Prevalence, risk factors and adverse perinatal outcomes for Chinese women with intrahepatic cholestasis of pregnancy: a large cross-sectional retrospective study
Background Intrahepatic cholestasis of pregnancy (ICP) is the most common pregnancy-related liver disorder and may cause adverse perinatal outcomes. This large cross-sectional retrospective study aimed to evaluate the prevalence and related risk factors of ICP and determine the adverse perinatal out...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-12-01
|
| Series: | Annals of Medicine |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2022.2136400 |
| _version_ | 1798029183589285888 |
|---|---|
| author | Kaiqi Wu Binin Yin Shuai Li Xiaojun Zhu Bo Zhu |
| author_facet | Kaiqi Wu Binin Yin Shuai Li Xiaojun Zhu Bo Zhu |
| author_sort | Kaiqi Wu |
| collection | DOAJ |
| description | Background Intrahepatic cholestasis of pregnancy (ICP) is the most common pregnancy-related liver disorder and may cause adverse perinatal outcomes. This large cross-sectional retrospective study aimed to evaluate the prevalence and related risk factors of ICP and determine the adverse perinatal outcomes.Methods This large cohort study from 1 January 2018 to 31 December 2019, included 39,742 eligible pregnant women. Data were extracted from the institutional electronic medical record database and analyzed using univariate and multivariate logistic regression models to determine the risk factors and adverse perinatal outcomes of ICP.Results The overall prevalence of ICP was 3.81%. It was significantly higher in hepatitis B surface antigen (HBsAg) positive than negative women in all age groups, and in women with pre-pregnancy BMI underweight and obesity aged <25 years and ≥35 years than the other age groups. Multivariate logistic regression models showed an increased risk of ICP associated with maternal age <25 years and ≥35 years, pre-pregnancy underweight and obesity, HBsAg positive status, twin pregnancies, low maternal education, inadequate gestational weight gain, multiparous, in vitro fertilization, caesarean section history and the number of abortions ≥2. The presence of ICP was associated with increased risk of maternal outcomes of caesarean section and preterm birth, and neonatal outcomes of low birth weight and neonatal unit admission in singleton and twin pregnancies.Conclusion This study identified the prevalence, possible risk factors, and associated adverse perinatal outcomes of ICP, which provides useful information for clinicians to identify, counsel, and provide timely management for women at risk.KEY MESSAGESMaternal age <25 and ≥35, pre-pregnancy BMI underweight and obesity, hepatitis B surface antigen-positive status, twin pregnancies, low maternal education, inadequate gestational weight gain, multiparous, in vitro fertilization, caesarean section history and the number of abortions ≥2 are associated with an increased risk of ICP.Further, pregnancies with ICP are associated with an increased risk of maternal outcomes of caesarean section and preterm birth and neonatal outcomes of low birth weight and neonatal unit admission in singleton and twin pregnancies. |
| first_indexed | 2024-04-11T19:21:08Z |
| format | Article |
| id | doaj.art-a8e238019a9945129ceadcbbfec523e8 |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-04-11T19:21:08Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-a8e238019a9945129ceadcbbfec523e82022-12-22T04:07:18ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602022-12-015412966297410.1080/07853890.2022.2136400Prevalence, risk factors and adverse perinatal outcomes for Chinese women with intrahepatic cholestasis of pregnancy: a large cross-sectional retrospective studyKaiqi Wu0Binin Yin1Shuai Li2Xiaojun Zhu3Bo Zhu4Department of Clinical Laboratory, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Clinical Laboratory, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Clinical Laboratory, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Obstetrics, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Clinical Laboratory, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaBackground Intrahepatic cholestasis of pregnancy (ICP) is the most common pregnancy-related liver disorder and may cause adverse perinatal outcomes. This large cross-sectional retrospective study aimed to evaluate the prevalence and related risk factors of ICP and determine the adverse perinatal outcomes.Methods This large