Overexpression of NOX2 Exacerbates AngII-Mediated Cardiac Dysfunction and Metabolic Remodelling

Overexpression of NOX2 Exacerbates AngII-Mediated Cardiac Dysfunction and Metabolic Remodelling

The present study aimed to examine the effects of low doses of angiotensin II (AngII) on cardiac function, myocardial substrate utilization, energetics, and mitochondrial function in C57Bl/6J mice and in a transgenic mouse model with cardiomyocyte specific upregulation of NOX2 (csNOX2 TG). Mice were...

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Bibliographic Details
Main Authors: Synne S. Hansen, Tina M. Pedersen, Julie Marin, Neoma T. Boardman, Ajay M. Shah, Ellen Aasum, Anne D. Hafstad
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Antioxidants
Subjects:
angiotensin II
NOX2
cardiac disease
hypertension
cardiac efficiency
cardiac hypertrophy
Online Access:https://www.mdpi.com/2076-3921/11/1/143

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https://www.mdpi.com/2076-3921/11/1/143

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