Topoisomerase 2β and DNA topology during B cell development
Topoisomerase 2β (TOP2B) introduces transient double strand breaks in the DNA helix to remove supercoiling structures and unwind entangled DNA strains. Advances in genomic technologies have enabled the discovery of novel functions for TOP2B in processes such as releasing of the paused RNA polymerase...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.982870/full |
| _version_ | 1811321553926750208 |
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| author | Olivier Papapietro Olivier Papapietro Sergey Nejentsev Sergey Nejentsev Sergey Nejentsev |
| author_facet | Olivier Papapietro Olivier Papapietro Sergey Nejentsev Sergey Nejentsev Sergey Nejentsev |
| author_sort | Olivier Papapietro |
| collection | DOAJ |
| description | Topoisomerase 2β (TOP2B) introduces transient double strand breaks in the DNA helix to remove supercoiling structures and unwind entangled DNA strains. Advances in genomic technologies have enabled the discovery of novel functions for TOP2B in processes such as releasing of the paused RNA polymerase II and maintaining the genome organization through DNA loop domains. Thus, TOP2B can regulate transcription directly by acting on transcription elongation and indirectly by controlling interactions between enhancer and promoter regions through genome folding. The identification of TOP2B mutations in humans unexpectedly revealed a unique role of TOP2B in B-cell progenitors. Here we discuss the functions of TOP2B and the mechanisms leading to the B-cell development defect in patients with TOP2B deficiency. |
| first_indexed | 2024-04-13T13:20:01Z |
| format | Article |
| id | doaj.art-a8d6dfa289d14a2a9d4866131d3a5bd3 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T13:20:01Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-a8d6dfa289d14a2a9d4866131d3a5bd32022-12-22T02:45:21ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-08-011310.3389/fimmu.2022.982870982870Topoisomerase 2β and DNA topology during B cell developmentOlivier Papapietro0Olivier Papapietro1Sergey Nejentsev2Sergey Nejentsev3Sergey Nejentsev4Molecular Cell Biology and Immunology, Amsterdam University Medical Centers (UMC), Vrije Universiteit Amsterdam, Amsterdam, NetherlandsAmsterdam Infection and Immunity, Infectious Diseases, Amsterdam, NetherlandsMolecular Cell Biology and Immunology, Amsterdam University Medical Centers (UMC), Vrije Universiteit Amsterdam, Amsterdam, NetherlandsAmsterdam Infection and Immunity, Infectious Diseases, Amsterdam, NetherlandsDepartment of Medicine, University of Cambridge, Cambridge, United KingdomTopoisomerase 2β (TOP2B) introduces transient double strand breaks in the DNA helix to remove supercoiling structures and unwind entangled DNA strains. Advances in genomic technologies have enabled the discovery of novel functions for TOP2B in processes such as releasing of the paused RNA polymerase II and maintaining the genome organization through DNA loop domains. Thus, TOP2B can regulate transcription directly by acting on transcription elongation and indirectly by controlling interactions between enhancer and promoter regions through genome folding. The identification of TOP2B mutations in humans unexpectedly revealed a unique role of TOP2B in B-cell progenitors. Here we discuss the functions of TOP2B and the mechanisms leading to the B-cell development defect in patients with TOP2B deficiency.https://www.frontiersin.org/articles/10.3389/fimmu.2022.982870/fulltopoisomeraseB celltranscriptionimmunodeficiencygenome organization |
| spellingShingle | Olivier Papapietro Olivier Papapietro Sergey Nejentsev Sergey Nejentsev Sergey Nejentsev Topoisomerase 2β and DNA topology during B cell development Frontiers in Immunology topoisomerase B cell transcription immunodeficiency genome organization |
| title | Topoisomerase 2β and DNA topology during B cell development |
| title_full | Topoisomerase 2β and DNA topology during B cell development |
| title_fullStr | Topoisomerase 2β and DNA topology during B cell development |
| title_full_unstemmed | Topoisomerase 2β and DNA topology during B cell development |
| title_short | Topoisomerase 2β and DNA topology during B cell development |
| title_sort | topoisomerase 2β and dna topology during b cell development |
| topic | topoisomerase B cell transcription immunodeficiency genome organization |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.982870/full |
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