Oxysterol 7-α Hydroxylase (CYP7B1) Attenuates Metabolic-Associated Fatty Liver Disease in Mice at Thermoneutrality

Oxysterol 7-α Hydroxylase (CYP7B1) Attenuates Metabolic-Associated Fatty Liver Disease in Mice at Thermoneutrality

Ambient temperature is an important determinant of both the alternative bile acid synthesis pathway controlled by oxysterol 7-α hydroxylase (CYP7B1) and the progression of metabolic-associated fatty liver disease (MAFLD). Here, we investigated whether CYP7B1 is involved in the etiology of MAFLD unde...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Ioannis Evangelakos, Dorothee Schwinge, Anna Worthmann, Clara John, Niklas Roeder, Paul Pertzborn, Janina Behrens, Christoph Schramm, Ludger Scheja, Joerg Heeren
Format: Artikel
Sprache:English
Veröffentlicht: MDPI AG 2021-10-01
Schriftenreihe:Cells
Schlagworte:
bile acids
hydroxycholesterol
oxysterol
Cyp7b1
non-alcoholic fatty liver disease
T cells
Online Zugang:https://www.mdpi.com/2073-4409/10/10/2656

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