Population Pharmacokinetic, Pharmacogenetic, and Pharmacodynamic Analysis of Cyclophosphamide in Ethiopian Breast Cancer Patients

Population Pharmacokinetic, Pharmacogenetic, and Pharmacodynamic Analysis of Cyclophosphamide in Ethiopian Breast Cancer Patients

Cyclophosphamide (CPA) containing chemotherapy regimen is the standard of care for breast cancer treatment in sub-Saharan Africa. Wide inter-individual variations in pharmacokinetics (PK) of cyclophosphamide (CPA) influence the efficacy and toxicity of CPA containing chemotherapy. Data on the pharma...

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Bibliographic Details
Main Authors: Jemal Hussien Ahmed, Eyasu Makonnen, Ronald Kuteesa Bisaso, Jackson Kijumba Mukonzo, Alan Fotoohi, Abraham Aseffa, Rawleigh Howe, Moustapha Hassan, Eleni Aklillu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Pharmacology
Subjects:
cyclophosphamide
pharmacokinetics
CYP3A5
CYP2C9
body surface area
pharmacodynamics
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00406/full

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