P-40 IS THERE A DISTINCT PHENOTYPE OF NON-ALCOHOLIC FATTY LIVER DISEASE IN LEAN AND OVERWEIGHT PATIENTS?
Introduction and Objectives: Non-alcoholic fatty liver disease (NAFLD) is not an exclusive disease of obese patients. Lean and overweight patients also deal with this disease. This study aimed to analyze if there is any different NAFLD phenotype between lean and overweight patients. Materials and Me...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Annals of Hepatology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268123000467 |
| _version_ | 1797862197072756736 |
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| author | Denise Siqueira Vanni José Tadeu Stefano Sebastião Mauro Bezerra Duarte Patricia Momoyo Yoshiura Zitelli Renato Gama Altikes Karla Toda Oti Mário Guimarães Pessoa Flair José Carrilho Claudia P Oliveira |
| author_facet | Denise Siqueira Vanni José Tadeu Stefano Sebastião Mauro Bezerra Duarte Patricia Momoyo Yoshiura Zitelli Renato Gama Altikes Karla Toda Oti Mário Guimarães Pessoa Flair José Carrilho Claudia P Oliveira |
| author_sort | Denise Siqueira Vanni |
| collection | DOAJ |
| description | Introduction and Objectives: Non-alcoholic fatty liver disease (NAFLD) is not an exclusive disease of obese patients. Lean and overweight patients also deal with this disease. This study aimed to analyze if there is any different NAFLD phenotype between lean and overweight patients. Materials and Methods: This is a cross-sectional study of descriptive characteristics of lean (BMI ≤ 24.9kg/m2) and overweight (BMI 25-29.9kg/m2) patients from a NAFLD outpatient care facility at a Tertiary reference hospital in Sao Paulo, Brazil. The analysis included: gender, age, BMI, Insulin Resistance (IR), Type 2 Diabetes Mellitus (T2DM), Systemic Arterial Hypertension (SAH), Dyslipidemia (DLP), ALT, AST, GGT, ferritin, liver stiffness, CAP, Fibrosis stages and NAS score. Mann-Whitney U test, Welch two-sample t-test and Fischer's exact test were used. Results: A total of 68 (54 overweight; 14 lean) NAFLD patients were analyzed. Female majority in each group (86% lean; 67% overweight). Similar mean age: in lean 63.79yo (CI95% 59.23-68.34yo) and in overweight 63.80yo (CI95%60.91-66.68yo). The mean BMI in lean was 22.77 kg/m2 (CI95% 22.08-23.47 kg/m2) and in overweight was 27.19 kg/m2 (CI95% 26.85-27.54 kg/m2). The majority of the groups had T2DM, DLP and SAH. IR occurred in 26% and 14% of overweight and lean, respectively. In the lean group, 13% didn't have IR or T2DM. ALT, AST, GGT, ferritin, liver stiffness and CAP between groups had no significant statistical difference (p > 0.05). Advanced fibrosis (≥ F3) in 7 (50%) lean and 30 (68%) overweight patients (p= 0.182). NASH (NAS ≥ 4) in 9 (64%) of the lean and 44 (81%) of the overweight (p= 0.222). Conclusions: In this small population study, preliminary results infer that lean and overweight NAFLD patients have similar characteristics. A large-scale study could confirm this data. Perhaps we should consider lean and overweight as one non-obese NAFLD group and eventually compare them with obese counterparts in future studies. |
| first_indexed | 2024-04-09T22:16:26Z |
| format | Article |
| id | doaj.art-a8ddc660e0264ac285f110192e77e2e7 |
| institution | Directory Open Access Journal |
| issn | 1665-2681 |
| language | English |
| last_indexed | 2024-04-09T22:16:26Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of Hepatology |
| spelling | doaj.art-a8ddc660e0264ac285f110192e77e2e72023-03-23T04:34:03ZengElsevierAnnals of Hepatology1665-26812023-03-0128100942P-40 IS THERE A DISTINCT PHENOTYPE OF NON-ALCOHOLIC FATTY LIVER DISEASE IN LEAN AND OVERWEIGHT PATIENTS?Denise Siqueira Vanni0José Tadeu Stefano1Sebastião Mauro Bezerra Duarte2Patricia Momoyo Yoshiura Zitelli3Renato Gama Altikes4Karla Toda Oti5Mário Guimarães Pessoa6Flair José Carrilho7Claudia P Oliveira8Division of Clinical Gastroenterology and Hepatology (Lim-07), Clinics Hospital, Department of Gastroenterology, University of São Paulo School of Medicine, Sao Paulo, BrazilDivision of Clinical Gastroenterology and Hepatology (Lim-07), Clinics Hospital, Department of Gastroenterology, University of São Paulo School of Medicine, Sao Paulo, BrazilDivision of Clinical Gastroenterology and Hepatology (Lim-07), Clinics Hospital, Department of Gastroenterology, University of