_sort | Wenyuan G. Zhu |
| collection | DOAJ |
| description | This study describes a mouse model of progressive resistance exercise that utilizes a full-body/multi-joint exercise (weight pulling) along with a training protocol that mimics a traditional human paradigm (three training sessions per week, ~8–12 repetitions per set, 2 min of rest between sets, approximately two maximal-intensity sets per session, last set taken to failure, and a progressive increase in loading that is based on the individual’s performance). We demonstrate that weight pulling can induce an increase in the mass of numerous muscles throughout the body. The relative increase in muscle mass is similar to what has been observed in human studies, and is associated with the same type of long-term adaptations that occur in humans (e.g., fiber hypertrophy, myonuclear accretion, and, in some instances, a fast-to-slow transition in Type II fiber composition). Moreover, we demonstrate that weight pulling can induce the same type of acute responses that are thought to drive these long-term adaptations (e.g., the activation of signaling through mTORC1 and the induction of protein synthesis at 1 h post-exercise). Collectively, the results of this study indicate that weight pulling can serve as a highly translatable mouse model of progressive resistance exercise. |
| first_indexed | 2024-03-10T07:48:39Z |
| format | Article |
| id | doaj.art-a8c60c5da2fe40e0b413a2e752c319a0 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T07:48:39Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-a8c60c5da2fe40e0b413a2e752c319a02023-11-22T12:26:31ZengMDPI AGCells2073-44092021-09-01109245910.3390/cells10092459Weight Pulling: A Novel Mouse Model of Human Progressive Resistance ExerciseWenyuan G. Zhu0Jamie E. Hibbert1Kuan Hung Lin2Nathaniel D. Steinert3Jake L. Lemens4Kent W. Jorgenson5Sarah M. Newman6Dudley W. Lamming7Troy A. Hornberger8Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USADepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USADepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USADepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USADepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USADepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USADepartment of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USADepartment of Medicine, University of Wisconsin-Madison, Madison, WI 53705, USADepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USAThis study describes a mouse model of progressive resistance exercise that utilizes a full-body/multi-joint exercise (weight pulling) along with a training protocol that mimics a traditional human paradigm (three training sessions per week, ~8–12 repetitions per set, 2 min of rest between sets, approximately two maximal-intensity sets per session, last set taken to failure, and a progressive increase in loading that is based on the individual’s performance). We demonstrate that weight pulling can induce an increase in the mass of numerous muscles throughout the body. The relative increase in muscle mass is similar to what has been observed in human studies, and is associated with the same type of long-term adaptations that occur in humans (e.g., fiber hypertrophy, myonuclear accretion, and, in some instances, a fast-to-slow transition in Type II fiber composition). Moreover, we demonstrate that weight pulling can induce the same type of acute responses that are thought to drive these long-term adaptations (e.g., the activation of signaling through mTORC1 and the induction of protein synthesis at 1 h post-exercise). Collectively, the results of this study indicate that weight pulling can serve as a highly translatable mouse model of progressive resistance exercise.https://www.mdpi.com/2073-4409/10/9/2459skeletal musclehypertrophymyonuclear accretionprotein synthesissignalinggrowth |
| spellingShingle | Wenyuan G. Zhu Jamie E. Hibbert Kuan Hung Lin Nathaniel D. Steinert Jake L. Lemens Kent W. Jorgenson Sarah M. Newman Dudley W. Lamming Troy A. Hornberger Weight Pulling: A Novel Mouse Model of Human Progressive Resistance Exercise Cells skeletal muscle hypertrophy myonuclear accretion protein synthesis signaling growth |
| title | Weight Pulling: A Novel Mouse Model of Human Progressive Resistance Exercise |
| title_full | Weight Pulling: A Novel Mouse Model of Human Progressive Resistance Exercise |
| title_fullStr | Weight Pulling: A Novel Mouse Model of Human Progressive Resistance Exercise |
| title_full_unstemmed | Weight Pulling: A Novel Mouse Model of Human Progressive Resistance Exercise |
| title_short | Weight Pulling: A Novel Mouse Model of Human Progressive Resistance Exercise |
| title_sort | weight pulling a novel mouse model of human progressive resistance exercise |
| topic | skeletal muscle hypertrophy myonuclear accretion protein synthesis signaling growth |
| url | https://www.mdpi.com/2073-4409/10/9/2459 |
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