Analysis of the Clinical and Histopathological Patterns of 100 Consecutive Cases of Primary Cutaneous Melanoma and Correlation with Staging
Background This study analyzed 100 consecutive patients with primary cutaneous melanoma over the course of 13 years to determine whether epidemiological differences correspond to different stages of the disease. We also investigated whether epidemiological characteristics affected the survival rate...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Thieme Medical Publishers, Inc.
2015-11-01
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| Series: | Archives of Plastic Surgery |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.5999/aps.2015.42.6.746 |
| _version_ | 1828353626940112896 |
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| author | Kyung Wook Nam Yong Chan Bae Seong Hwan Bae Kyung Ho Song Hoon Soo Kim Young Jin Choi |
| author_facet | Kyung Wook Nam Yong Chan Bae Seong Hwan Bae Kyung Ho Song Hoon Soo Kim Young Jin Choi |
| author_sort | Kyung Wook Nam |
| collection | DOAJ |
| description | Background This study analyzed 100 consecutive patients with primary cutaneous melanoma over the course of 13 years to determine whether epidemiological differences correspond to different stages of the disease. We also investigated whether epidemiological characteristics affected the survival rate. Our results were compared with those of selected descriptive studies of melanoma in other East Asian populations, in order to determine whether cutaneous melanoma patterns are similar in East Asian populations.
Methods The patients' medical records were reviewed retrospectively, and we analyzed the relationship of epidemiological characteristics to staging and survival rate. Additionally, papers from Hong Kong and Japan describing these phenomena in East Asian populations were subjected to a statistical comparison.
Results The ratio of males to females was 1:1.8, and the foot was the most frequent tumor site (49%). Acral lentiginous melanoma occurred most frequently (55%). Nodular melanoma was associated with a higher stage. Stage III-IV tumors with Clark levels of IV-V were significantly associated with a low survival rate. A statistical analysis of comparable papers reported in Hong Kong and Japan showed similar results with regard to age, tumor location, and histopathological subtypes.
Conclusions This study provides the first full epidemiological description of 100 consecutive cases of primary cutaneous melanoma in Korea, with results similar to those observed in other East Asian populations. Corresponding to previous findings, nodular melanoma tended to occur at a higher stage than other types, and tumors with high Clark levels and high stages showed a lower survival rate. |
| first_indexed | 2024-04-14T02:12:24Z |
| format | Article |
| id | doaj.art-a8d70fc83c2d4ac3842c966ee6505210 |
| institution | Directory Open Access Journal |
| issn | 2234-6163 2234-6171 |
| language | English |
| last_indexed | 2024-04-14T02:12:24Z |
| publishDate | 2015-11-01 |
| publisher | Thieme Medical Publishers, Inc. |
| record_format | Article |
| series | Archives of Plastic Surgery |
| spelling | doaj.art-a8d70fc83c2d4ac3842c966ee65052102022-12-22T02:18:25ZengThieme Medical Publishers, Inc.Archives of Plastic Surgery2234-61632234-61712015-11-01420674675210.5999/aps.2015.42.6.746603Analysis of the Clinical and Histopathological Patterns of 100 Consecutive Cases of Primary Cutaneous Melanoma and Correlation with StagingKyung Wook Nam0Yong Chan Bae1Seong Hwan Bae2Kyung Ho Song3Hoon Soo Kim4Young Jin Choi5Department of Plastic and Reconstructive Surgery, Pusan National University School of Medicine, Buasn, KoreaDepartment of Plastic and Reconstructive Surgery, Pusan National University School of Medicine, Buasn, KoreaDepartment of Plastic and Reconstructive Surgery, Pusan National University School of Medicine, Buasn, KoreaDepartment of Plastic and Reconstructive Surgery, Pusan National University School of Medicine, Buasn, KoreaDepartment of Dermatology, Pusan National University School of Medicine, Busan, KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, KoreaBackground This study analyzed 100 consecutive patients with primary cutaneous melanoma over the course of 13 years to determine whether epidemiological differences correspond to different stages of the disease. We also investigated whether epidemiological characteristics affected the survival rate. Our results were compared with those of selected descriptive studies of melanoma in other East Asian populations, in order to determine whether cutaneous melanoma patterns are similar in East Asian populations. Methods The patients' medical records were reviewed retrospectively, and we analyzed the relationship of epidemiological characteristics to staging and survival rate. Additionally, papers from Hong Kong and Japan describing these phenomena in East Asian populations were subjected to a statistical comparison. Results The ratio of males to females was 1:1.8, and the foot was the most frequent tumor site (49%). Acral lentiginous melanoma occurred most frequently (55%). Nodular melanoma was associated with a higher stage. Stage III-IV tumors with Clark levels of IV-V were significantly associated with a low survival rate. A statistical analysis of comparable papers reported in Hong Kong and Japan showed similar results with regard to age, tumor location, and histopathological subtypes. Conclusions This study provides the first full epidemiological description of 100 consecutive cases of primary cutaneous melanoma in Korea, with results similar to those observed in other East Asian populations. Corresponding to previous findings, nodular melanoma tended to occur at a higher stage than other types, and tumors with high Clark levels and high stages showed a lower survival rate.http://www.thieme-connect.de/DOI/DOI?10.5999/aps.2015.42.6.746melanomaskin neoplasmsneoplasm staging |
| spellingShingle | Kyung Wook Nam Yong Chan Bae Seong Hwan Bae Kyung Ho Song Hoon Soo Kim Young Jin Choi Analysis of the Clinical and Histopathological Patterns of 100 Consecutive Cases of Primary Cutaneous Melanoma and Correlation with Staging Archives of Plastic Surgery melanoma skin neoplasms neoplasm staging |
| title | Analysis of the Clinical and Histopathological Patterns of 100 Consecutive Cases of Primary Cutaneous Melanoma and Correlation with Staging |
| title_full | Analysis of the Clinical and Histopathological Patterns of 100 Consecutive Cases of Primary Cutaneous Melanoma and Correlation with Staging |
| title_fullStr | Analysis of the Clinical and Histopathological Patterns of 100 Consecutive Cases of Primary Cutaneous Melanoma and Correlation with Staging |
| title_full_unstemmed | Analysis of the Clinical and Histopathological Patterns of 100 Consecutive Cases of Primary Cutaneous Melanoma and Correlation with Staging |
| title_short | Analysis of the Clinical and Histopathological Patterns of 100 Consecutive Cases of Primary Cutaneous Melanoma and Correlation with Staging |
| title_sort | analysis of the clinical and histopathological patterns of 100 consecutive cases of primary cutaneous melanoma and correlation with staging |
| topic | melanoma skin neoplasms neoplasm staging |
| url | http://www.thieme-connect.de/DOI/DOI?10.5999/aps.2015.42.6.746 |
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