São Paulo School of Medicine, Sao Paulo, BrazilDivision of Clinical Gastroenterology and Hepatology (Lim-07), Clinics Hospital, Department of Gastroenterology, University of São Paulo School of Medicine, Sao Paulo, BrazilDivision of Clinical Gastroenterology and Hepatology (Lim-07), Clinics Hospital, Department of Gastroenterology, University of São Paulo School of Medicine, Sao Paulo, BrazilDivision of Clinical Gastroenterology and Hepatology (Lim-07), Clinics Hospital, Department of Gastroenterology, University of São Paulo School of Medicine, Sao Paulo, BrazilDivision of Clinical Gastroenterology and Hepatology (Lim-07), Clinics Hospital, Department of Gastroenterology, University of São Paulo School of Medicine, Sao Paulo, BrazilDivision of Clinical Gastroenterology and Hepatology (Lim-07), Clinics Hospital, Department of Gastroenterology, University of São Paulo School of Medicine, Sao Paulo, BrazilDivision of Clinical Gastroenterology and Hepatology (Lim-07), Clinics Hospital, Department of Gastroenterology, University of São Paulo School of Medicine, Sao Paulo, BrazilIntroduction and Objectives: Non-alcoholic fatty liver disease (NAFLD) is not an exclusive disease of obese patients. Lean and overweight patients also deal with this disease. This study aimed to analyze if there is any different NAFLD phenotype between lean and overweight patients. Materials and Methods: This is a cross-sectional study of descriptive characteristics of lean (BMI ≤ 24.9kg/m2) and overweight (BMI 25-29.9kg/m2) patients from a NAFLD outpatient care facility at a Tertiary reference hospital in Sao Paulo, Brazil. The analysis included: gender, age, BMI, Insulin Resistance (IR), Type 2 Diabetes Mellitus (T2DM), Systemic Arterial Hypertension (SAH), Dyslipidemia (DLP), ALT, AST, GGT, ferritin, liver stiffness, CAP, Fibrosis stages and NAS score. Mann-Whitney U test, Welch two-sample t-test and Fischer's exact test were used. Results: A total of 68 (54 overweight; 14 lean) NAFLD patients were analyzed. Female majority in each group (86% lean; 67% overweight). Similar mean age: in lean 63.79yo (CI95% 59.23-68.34yo) and in overweight 63.80yo (CI95%60.91-66.68yo). The mean BMI in lean was 22.77 kg/m2 (CI95% 22.08-23.47 kg/m2) and in overweight was 27.19 kg/m2 (CI95% 26.85-27.54 kg/m2). The majority of the groups had T2DM, DLP and SAH. IR occurred in 26% and 14% of overweight and lean, respectively. In the lean group, 13% didn't have IR or T2DM. ALT, AST, GGT, ferritin, liver stiffness and CAP between groups had no significant statistical difference (p > 0.05). Advanced fibrosis (≥ F3) in 7 (50%) lean and 30 (68%) overweight patients (p= 0.182). NASH (NAS ≥ 4) in 9 (64%) of the lean and 44 (81%) of the overweight (p= 0.222). Conclusions: In this small population study, preliminary results infer that lean and overweight NAFLD patients have similar characteristics. A large-scale study could confirm this data. Perhaps we should consider lean and overweight as one non-obese NAFLD group and eventually compare them with obese counterparts in future studies.http://www.sciencedirect.com/science/article/pii/S1665268123000467 |
| spellingShingle | Denise Siqueira Vanni José Tadeu Stefano Sebastião Mauro Bezerra Duarte Patricia Momoyo Yoshiura Zitelli Renato Gama Altikes Karla Toda Oti Mário Guimarães Pessoa Flair José Carrilho Claudia P Oliveira P-40 IS THERE A DISTINCT PHENOTYPE OF NON-ALCOHOLIC FATTY LIVER DISEASE IN LEAN AND OVERWEIGHT PATIENTS? Annals of Hepatology |
| title | P-40 IS THERE A DISTINCT PHENOTYPE OF NON-ALCOHOLIC FATTY LIVER DISEASE IN LEAN AND OVERWEIGHT PATIENTS? |
| title_full | P-40 IS THERE A DISTINCT PHENOTYPE OF NON-ALCOHOLIC FATTY LIVER DISEASE IN LEAN AND OVERWEIGHT PATIENTS? |
| title_fullStr | P-40 IS THERE A DISTINCT PHENOTYPE OF NON-ALCOHOLIC FATTY LIVER DISEASE IN LEAN AND OVERWEIGHT PATIENTS? |
| title_full_unstemmed | P-40 IS THERE A DISTINCT PHENOTYPE OF NON-ALCOHOLIC FATTY LIVER DISEASE IN LEAN AND OVERWEIGHT PATIENTS? |
| title_short | P-40 IS THERE A DISTINCT PHENOTYPE OF NON-ALCOHOLIC FATTY LIVER DISEASE IN LEAN AND OVERWEIGHT PATIENTS? |
| title_sort | p 40 is there a distinct phenotype of non alcoholic fatty liver disease in lean and overweight patients |
| url | http://www.sciencedirect.com/science/article/pii/S1665268123000467 |
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