Immunoregulation: the interplay between metabolism and redox homeostasis
Regulatory T cells are fundamental for the induction and maintenance of immune homeostasis, with their dysfunction resulting in uncontrolled immune responses and tissue destruction predisposing to autoimmunity, transplant rejection and several inflammatory and metabolic disorders. Recent discoveries...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-11-01
|
| Series: | Frontiers in Transplantation |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/frtra.2023.1283275/full |
| _version_ | 1827160902546227200 |
|---|---|
| author | E. Perpiñán A. Sanchez-Fueyo N. Safinia |
| author_facet | E. Perpiñán A. Sanchez-Fueyo N. Safinia |
| author_sort | E. Perpiñán |
| collection | DOAJ |
| description | Regulatory T cells are fundamental for the induction and maintenance of immune homeostasis, with their dysfunction resulting in uncontrolled immune responses and tissue destruction predisposing to autoimmunity, transplant rejection and several inflammatory and metabolic disorders. Recent discoveries have demonstrated that metabolic processes and mitochondrial function are critical for the appropriate functioning of these cells in health, with their metabolic adaptation, influenced by microenvironmental factors, seen in several pathological processes. Upon activation regulatory T cells rearrange their oxidation-reduction (redox) system, which in turn supports their metabolic reprogramming, adding a layer of complexity to our understanding of cellular metabolism. Here we review the literature surrounding redox homeostasis and metabolism of regulatory T cells to highlight new mechanistic insights of these interlinked pathways in immune regulation. |
| first_indexed | 2024-03-09T14:45:37Z |
| format | Article |
| id | doaj.art-a8e3f205e3e348b497beee25c6c25797 |
| institution | Directory Open Access Journal |
| issn | 2813-2440 |
| language | English |
| last_indexed | 2025-03-21T00:20:24Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Transplantation |
| spelling | doaj.art-a8e3f205e3e348b497beee25c6c257972024-08-03T08:31:49ZengFrontiers Media S.A.Frontiers in Transplantation2813-24402023-11-01210.3389/frtra.2023.12832751283275Immunoregulation: the interplay between metabolism and redox homeostasisE. PerpiñánA. Sanchez-FueyoN. SafiniaRegulatory T cells are fundamental for the induction and maintenance of immune homeostasis, with their dysfunction resulting in uncontrolled immune responses and tissue destruction predisposing to autoimmunity, transplant rejection and several inflammatory and metabolic disorders. Recent discoveries have demonstrated that metabolic processes and mitochondrial function are critical for the appropriate functioning of these cells in health, with their metabolic adaptation, influenced by microenvironmental factors, seen in several pathological processes. Upon activation regulatory T cells rearrange their oxidation-reduction (redox) system, which in turn supports their metabolic reprogramming, adding a layer of complexity to our understanding of cellular metabolism. Here we review the literature surrounding redox homeostasis and metabolism of regulatory T cells to highlight new mechanistic insights of these interlinked pathways in immune regulation.https://www.frontiersin.org/articles/10.3389/frtra.2023.1283275/fullregulatory T cellsreactive oxygen speciesanti-oxidantsNRF2mTOR |
| spellingShingle | E. Perpiñán A. Sanchez-Fueyo N. Safinia Immunoregulation: the interplay between metabolism and redox homeostasis Frontiers in Transplantation regulatory T cells reactive oxygen species anti-oxidants NRF2 mTOR |
| title | Immunoregulation: the interplay between metabolism and redox homeostasis |
| title_full | Immunoregulation: the interplay between metabolism and redox homeostasis |
| title_fullStr | Immunoregulation: the interplay between metabolism and redox homeostasis |
| title_full_unstemmed | Immunoregulation: the interplay between metabolism and redox homeostasis |
| title_short | Immunoregulation: the interplay between metabolism and redox homeostasis |
| title_sort | immunoregulation the interplay between metabolism and redox homeostasis |
| topic | regulatory T cells reactive oxygen species anti-oxidants NRF2 mTOR |
| url | https://www.frontiersin.org/articles/10.3389/frtra.2023.1283275/full |
| work_keys_str_mv | AT eperpinan immunoregulationtheinterplaybetweenmetabolismandredoxhomeostasis AT asanchezfueyo immunoregulationtheinterplaybetweenmetabolismandredoxhomeostasis AT nsafinia immunoregulationtheinterplaybetweenmetabolismandredoxhomeostasis |