Update on Genetic Susceptibility and Pathogenesis in Juvenile Idiopathic Arthritis
Juvenile idiopathic arthritis (JIA) is a multifactorial disease with a pathogenesis which remains inexplicable. However, genome-wide association studies brought forward within recent years have discovered several new susceptibility genes, and accumulating evidence supports genetic variability as pla...
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| Format: | Article |
| Language: | English |
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European Medical Journal
2014-07-01
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| Series: | European Medical Journal Rheumatology |
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| Online Access: | http://emjreviews.com/wp-content/uploads/Update-On-Genetic-Susceptibility-And-Pathogenesis-In-Juvenile-Idiopathic-Arthritis.pdf |
| _version_ | 1819001855855820800 |
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| author | Morten Herlin Michael B. Petersen Troels Herlin |
| author_facet | Morten Herlin Michael B. Petersen Troels Herlin |
| author_sort | Morten Herlin |
| collection | DOAJ |
| description | Juvenile idiopathic arthritis (JIA) is a multifactorial disease with a pathogenesis which remains inexplicable. However, genome-wide association studies brought forward within recent years have discovered several new susceptibility genes, and accumulating evidence supports genetic variability as playing a key role in JIA development. This review summarises the present knowledge of human leukocyte antigen (HLA) and non-HLA polymorphisms conferring disease susceptibility, and discusses the areas in JIA genetics, which are still to be investigated in order to apply JIA genetics in a clinical setting. |
| first_indexed | 2024-12-20T22:55:51Z |
| format | Article |
| id | doaj.art-a8d8ce0b7a9d4d9eb2a9bf6fd6b99c81 |
| institution | Directory Open Access Journal |
| issn | 2056-6395 |
| language | English |
| last_indexed | 2024-12-20T22:55:51Z |
| publishDate | 2014-07-01 |
| publisher | European Medical Journal |
| record_format | Article |
| series | European Medical Journal Rheumatology |
| spelling | doaj.art-a8d8ce0b7a9d4d9eb2a9bf6fd6b99c812022-12-21T19:24:07ZengEuropean Medical JournalEuropean Medical Journal Rheumatology2056-63952014-07-01117383Update on Genetic Susceptibility and Pathogenesis in Juvenile Idiopathic ArthritisMorten Herlin0Michael B. Petersen1Troels Herlin2Department of Clinical Genetics, Aalborg University Hospital, Aalborg, Denmark. Department of Clinical Medicine, Aalborg University, Aalborg, DenmarkDepartment of Clinical Genetics, Aalborg University Hospital, Aalborg, Denmark. Department of Clinical Medicine, Aalborg University, Aalborg, DenmarkPediatric Rheumatology Clinic, Department of Pediatrics, Aarhus University Hospital, Aarhus, DenmarkJuvenile idiopathic arthritis (JIA) is a multifactorial disease with a pathogenesis which remains inexplicable. However, genome-wide association studies brought forward within recent years have discovered several new susceptibility genes, and accumulating evidence supports genetic variability as playing a key role in JIA development. This review summarises the present knowledge of human leukocyte antigen (HLA) and non-HLA polymorphisms conferring disease susceptibility, and discusses the areas in JIA genetics, which are still to be investigated in order to apply JIA genetics in a clinical setting.http://emjreviews.com/wp-content/uploads/Update-On-Genetic-Susceptibility-And-Pathogenesis-In-Juvenile-Idiopathic-Arthritis.pdfarthritisgenetic predisposition to diseaseGeneticsindividualised medicine.juvenileJuvenile idiopathic arthritis |
| spellingShingle | Morten Herlin Michael B. Petersen Troels Herlin Update on Genetic Susceptibility and Pathogenesis in Juvenile Idiopathic Arthritis European Medical Journal Rheumatology arthritis genetic predisposition to disease Genetics individualised medicine. juvenile Juvenile idiopathic arthritis |
| title | Update on Genetic Susceptibility and Pathogenesis in Juvenile Idiopathic Arthritis |
| title_full | Update on Genetic Susceptibility and Pathogenesis in Juvenile Idiopathic Arthritis |
| title_fullStr | Update on Genetic Susceptibility and Pathogenesis in Juvenile Idiopathic Arthritis |
| title_full_unstemmed | Update on Genetic Susceptibility and Pathogenesis in Juvenile Idiopathic Arthritis |
| title_short | Update on Genetic Susceptibility and Pathogenesis in Juvenile Idiopathic Arthritis |
| title_sort | update on genetic susceptibility and pathogenesis in juvenile idiopathic arthritis |
| topic | arthritis genetic predisposition to disease Genetics individualised medicine. juvenile Juvenile idiopathic arthritis |
| url | http://emjreviews.com/wp-content/uploads/Update-On-Genetic-Susceptibility-And-Pathogenesis-In-Juvenile-Idiopathic-Arthritis.pdf |
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