Fluorine and chlorine substituted adamantyl-urea as molecular tools for inhibition of human soluble epoxide hydrolase with picomolar efficacy

Fluorine and chlorine substituted adamantyl-urea as molecular tools for inhibition of human soluble epoxide hydrolase with picomolar efficacy

AbstractSeries of 1,3-disubstituted ureas and diadamantyl disubstituted diureas with fluorinated and chlorinated adamantane residues were shown to inhibit human soluble epoxide hydrolase (sEH) with inhibition potency ranging from 40 pM to 9.2 nM. The measured IC50 values for some molecules were belo...

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Bibliographic Details
Main Authors: Vladimir V. Burmistrov, Christophe Morisseau, Dmitry V. Danilov, Boris P. Gladkikh, Vladimir S. D’yachenko, Nikolay A. Zefirov, Olga N. Zefirova, Gennady M. Butov, Bruce D. Hammock
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Soluble epoxide hydrolase inhibitors
adamantane
urea
diurea
chlorine substituted adamantanes
fluorine substituted adamantanes
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2023.2274797

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