Ketamine evoked disruption of entorhinal and hippocampal spatial maps
Abstract Ketamine, a rapid-acting anesthetic and acute antidepressant, carries undesirable spatial cognition side effects including out-of-body experiences and spatial memory impairments. The neural substrates that underlie these alterations in spatial cognition however, remain incompletely understo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-41750-4 |
| _version_ | 1797557889182728192 |
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| author | Francis Kei Masuda Emily A. Aery Jones Yanjun Sun Lisa M. Giocomo |
| author_facet | Francis Kei Masuda Emily A. Aery Jones Yanjun Sun Lisa M. Giocomo |
| author_sort | Francis Kei Masuda |
| collection | DOAJ |
| description | Abstract Ketamine, a rapid-acting anesthetic and acute antidepressant, carries undesirable spatial cognition side effects including out-of-body experiences and spatial memory impairments. The neural substrates that underlie these alterations in spatial cognition however, remain incompletely understood. Here, we used electrophysiology and calcium imaging to examine ketamine’s impacts on the medial entorhinal cortex and hippocampus, which contain neurons that encode an animal’s spatial position, as mice navigated virtual reality and real world environments. Ketamine acutely increased firing rates, degraded cell-pair temporal firing-rate relationships, and altered oscillations, leading to longer-term remapping of spatial representations. In the reciprocally connected hippocampus, the activity of neurons that encode the position of the animal was suppressed after ketamine administration. Together, these findings demonstrate ketamine-induced dysfunction of the MEC-hippocampal circuit at the single cell, local-circuit population, and network levels, connecting previously demonstrated physiological effects of ketamine on spatial cognition to alterations in the spatial navigation circuit. |
| first_indexed | 2024-03-10T17:22:42Z |
| format | Article |
| id | doaj.art-a8c83a439d984da69d7b022bb385b229 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-10T17:22:42Z |
| publishDate | 2023-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a8c83a439d984da69d7b022bb385b2292023-11-20T10:17:12ZengNature PortfolioNature Communications2041-17232023-10-0114111910.1038/s41467-023-41750-4Ketamine evoked disruption of entorhinal and hippocampal spatial mapsFrancis Kei Masuda0Emily A. Aery Jones1Yanjun Sun2Lisa M. Giocomo3Department of Neurobiology, Stanford University School of MedicineDepartment of Neurobiology, Stanford University School of MedicineDepartment of Neurobiology, Stanford University School of MedicineDepartment of Neurobiology, Stanford University School of MedicineAbstract Ketamine, a rapid-acting anesthetic and acute antidepressant, carries undesirable spatial cognition side effects including out-of-body experiences and spatial memory impairments. The neural substrates that underlie these alterations in spatial cognition however, remain incompletely understood. Here, we used electrophysiology and calcium imaging to examine ketamine’s impacts on the medial entorhinal cortex and hippocampus, which contain neurons that encode an animal’s spatial position, as mice navigated virtual reality and real world environments. Ketamine acutely increased firing rates, degraded cell-pair temporal firing-rate relationships, and altered oscillations, leading to longer-term remapping of spatial representations. In the reciprocally connected hippocampus, the activity of neurons that encode the position of the animal was suppressed after ketamine administration. Together, these findings demonstrate ketamine-induced dysfunction of the MEC-hippocampal circuit at the single cell, local-circuit population, and network levels, connecting previously demonstrated physiological effects of ketamine on spatial cognition to alterations in the spatial navigation circuit.https://doi.org/10.1038/s41467-023-41750-4 |
| spellingShingle | Francis Kei Masuda Emily A. Aery Jones Yanjun Sun Lisa M. Giocomo Ketamine evoked disruption of entorhinal and hippocampal spatial maps Nature Communications |
| title | Ketamine evoked disruption of entorhinal and hippocampal spatial maps |
| title_full | Ketamine evoked disruption of entorhinal and hippocampal spatial maps |
| title_fullStr | Ketamine evoked disruption of entorhinal and hippocampal spatial maps |
| title_full_unstemmed | Ketamine evoked disruption of entorhinal and hippocampal spatial maps |
| title_short | Ketamine evoked disruption of entorhinal and hippocampal spatial maps |
| title_sort | ketamine evoked disruption of entorhinal and hippocampal spatial maps |
| url | https://doi.org/10.1038/s41467-023-41750-4 |
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