Human endogenous retroviruses and the inflammatory response: A vicious circle associated with health and illness

Human endogenous retroviruses and the inflammatory response: A vicious circle associated with health and illness

Human Endogenous Retroviruses (HERVs) are derived from ancient exogenous retroviral infections that have infected our ancestors’ germline cells, underwent endogenization process, and were passed throughout the generations by retrotransposition and hereditary transmission. HERVs comprise 8% of the hu...

Full description

Bibliographic Details
Main Authors:	Sara Coelho Rangel, Michelly Damasceno da Silva, Amanda Lopes da Silva, Juliana de Melo Batista dos Santos, Lucas Melo Neves, Ana Pedrosa, Fernanda Monteiro Rodrigues, Caio dos Santos Trettel, Guilherme Eustáquio Furtado, Marcelo Paes de Barros, André Luis Lacerda Bachi, Camila Malta Romano, Luiz Henrique Da Silva Nali
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-11-01
Series:	Frontiers in Immunology
Subjects:	human endogenous retrovirus (HERVs) inflammation physiology autoimmune diseases aging related diseases HERV-W
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1057791/full

Similar Items

Human Endogenous Retrovirus K in Cancer: A Potential Biomarker and Immunotherapeutic Target
by: Gislaine Curty, et al.
Published: (2020-07-01)

Human Endogenous Retroviruses Long Terminal Repeat Methylation, Transcription, and Protein Expression in Human Colon Cancer
by: Maria Dolci, et al.
Published: (2020-10-01)

HERV-K(HML7) Integrations in the Human Genome: Comprehensive Characterization and Comparative Analysis in Non-Human Primates
by: Nicole Grandi, et al.
Published: (2021-05-01)

HERV-K Gag RNA and Protein Levels Are Elevated in Malignant Regions of the Prostate in Males with Prostate Cancer
by: Simin D. Rezaei, et al.
Published: (2021-03-01)

The Roles of Human Endogenous Retroviruses (HERVs) in Inflammation
by: Eun-Ji Ko, et al.
Published: (2021-12-01)

Quantitative analysis of human endogenous retrovirus-K transcripts in postmortem premotor cortex fails to confirm elevated expression of HERV-K RNA in amyotrophic lateral sclerosis
by: Jeremy A. Garson, et al.
Published: (2019-03-01)

Variation in proviral content among human genomes mediated by LTR recombination
by: Jainy Thomas, et al.
Published: (2018-12-01)

Comprehensive Analysis of HERV Transcriptome in HIV+ Cells: Absence of HML2 Activation and General Downregulation of Individual HERV Loci
by: Nicole Grandi, et al.
Published: (2020-04-01)

The interaction of human immunodeficiency virus-1 and human endogenous retroviruses in patients (primary cell cultures) and cell line models
by: Federica Mantovani, et al.
Published: (2023-12-01)

Expression of Envelope Protein Encoded by Endogenous Retrovirus K102 in Rheumatoid Arthritis Neutrophils
by: Amanda Laine, et al.
Published: (2023-05-01)

Human Endogenous Retroviruses Are Ancient Acquired Elements Still Shaping Innate Immune Responses
by: Nicole Grandi, et al.
Published: (2018-09-01)

Association of endogenous retroviruses and long terminal repeats with human disorders
by: Iyoko eKatoh, et al.
Published: (2013-09-01)

A human endogenous retrovirus encoded protease potentially cleaves numerous cellular proteins
by: Giuseppe Rigogliuso, et al.
Published: (2019-08-01)

Human endogenous retroviruses and cancer
by: María Gonzalez-Cao, et al.
Published: (2016-12-01)

The Decrease in Human Endogenous Retrovirus-H Activity Runs in Parallel with Improvement in ADHD Symptoms in Patients Undergoing Methylphenidate Therapy
by: Cipriani Chiara, et al.
Published: (2018-10-01)

Human Endogenous Retroviruses and Their Putative Role in the Development of Autoimmune Disorders Such as Multiple Sclerosis
by: Victoria Gröger, et al.
Published: (2018-02-01)

CMV-Promoter Driven Codon-Optimized Expression Alters the Assembly Type and Morphology of a Reconstituted HERV-K(HML-2)
by: Oliver Hohn, et al.
Published: (2014-11-01)