cohort study from 1 January 2018 to 31 December 2019, included 39,742 eligible pregnant women. Data were extracted from the institutional electronic medical record database and analyzed using univariate and multivariate logistic regression models to determine the risk factors and adverse perinatal outcomes of ICP.Results The overall prevalence of ICP was 3.81%. It was significantly higher in hepatitis B surface antigen (HBsAg) positive than negative women in all age groups, and in women with pre-pregnancy BMI underweight and obesity aged <25 years and ≥35 years than the other age groups. Multivariate logistic regression models showed an increased risk of ICP associated with maternal age <25 years and ≥35 years, pre-pregnancy underweight and obesity, HBsAg positive status, twin pregnancies, low maternal education, inadequate gestational weight gain, multiparous, in vitro fertilization, caesarean section history and the number of abortions ≥2. The presence of ICP was associated with increased risk of maternal outcomes of caesarean section and preterm birth, and neonatal outcomes of low birth weight and neonatal unit admission in singleton and twin pregnancies.Conclusion This study identified the prevalence, possible risk factors, and associated adverse perinatal outcomes of ICP, which provides useful information for clinicians to identify, counsel, and provide timely management for women at risk.KEY MESSAGESMaternal age <25 and ≥35, pre-pregnancy BMI underweight and obesity, hepatitis B surface antigen-positive status, twin pregnancies, low maternal education, inadequate gestational weight gain, multiparous, in vitro fertilization, caesarean section history and the number of abortions ≥2 are associated with an increased risk of ICP.Further, pregnancies with ICP are associated with an increased risk of maternal outcomes of caesarean section and preterm birth and neonatal outcomes of low birth weight and neonatal unit admission in singleton and twin pregnancies.https://www.tandfonline.com/doi/10.1080/07853890.2022.2136400Intrahepatic cholestasis of pregnancyprevalencerisk factorsperinatal outcomes |
| spellingShingle | Kaiqi Wu Binin Yin Shuai Li Xiaojun Zhu Bo Zhu Prevalence, risk factors and adverse perinatal outcomes for Chinese women with intrahepatic cholestasis of pregnancy: a large cross-sectional retrospective study Annals of Medicine Intrahepatic cholestasis of pregnancy prevalence risk factors perinatal outcomes |
| title | Prevalence, risk factors and adverse perinatal outcomes for Chinese women with intrahepatic cholestasis of pregnancy: a large cross-sectional retrospective study |
| title_full | Prevalence, risk factors and adverse perinatal outcomes for Chinese women with intrahepatic cholestasis of pregnancy: a large cross-sectional retrospective study |
| title_fullStr | Prevalence, risk factors and adverse perinatal outcomes for Chinese women with intrahepatic cholestasis of pregnancy: a large cross-sectional retrospective study |
| title_full_unstemmed | Prevalence, risk factors and adverse perinatal outcomes for Chinese women with intrahepatic cholestasis of pregnancy: a large cross-sectional retrospective study |
| title_short | Prevalence, risk factors and adverse perinatal outcomes for Chinese women with intrahepatic cholestasis of pregnancy: a large cross-sectional retrospective study |
| title_sort | prevalence risk factors and adverse perinatal outcomes for chinese women with intrahepatic cholestasis of pregnancy a large cross sectional retrospective study |
| topic | Intrahepatic cholestasis of pregnancy prevalence risk factors perinatal outcomes |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2022.2136400 |
| work_keys_str_mv | AT kaiqiwu prevalenceriskfactorsandadverseperinataloutcomesforchinesewomenwithintrahepaticcholestasisofpregnancyalargecrosssectionalretrospectivestudy AT bininyin prevalenceriskfactorsandadverseperinataloutcomesforchinesewomenwithintrahepaticcholestasisofpregnancyalargecrosssectionalretrospectivestudy AT shuaili prevalenceriskfactorsandadverseperinataloutcomesforchinesewomenwithintrahepaticcholestasisofpregnancyalargecrosssectionalretrospectivestudy AT xiaojunzhu prevalenceriskfactorsandadverseperinataloutcomesforchinesewomenwithintrahepaticcholestasisofpregnancyalargecrosssectionalretrospectivestudy AT bozhu prevalenceriskfactorsandadverseperinataloutcomesforchinesewomenwithintrahepaticcholestasisofpregnancyalargecrosssectionalretrospectivestudy |