Topoisomerase 2β and DNA topology during B cell development

Topoisomerase 2β and DNA topology during B cell development

Topoisomerase 2β (TOP2B) introduces transient double strand breaks in the DNA helix to remove supercoiling structures and unwind entangled DNA strains. Advances in genomic technologies have enabled the discovery of novel functions for TOP2B in processes such as releasing of the paused RNA polymerase...

Full description

Bibliographic Details
Main Authors:	Olivier Papapietro, Sergey Nejentsev
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-08-01
Series:	Frontiers in Immunology
Subjects:	topoisomerase B cell transcription immunodeficiency genome organization
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.982870/full

Similar Items

Women’s contribution in understanding how topoisomerases, supercoiling, and transcription control genome organization
by: Laura Martin, et al.
Published: (2023-03-01)

Activated PI3 Kinase Delta Syndrome: From Genetics to Therapy
by: David Michalovich, et al.
Published: (2018-02-01)

The Roles of DNA Topoisomerase IIβ in Transcription
by: Ram Madabhushi
Published: (2018-06-01)

DNA Double Strand Breaks and Chromosomal Translocations Induced by DNA Topoisomerase II
by: Fernando Gómez-Herreros, et al.
Published: (2019-12-01)

DNA topoisomerases as molecular targets for anticancer drugs
by: Kamila Buzun, et al.
Published: (2020-01-01)

Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase I and topoisomerase II
by: Huanli Xu, et al.
Published: (2016-11-01)

Plasmodium Topoisomerase VIB and Spo11 Constitute Functional Type IIB Topoisomerase in Malaria Parasite: Its Possible Role in Mitochondrial DNA Segregation
by: Priyanka Singh, et al.
Published: (2023-06-01)

DNA-Topology Simplification by Topoisomerases
by: Andreas Hanke, et al.
Published: (2021-06-01)

Evodiamine Stabilizes Topoisomerase I-DNA Cleavable Complex to Inhibit Topoisomerase I Activity
by: Jau-Lang Hwang, et al.
Published: (2009-03-01)

Recurrent Translocations in Topoisomerase Inhibitor-Related Leukemia Are Determined by the Features of DNA Breaks Rather Than by the Proximity of the Translocating Genes
by: Nikolai A. Lomov, et al.
Published: (2022-08-01)

Actions of a Novel Bacterial Topoisomerase Inhibitor against <i>Neisseria gonorrhoeae</i> Gyrase and Topoisomerase IV: Enhancement of Double-Stranded DNA Breaks
by: Soziema E. Dauda, et al.
Published: (2023-07-01)

Topoisomerase I in Human Disease Pathogenesis and Treatments
by: Min Li, et al.
Published: (2016-06-01)

Mitochondrial topoisomerase 1 inhibition induces topological DNA damage and T cell dysfunction in patients with chronic viral infection
by: Xindi Dang, et al.
Published: (2022-11-01)

What’s on the Other Side of the Gate: A Structural Perspective on DNA Gate Opening of Type IA and IIA DNA Topoisomerases
by: Vita Vidmar, et al.
Published: (2023-02-01)

Archaea: A Gold Mine for Topoisomerase Diversity
by: Florence Garnier, et al.
Published: (2021-05-01)

Suppressing proteasome mediated processing of topoisomerase II DNA-protein complexes preserves genome integrity
by: Nicholas Sciascia, et al.
Published: (2020-02-01)

Neolignans from Licaria chrysophylla and Licaria aurea with DNA topoisomerase II-α inhibitory activity
by: Amanda de Melo Bezerra, et al.
Published: (2012-01-01)

Dimethylmyricacene: An In Vitro and In Silico Study of a Semisynthetic Non-Camptothecin Derivative Compound, Targeting Human DNA Topoisomerase 1B
by: Alessio Ottaviani, et al.
Published: (2022-11-01)

Novel PLCG2 Mutation in a Patient With APLAID and Cutis Laxa
by: João Farela Neves, et al.
Published: (2018-12-01)

Phosphorylation of the human topoisomerase II protein
by: Fry, A, et al.
Published: (1992)

Mechanical determinants of chromatin topology and gene expression
by: Rajiv Kumar Jha, et al.
Published: (2022-12-01)

Transcription-associated topoisomerase 2α (TOP2A) activity is a major effector of cytotoxicity induced by G-quadruplex ligands
by: Madeleine Bossaert, et al.
Published: (2021-06-01)

Topoisomerase I prevents transcription-replication conflicts at transcription termination sites
by: Yaqun Liu, et al.
Published: (2021-01-01)

Physiologic and Transcriptomic Effects Triggered by Overexpression of Wild Type and Mutant DNA Topoisomerase I in <i>Streptococcus pneumoniae</i>
by: Miriam García-López, et al.
Published: (2023-10-01)

SUMO: A Swiss Army Knife for Eukaryotic Topoisomerases
by: Yilun Sun, et al.
Published: (2022-04-01)

Developments in Non-Intercalating Bacterial Topoisomerase Inhibitors: Allosteric and ATPase Inhibitors of DNA Gyrase and Topoisomerase IV
by: Scott Grossman, et al.
Published: (2023-02-01)

Effect of etoposide on grass pea DNA topoisomerase II: an in silico, in vivo, and in vitro assessments
by: Aveek Samanta, et al.
Published: (2019-12-01)

BRCA1-BARD1 regulates transcription through modulating topoisomerase IIβ
by: Heeyoun Bunch, et al.
Published: (2021-10-01)

Variation of Structure and Cellular Functions of Type IA Topoisomerases across the Tree of Life
by: Kemin Tan, et al.
Published: (2024-03-01)

Phaeophytins from Thyrsacanthus ramosissimus Moric. with inhibitory activity on human dna topoisomerase II-α
by: Analúcia Guedes Silveira Cabral, et al.
Published: (2012-01-01)

Prognostic Significance of DNA Topoisomerase II Alpha (TOP2A) in Cholangiocarcinoma
by: Khaa Hoo Ong, et al.
Published: (2023-04-01)

Inhibition of Topoisomerases by Metal Thiosemicarbazone Complexes
by: Xiaohua Jiang, et al.
Published: (2023-07-01)

Targeting DNA Topoisomerase II in Antifungal Chemotherapy
by: Kavya Kondaka, et al.
Published: (2022-11-01)

Natural Compounds as Therapeutic Agents: The Case of Human Topoisomerase IB
by: Alessio Ottaviani, et al.
Published: (2021-04-01)

A Short History of Topoisomerases at Actelion Pharmaceuticals
by: Cornelia Zumbrunn
Published: (2022-08-01)

PHARMACOLOGIC TOPOISOMERASE-I INHIBITION CAUSES DNA DAMAGE AND MORTALITY IN ACTIVATED CD4+ T CELLS
by: Mia Stanić, et al.
Published: (2018-12-01)

From Antarctica to cancer research: a novel human DNA topoisomerase 1B inhibitor from Antarctic sponge Dendrilla antarctica
by: Alessio Ottaviani, et al.
Published: (2022-12-01)

Cytotoxic and DNA-topoisomerase effects of lapachol amine derivatives and interactions with DNA
by: A. Esteves-Souza, et al.
Published: (2007-10-01)

Gel-Free Tools for Quick and Simple Screening of Anti-Topoisomerase 1 Compounds
by: Josephine Geertsen Keller, et al.
Published: (2023-04-01)

Synthesis, DNA Binding and Topoisomerase I Inhibition Activity of Thiazacridine and Imidazacridine Derivatives
by: Elizabeth Almeida Lafayette, et al.
Published: (2013-12-01)