Discovery of Novel Reductive Elimination Pathway for 10-Hydroxywarfarin

Discovery of Novel Reductive Elimination Pathway for 10-Hydroxywarfarin

Coumadin (R/S-warfarin) anticoagulant therapy is highly efficacious in preventing the formation of blood clots; however, significant inter-individual variations in response risks over or under dosing resulting in adverse bleeding events or ineffective therapy, respectively. Levels of pharmacological...

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Bibliographic Details
Main Authors: Dakota L. Pouncey, Dustyn A. Barnette, Riley W. Sinnott, Sarah J. Phillips, Noah R. Flynn, Howard P. Hendrickson, S. Joshua Swamidass, Grover P. Miller
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Pharmacology
Subjects:
anticoagulation
warfarin
hydroxywarfarin
metabolism
modeling
reduction
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.805133/full

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