Polymorphisms of GSTM1 and GSTT1 genes in breast cancer susceptibility: a case-control study
PURPOSE: This study aimed to evaluate the frequency of homozygous deletion of GSTM1 and GSTT1 genes and their combinations between patients with breast cancer and healthy individuals, associating them with disease susceptibility. METHODS: This is a case-control study in which 49 women diagnosed with...
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| Format: | Article |
| Language: | English |
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Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
2013-12-01
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| Series: | Revista Brasileira de Ginecologia e Obstetrícia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032013001200007&tlng=en |
| _version_ | 1818973103084011520 |
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| author | Lia Gonçalves Possuelo Camila Farias Peraça Michelle Fraga Eisenhardt Marcelo Luis Dotto Lucas Cappelletti Eliara Foletto Andreia Rosane de Moura Valim |
| author_facet | Lia Gonçalves Possuelo Camila Farias Peraça Michelle Fraga Eisenhardt Marcelo Luis Dotto Lucas Cappelletti Eliara Foletto Andreia Rosane de Moura Valim |
| author_sort | Lia Gonçalves Possuelo |
| collection | DOAJ |
| description | PURPOSE: This study aimed to evaluate the frequency of homozygous deletion of GSTM1 and GSTT1 genes and their combinations between patients with breast cancer and healthy individuals, associating them with disease susceptibility. METHODS: This is a case-control study in which 49 women diagnosed with breast cancer confirmed by pathological examination and 49 healthy women with no evidence of cancer and no prior family history of breast cancer were invited to participate. All of them answered a questionnaire with epidemiological data and were submitted to blood sample collection. Genomic DNA was extracted from blood, and genotyping was performed by polymerase chain reaction. Data were analyzed with SPSS 20.0. RESULTS: The frequency of null alleles for GSTM1 and GSTT1 was 58.8 and 61.7%, respectively, for patients with breast cancer, and 41.2 and 38.3%, respectively, in control patients. In homozygous deletion of the GSTM1 gene, a significantly higher frequency was found in the breast cancer cases. CONCLUSION: Breast cancer patients presented higher frequency of homozygous deletion of the GSTM1 gene compared with the control group. |
| first_indexed | 2024-12-20T15:18:50Z |
| format | Article |
| id | doaj.art-a8cdd78996f644508a86e5efbcdeff03 |
| institution | Directory Open Access Journal |
| issn | 0100-7203 |
| language | English |
| last_indexed | 2024-12-20T15:18:50Z |
| publishDate | 2013-12-01 |
| publisher | Federação Brasileira das Sociedades de Ginecologia e Obstetrícia |
| record_format | Article |
| series | Revista Brasileira de Ginecologia e Obstetrícia |
| spelling | doaj.art-a8cdd78996f644508a86e5efbcdeff032022-12-21T19:36:07ZengFederação Brasileira das Sociedades de Ginecologia e ObstetríciaRevista Brasileira de Ginecologia e Obstetrícia0100-72032013-12-01351256957410.1590/S0100-72032013001200007Polymorphisms of GSTM1 and GSTT1 genes in breast cancer susceptibility: a case-control studyLia Gonçalves Possuelo0Camila Farias PeraçaMichelle Fraga EisenhardtMarcelo Luis Dotto1Lucas CappellettiEliara FolettoAndreia Rosane de Moura ValimUniversidade de Santa Cruz do SulHospital Ana NeryPURPOSE: This study aimed to evaluate the frequency of homozygous deletion of GSTM1 and GSTT1 genes and their combinations between patients with breast cancer and healthy individuals, associating them with disease susceptibility. METHODS: This is a case-control study in which 49 women diagnosed with breast cancer confirmed by pathological examination and 49 healthy women with no evidence of cancer and no prior family history of breast cancer were invited to participate. All of them answered a questionnaire with epidemiological data and were submitted to blood sample collection. Genomic DNA was extracted from blood, and genotyping was performed by polymerase chain reaction. Data were analyzed with SPSS 20.0. RESULTS: The frequency of null alleles for GSTM1 and GSTT1 was 58.8 and 61.7%, respectively, for patients with breast cancer, and 41.2 and 38.3%, respectively, in control patients. In homozygous deletion of the GSTM1 gene, a significantly higher frequency was found in the breast cancer cases. CONCLUSION: Breast cancer patients presented higher frequency of homozygous deletion of the GSTM1 gene compared with the control group.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032013001200007&tlng=enBreast neoplasmsBreast neoplasmsGenetic predisposition to diseaseGlutathione transferaseDisease susceptibilityCase-control studies |
| spellingShingle | Lia Gonçalves Possuelo Camila Farias Peraça Michelle Fraga Eisenhardt Marcelo Luis Dotto Lucas Cappelletti Eliara Foletto Andreia Rosane de Moura Valim Polymorphisms of GSTM1 and GSTT1 genes in breast cancer susceptibility: a case-control study Revista Brasileira de Ginecologia e Obstetrícia Breast neoplasms Breast neoplasms Genetic predisposition to disease Glutathione transferase Disease susceptibility Case-control studies |
| title | Polymorphisms of GSTM1 and GSTT1 genes in breast cancer susceptibility: a case-control study |
| title_full | Polymorphisms of GSTM1 and GSTT1 genes in breast cancer susceptibility: a case-control study |
| title_fullStr | Polymorphisms of GSTM1 and GSTT1 genes in breast cancer susceptibility: a case-control study |
| title_full_unstemmed | Polymorphisms of GSTM1 and GSTT1 genes in breast cancer susceptibility: a case-control study |
| title_short | Polymorphisms of GSTM1 and GSTT1 genes in breast cancer susceptibility: a case-control study |
| title_sort | polymorphisms of gstm1 and gstt1 genes in breast cancer susceptibility a case control study |
| topic | Breast neoplasms Breast neoplasms Genetic predisposition to disease Glutathione transferase Disease susceptibility Case-control studies |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032013001200007&tlng=en |
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