Circ0007042 alleviates intervertebral disc degeneration by adsorbing miR-369 to upregulate BMP2 and activate the PI3K/AKt pathway

Circ0007042 alleviates intervertebral disc degeneration by adsorbing miR-369 to upregulate BMP2 and activate the PI3K/AKt pathway

Abstract Background To identify regulatory ncRNA molecules that can cause differential expression of CDH2 in intervertebral disc degeneration (IDD) and explore whether there are other ways to affect the progression of IDD. Methods A primary culture of human nucleus pulposus (NP) cells was establishe...

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Bibliographic Details
Main Authors: Zhenyu Wang, Yuguang Zhao, Yi Liu, Zhigang Qu, Xinming Zhuang, Qingxu Song, Haoyu Li, Jiali Leng
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Arthritis Research & Therapy
Subjects:
Intervertebral disc degeneration
circ_7042
miR-369-3p
CDH2
BMP2
Online Access:https://doi.org/10.1186/s13075-022-02895-7

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