Update on Genetic Susceptibility and Pathogenesis in Juvenile Idiopathic Arthritis
Juvenile idiopathic arthritis (JIA) is a multifactorial disease with a pathogenesis which remains inexplicable. However, genome-wide association studies brought forward within recent years have discovered several new susceptibility genes, and accumulating evidence supports genetic variability as pla...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Medical Journal
2014-07-01
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| Series: | European Medical Journal Rheumatology |
| Subjects: | |
| Online Access: | http://emjreviews.com/wp-content/uploads/Update-On-Genetic-Susceptibility-And-Pathogenesis-In-Juvenile-Idiopathic-Arthritis.pdf |
| Summary: | Juvenile idiopathic arthritis (JIA) is a multifactorial disease with a pathogenesis which remains inexplicable. However, genome-wide association studies brought forward within recent years have discovered several new susceptibility genes, and accumulating evidence supports genetic variability as playing a key role in JIA development. This review summarises the present knowledge of human leukocyte antigen (HLA) and non-HLA polymorphisms conferring disease susceptibility, and discusses the areas in JIA genetics, which are still to be investigated in order to apply JIA genetics in a clinical setting. |
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| ISSN: | 2056-6395 |