Skin Anti-Aging Efficacy of a <i>Lactobacillus plantarum</i> GT-17F Fermented <i>Dendrobium officinale</i> Ingredient: A Randomized, Double-Blind, Placebo-Controlled Clinical Study
We previously found that fermented extract of <i>Dendrobium officinale</i> using <i>Lactobacillus plantarum</i> GT-17F has a stronger antioxidant effect, especially in free radical scavenging. The result provided a basis for further studies to evaluate the effectiveness of fe...
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MDPI AG
2024-02-01
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| Series: | Cosmetics |
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| Online Access: | https://www.mdpi.com/2079-9284/11/1/26 |
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| author | Weicheng Fei Masafumi Noda Narandalai Danshiitsoodol Masanori Sugiyama |
| author_facet | Weicheng Fei Masafumi Noda Narandalai Danshiitsoodol Masanori Sugiyama |
| author_sort | Weicheng Fei |
| collection | DOAJ |
| description | We previously found that fermented extract of <i>Dendrobium officinale</i> using <i>Lactobacillus plantarum</i> GT-17F has a stronger antioxidant effect, especially in free radical scavenging. The result provided a basis for further studies to evaluate the effectiveness of fermented <i>D. officinale</i> in preventing UV-mediated damage and photoaging in humans. Therefore, in this study, we aimed to assess the anti-aging efficacy of <i>D. officinale</i> fermented with GT-17F strain in a clinical trial, which was conducted as a double-blind, placebo-controlled, randomized parallel-group comparative study with 99 volunteers with visible wrinkles. During the study, subjects were instructed to apply one pump of each essence, which contains fermented, unfermented, or no <i>D. officinale</i> extract, evenly to their face, both in the morning and evening, following their cleansing routine. At 28 days post-treatment, compared to baseline, subjects in the fermented extract group demonstrated significant improvements in stratum corneum water content, skin elasticity, skin glossiness, wrinkle area and ratio, erythema area, and erythema area ratio. In contrast, the unfermented extract group showed a significant difference only in improving erythema index levels in the skin. This comprehensive study has rigorously investigated the anti-aging effects of <i>D. officinale</i> and its fermented version on human skin, highlighting a notable contribution to dermatological research. |
| first_indexed | 2024-03-07T22:36:44Z |
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| institution | Directory Open Access Journal |
| issn | 2079-9284 |
| language | English |
| last_indexed | 2024-03-07T22:36:44Z |
| publishDate | 2024-02-01 |
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| series | Cosmetics |
| spelling | doaj.art-a8d5b6ae2cdd490d87d24da51d18ed8f2024-02-23T15:13:02ZengMDPI AGCosmetics2079-92842024-02-011112610.3390/cosmetics11010026Skin Anti-Aging Efficacy of a <i>Lactobacillus plantarum</i> GT-17F Fermented <i>Dendrobium officinale</i> Ingredient: A Randomized, Double-Blind, Placebo-Controlled Clinical StudyWeicheng Fei0Masafumi Noda1Narandalai Danshiitsoodol2Masanori Sugiyama3Department of Probiotic Science for Preventive Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, JapanDepartment of Probiotic Science for Preventive Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, JapanDepartment of Probiotic Science for Preventive Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, JapanDepartment of Probiotic Science for Preventive Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8551, JapanWe previously found that fermented extract of <i>Dendrobium officinale</i> using <i>Lactobacillus plantarum</i> GT-17F has a stronger antioxidant effect, especially in free radical scavenging. The result provided a basis for further studies to evaluate the effectiveness of fermented <i>D. officinale</i> in preventing UV-mediated damage and photoaging in humans. Therefore, in this study, we aimed to assess the anti-aging efficacy of <i>D. officinale</i> fermented with GT-17F strain in a clinical trial, which was conducted as a double-blind, placebo-controlled, randomized parallel-group comparative study with 99 volunteers with visible wrinkles. During the study, subjects were instructed to apply one pump of each essence, which contains fermented, unfermented, or no <i>D. officinale</i> extract, evenly to their face, both in the morning and evening, following their cleansing routine. At 28 days post-treatment, compared to baseline, subjects in the fermented extract group demonstrated significant improvements in stratum corneum water content, skin elasticity, skin glossiness, wrinkle area and ratio, erythema area, and erythema area ratio. In contrast, the unfermented extract group showed a significant difference only in improving erythema index levels in the skin. This comprehensive study has rigorously investigated the anti-aging effects of <i>D. officinale</i> and its fermented version on human skin, highlighting a notable contribution to dermatological research.https://www.mdpi.com/2079-9284/11/1/26lactic acid bacteria<i>Lactobacillus plantarum</i>medicinal herbs<i>Dendrobium officinale</i>skin anti-agingclinical study |
| spellingShingle | Weicheng Fei Masafumi Noda Narandalai Danshiitsoodol Masanori Sugiyama Skin Anti-Aging Efficacy of a <i>Lactobacillus plantarum</i> GT-17F Fermented <i>Dendrobium officinale</i> Ingredient: A Randomized, Double-Blind, Placebo-Controlled Clinical Study Cosmetics lactic acid bacteria <i>Lactobacillus plantarum</i> medicinal herbs <i>Dendrobium officinale</i> skin anti-aging clinical study |
| title | Skin Anti-Aging Efficacy of a <i>Lactobacillus plantarum</i> GT-17F Fermented <i>Dendrobium officinale</i> Ingredient: A Randomized, Double-Blind, Placebo-Controlled Clinical Study |
| title_full | Skin Anti-Aging Efficacy of a <i>Lactobacillus plantarum</i> GT-17F Fermented <i>Dendrobium officinale</i> Ingredient: A Randomized, Double-Blind, Placebo-Controlled Clinical Study |
| title_fullStr | Skin Anti-Aging Efficacy of a <i>Lactobacillus plantarum</i> GT-17F Fermented <i>Dendrobium officinale</i> Ingredient: A Randomized, Double-Blind, Placebo-Controlled Clinical Study |
| title_full_unstemmed | Skin Anti-Aging Efficacy of a <i>Lactobacillus plantarum</i> GT-17F Fermented <i>Dendrobium officinale</i> Ingredient: A Randomized, Double-Blind, Placebo-Controlled Clinical Study |
| title_short | Skin Anti-Aging Efficacy of a <i>Lactobacillus plantarum</i> GT-17F Fermented <i>Dendrobium officinale</i> Ingredient: A Randomized, Double-Blind, Placebo-Controlled Clinical Study |
| title_sort | skin anti aging efficacy of a i lactobacillus plantarum i gt 17f fermented i dendrobium officinale i ingredient a randomized double blind placebo controlled clinical study |
| topic | lactic acid bacteria <i>Lactobacillus plantarum</i> medicinal herbs <i>Dendrobium officinale</i> skin anti-aging clinical study |
| url | https://www.mdpi.com/2079-9284/11/1/26 |
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