Weizmannia coagulans strain SANK70258 combined with galacto-oligosaccharides reduces fecal-p-cresol content and improves scaliness and skin roughness
In this study, we evaluate the effects of Weizmannia coagulans SANK70258 intake on skin condition and defecation, both alone and in combination with galacto-oligosaccharides, by conducting a randomized, double-blind, parallel-group, placebo-controlled, eight-week study of 45 healthy individuals. The...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-08-01
|
| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464623002657 |
| _version_ | 1827871778836316160 |
|---|---|
| author | Naoyuki Togawa Ryouichi Yamada Kayoko Numano Yoshinori Aoki Shouhei Suehiro Noriyoshi Uchida |
| author_facet | Naoyuki Togawa Ryouichi Yamada Kayoko Numano Yoshinori Aoki Shouhei Suehiro Noriyoshi Uchida |
| author_sort | Naoyuki Togawa |
| collection | DOAJ |
| description | In this study, we evaluate the effects of Weizmannia coagulans SANK70258 intake on skin condition and defecation, both alone and in combination with galacto-oligosaccharides, by conducting a randomized, double-blind, parallel-group, placebo-controlled, eight-week study of 45 healthy individuals. The primary endpoints were measurement of the stratum corneum moisture content, transepidermal water loss, and skin texture; the secondary endpoints were skin assessment, a defecation survey, and measurement of fecal organic acid and p-cresol contents. The participants were divided into a W. coagulans SANK70258 alone (lac + dex) group, a W. coagulans SANK70258 plus galacto-oligosaccharides (lac + gal) group, and a placebo (dex) group. The lac + gal group showed a decrease in skin roughness and fecal p-cresol content. Scaliness was improved in lac + dex and lac + gal groups. Thus, synbiotics combining W. coagulans SANK70258 and galacto-oligosaccharides can improve scaliness and skin roughness and reduce fecal p-cresol content. |
| first_indexed | 2024-03-12T16:15:44Z |
| format | Article |
| id | doaj.art-a8cae56f2bab4e8c996822595f8e3ad4 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-12T16:15:44Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-a8cae56f2bab4e8c996822595f8e3ad42023-08-09T04:32:31ZengElsevierJournal of Functional Foods1756-46462023-08-01107105665Weizmannia coagulans strain SANK70258 combined with galacto-oligosaccharides reduces fecal-p-cresol content and improves scaliness and skin roughnessNaoyuki Togawa0Ryouichi Yamada1Kayoko Numano2Yoshinori Aoki3Shouhei Suehiro4Noriyoshi Uchida5Science & Innovation Center, Mitsubishi Chemical Corporation, Yokohama-shi 227-8502, Japan; Corresponding author at: 1000 Kamoshida-cho, Aoba-ku, Yokohama-shi, Kanagawa 227-8502, Japan.Science & Innovation Center, Mitsubishi Chemical Corporation, Yokohama-shi 227-8502, JapanEbisu Ray Clinic, Shinkoukai Medical Corporation, 1-11-2 Ebisu, Shibuya-ku, Tokyo 150-0013, JapanMitsubishi Chemical Corporation, Tokyo 100-8251, JapanMitsubishi Chemical Corporation, Tokyo 100-8251, JapanMitsubishi Chemical Corporation, Tokyo 100-8251, JapanIn this study, we evaluate the effects of Weizmannia coagulans SANK70258 intake on skin condition and defecation, both alone and in combination with galacto-oligosaccharides, by conducting a randomized, double-blind, parallel-group, placebo-controlled, eight-week study of 45 healthy individuals. The primary endpoints were measurement of the stratum corneum moisture content, transepidermal water loss, and skin texture; the secondary endpoints were skin assessment, a defecation survey, and measurement of fecal organic acid and p-cresol contents. The participants were divided into a W. coagulans SANK70258 alone (lac + dex) group, a W. coagulans SANK70258 plus galacto-oligosaccharides (lac + gal) group, and a placebo (dex) group. The lac + gal group showed a decrease in skin roughness and fecal p-cresol content. Scaliness was improved in lac + dex and lac + gal groups. Thus, synbiotics combining W. coagulans SANK70258 and galacto-oligosaccharides can improve scaliness and skin roughness and reduce fecal p-cresol content.http://www.sciencedirect.com/science/article/pii/S1756464623002657Weizmannia coagulans SANK70258Fecal p-cresolSkin roughnessScalinessGut flora |
| spellingShingle | Naoyuki Togawa Ryouichi Yamada Kayoko Numano Yoshinori Aoki Shouhei Suehiro Noriyoshi Uchida Weizmannia coagulans strain SANK70258 combined with galacto-oligosaccharides reduces fecal-p-cresol content and improves scaliness and skin roughness Journal of Functional Foods Weizmannia coagulans SANK70258 Fecal p-cresol Skin roughness Scaliness Gut flora |
| title | Weizmannia coagulans strain SANK70258 combined with galacto-oligosaccharides reduces fecal-p-cresol content and improves scaliness and skin roughness |
| title_full | Weizmannia coagulans strain SANK70258 combined with galacto-oligosaccharides reduces fecal-p-cresol content and improves scaliness and skin roughness |
| title_fullStr | Weizmannia coagulans strain SANK70258 combined with galacto-oligosaccharides reduces fecal-p-cresol content and improves scaliness and skin roughness |
| title_full_unstemmed | Weizmannia coagulans strain SANK70258 combined with galacto-oligosaccharides reduces fecal-p-cresol content and improves scaliness and skin roughness |
| title_short | Weizmannia coagulans strain SANK70258 combined with galacto-oligosaccharides reduces fecal-p-cresol content and improves scaliness and skin roughness |
| title_sort | weizmannia coagulans strain sank70258 combined with galacto oligosaccharides reduces fecal p cresol content and improves scaliness and skin roughness |
| topic | Weizmannia coagulans SANK70258 Fecal p-cresol Skin roughness Scaliness Gut flora |
| url | http://www.sciencedirect.com/science/article/pii/S1756464623002657 |
| work_keys_str_mv | AT naoyukitogawa weizmanniacoagulansstrainsank70258combinedwithgalactooligosaccharidesreducesfecalpcresolcontentandimprovesscalinessandskinroughness AT ryouichiyamada weizmanniacoagulansstrainsank70258combinedwithgalactooligosaccharidesreducesfecalpcresolcontentandimprovesscalinessandskinroughness AT kayokonumano weizmanniacoagulansstrainsank70258combinedwithgalactooligosaccharidesreducesfecalpcresolcontentandimprovesscalinessandskinroughness AT yoshinoriaoki weizmanniacoagulansstrainsank70258combinedwithgalactooligosaccharidesreducesfecalpcresolcontentandimprovesscalinessandskinroughness AT shouheisuehiro weizmanniacoagulansstrainsank70258combinedwithgalactooligosaccharidesreducesfecalpcresolcontentandimprovesscalinessandskinroughness AT noriyoshiuchida weizmanniacoagulansstrainsank70258combinedwithgalactooligosaccharidesreducesfecalpcresolcontentandimprovesscalinessandskinroughness |