Delay-dependent contributions of medial temporal lobe regions to episodic memory retrieval
The medial temporal lobes play an important role in episodic memory, but over time, hippocampal contributions to retrieval may be diminished. However, it is unclear whether such changes are related to the ability to retrieve contextual information, and whether they are common across all medial tempo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2015-01-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/05025 |
| _version_ | 1818018944258146304 |
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| author | Maureen Ritchey Maria E Montchal Andrew P Yonelinas Charan Ranganath |
| author_facet | Maureen Ritchey Maria E Montchal Andrew P Yonelinas Charan Ranganath |
| author_sort | Maureen Ritchey |
| collection | DOAJ |
| description | The medial temporal lobes play an important role in episodic memory, but over time, hippocampal contributions to retrieval may be diminished. However, it is unclear whether such changes are related to the ability to retrieve contextual information, and whether they are common across all medial temporal regions. Here, we used functional neuroimaging to compare neural responses during immediate and delayed recognition. Results showed that recollection-related activity in the posterior hippocampus declined after a 1-day delay. In contrast, activity was relatively stable in the anterior hippocampus and in neocortical areas. Multi-voxel pattern similarity analyses also revealed that anterior hippocampal patterns contained information about context during item recognition, and after a delay, context coding in this region was related to successful retention of context information. Together, these findings suggest that the anterior and posterior hippocampus have different contributions to memory over time and that neurobiological models of memory must account for these differences. |
| first_indexed | 2024-04-14T07:46:21Z |
| format | Article |
| id | doaj.art-a8dcd37ad2a84e7a93b574166f276217 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-14T07:46:21Z |
| publishDate | 2015-01-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-a8dcd37ad2a84e7a93b574166f2762172022-12-22T02:05:20ZengeLife Sciences Publications LtdeLife2050-084X2015-01-01410.7554/eLife.05025Delay-dependent contributions of medial temporal lobe regions to episodic memory retrievalMaureen Ritchey0https://orcid.org/0000-0002-5957-3642Maria E Montchal1Andrew P Yonelinas2Charan Ranganath3https://orcid.org/0000-0001-5835-6091Center for Neuroscience, University of California, Davis, Davis, United StatesCenter for Neuroscience, University of California, Davis, Davis, United StatesDepartment of Psychology, University of California, Davis, Davis, United StatesCenter for Neuroscience, University of California, Davis, Davis, United States; Department of Psychology, University of California, Davis, Davis, United StatesThe medial temporal lobes play an important role in episodic memory, but over time, hippocampal contributions to retrieval may be diminished. However, it is unclear whether such changes are related to the ability to retrieve contextual information, and whether they are common across all medial temporal regions. Here, we used functional neuroimaging to compare neural responses during immediate and delayed recognition. Results showed that recollection-related activity in the posterior hippocampus declined after a 1-day delay. In contrast, activity was relatively stable in the anterior hippocampus and in neocortical areas. Multi-voxel pattern similarity analyses also revealed that anterior hippocampal patterns contained information about context during item recognition, and after a delay, context coding in this region was related to successful retention of context information. Together, these findings suggest that the anterior and posterior hippocampus have different contributions to memory over time and that neurobiological models of memory must account for these differences.https://elifesciences.org/articles/05025fMRImulti-voxel pattern analysisrepresentational similarity analysisrecognition memoryconsolidation |
| spellingShingle | Maureen Ritchey Maria E Montchal Andrew P Yonelinas Charan Ranganath Delay-dependent contributions of medial temporal lobe regions to episodic memory retrieval eLife fMRI multi-voxel pattern analysis representational similarity analysis recognition memory consolidation |
| title | Delay-dependent contributions of medial temporal lobe regions to episodic memory retrieval |
| title_full | Delay-dependent contributions of medial temporal lobe regions to episodic memory retrieval |
| title_fullStr | Delay-dependent contributions of medial temporal lobe regions to episodic memory retrieval |
| title_full_unstemmed | Delay-dependent contributions of medial temporal lobe regions to episodic memory retrieval |
| title_short | Delay-dependent contributions of medial temporal lobe regions to episodic memory retrieval |
| title_sort | delay dependent contributions of medial temporal lobe regions to episodic memory retrieval |
| topic | fMRI multi-voxel pattern analysis representational similarity analysis recognition memory consolidation |
| url | https://elifesciences.org/articles/05025 |
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