Tumor Necrosis Factor (TNF) Is Required for Spatial Learning and Memory in Male Mice under Physiological, but Not Immune-Challenged Conditions

Tumor Necrosis Factor (TNF) Is Required for Spatial Learning and Memory in Male Mice under Physiological, but Not Immune-Challenged Conditions

Increasing evidence demonstrates that inflammatory cytokines—such as tumor necrosis factor (TNF)—are produced at low levels in the brain under physiological conditions and may be crucial for synaptic plasticity, neurogenesis, learning and memory. Here, we examined the effects of developmental TNF de...

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Bibliographic Details
Main Authors: Leda Mygind, Marianne Skov-Skov Bergh, Vivien Tejsi, Ramanan Vaitheeswaran, Kate L. Lambertsen, Bente Finsen, Athanasios Metaxas
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cells
Subjects:
TNF
LPS
inflammation
sickness behavior
aging
cognition
Online Access:https://www.mdpi.com/2073-4409/10/3/608

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