Hybrid Deep Modeling of a GS115 (Mut+) <i>Pichia pastoris</i> Culture with State–Space Reduction

Hybrid Deep Modeling of a GS115 (Mut+) <i>Pichia pastoris</i> Culture with State–Space Reduction

Hybrid modeling workflows combining machine learning with mechanistic process descriptions are becoming essential tools for bioprocess digitalization. In this study, a hybrid deep modeling method with state–space reduction was developed and showcased with a <i>P. pastoris</i> GS115 Mut+...

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Bibliographic Details
Main Authors: José Pinto, João R. C. Ramos, Rafael S. Costa, Rui Oliveira
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Fermentation
Subjects:
hybrid modeling
deep learning
ADAM method
<i>Pichia pastoris</i> GS115 Mut+
single-chain antibody fragment (scFv)
bioprocess digitalization
Online Access:https://www.mdpi.com/2311-5637/9/7/643

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