Human endogenous retroviruses as pathogenic factors in the development of schizophrenia
by: Gregor eHasler, et al.
Published: (2016-01-01)

Human Endogenous Retrovirus as Therapeutic Targets in Neurologic Disease
by: Karen Giménez-Orenga, et al.
Published: (2021-05-01)

Retrovirus insertion site analysis of LGL leukemia patient genomes
by: Weiling Li, et al.
Published: (2019-06-01)

Human endogenous retrovirus np9 gene is over expressed in chronic lymphocytic leukemia patients
by: Sabrina Fischer, et al.
Published: (2014-01-01)

Locus specific endogenous retroviral expression associated with Alzheimer’s disease
by: Tyson Dawson, et al.
Published: (2023-07-01)

Confounding factors in profiling of locus-specific human endogenous retrovirus (HERV) transcript signatures in primary T cells using multi-study-derived datasets
by: Martin V. Hamann, et al.
Published: (2023-04-01)

Human Endogenous Retrovirus-K (HML-2)-Related Genetic Variation: Human Genome Diversity and Disease
by: Wonseok Shin, et al.
Published: (2023-11-01)

Viruses and Endogenous Retroviruses as Roots for Neuroinflammation and Neurodegenerative Diseases
by: Christine Römer
Published: (2021-03-01)

WebHERV: A Web Server for the Computational Investigation of Gene Expression Associated With Endogenous Retrovirus-Like Sequences
by: Konstantin Kruse, et al.
Published: (2018-11-01)

Beyond pathogens: the intriguing genetic legacy of endogenous retroviruses in host physiology
by: Amanda Lopes da Silva, et al.
Published: (2024-04-01)

Preliminary Evidence of the Differential Expression of Human Endogenous Retroviruses in Kawasaki Disease and SARS-CoV-2-Associated Multisystem Inflammatory Syndrome in Children
by: Emanuela Balestrieri, et al.
Published: (2023-10-01)

Human Endogenous Retroviruses Are Preferentially Expressed in Mononuclear Cells From Cord Blood Than From Maternal Blood and in the Fetal Part of Placenta
by: Massimiliano Bergallo, et al.
Published: (2020-05-01)

Vitamin D, Epstein-Barr virus, and endogenous retroviruses in multiple sclerosis - facts and hypotheses
by: Christine Brütting, et al.
Published: (2021-03-01)

An assessment of bioinformatics tools for the detection of human endogenous retroviral insertions in short-read genome sequencing data
by: Harry Bowles, et al.
Published: (2023-02-01)

HERV-K(HML-2), the best preserved family of HERVs: endogenisation, expression and implications in health and disease
by: Oliver eHohn, et al.
Published: (2013-09-01)

Technical considerations in detection of HERV-K in amyotrophic lateral sclerosis: selection of controls and the perils of qPCR
by: Marta Garcia-Montojo, et al.
Published: (2019-07-01)

HERV Envelope Proteins: Physiological Role and Pathogenic Potential in Cancer and Autoimmunity
by: Nicole Grandi, et al.
Published: (2018-03-01)

Activation of LTRs from Different Human Endogenous Retrovirus (HERV) Families by the HTLV-1 Tax Protein and T-Cell Activators
by: Sebastien Landry, et al.
Published: (2011-11-01)

Characterising a human endogenous retrovirus(HERV)-derived tumour-associated antigen: enriched RNA-Seq analysis of HERV-K(HML-2) in mantle cell lymphoma cell lines
by: Witold Tatkiewicz, et al.
Published: (2020-02-01)

Immunogenicity of the Envelope Surface Unit of Human Endogenous Retrovirus K18 in Mice
by: Victoria Ilse, et al.
Published: (2022-07-01)

Ribosomal profiling of human endogenous retroviruses in healthy tissues
by: Nicholas Dopkins, et al.
Published: (2024-01-01)

Epigenetic Control of Human Endogenous Retrovirus Expression: Focus on Regulation of Long-Terminal Repeats (LTRs)
by: Tara P. Hurst, et al.
Published: (2017-05-01)

Transcriptome Analysis of Human Endogenous Retroviruses at Locus-Specific Resolution in Non-Small Cell Lung Cancer
by: Alessandro La Ferlita, et al.
Published: (2022-09-01)