Is the Complement Protein C1q a Pro- or Anti-tumorigenic Factor? Bioinformatics Analysis Involving Human Carcinomas

Is the Complement Protein C1q a Pro- or Anti-tumorigenic Factor? Bioinformatics Analysis Involving Human Carcinomas

C1q is the first subcomponent of the classical pathway of the complement system and belongs to the C1q/Tumor Necrosis Factor superfamily. C1q can perform a diverse range of immune and non-immune functions in a complement-dependent as well as -independent manner. Being a pattern recognition molecule...

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Bibliographic Details
Main Authors: Alessandro Mangogna, Chiara Agostinis, Deborah Bonazza, Beatrice Belmonte, Paola Zacchi, Gabriella Zito, Andrea Romano, Fabrizio Zanconati, Giuseppe Ricci, Uday Kishore, Roberta Bulla
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
complement
classical pathway
C1q
tumor
microenvironment
prognosis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00865/full

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