Streptococcus pneumoniae as cause of infection in infants less than 60 days of age: serotypes and antimicrobial susceptibility
Objective: The aim of this study was to determine the distribution of serotypes and the antimicrobial susceptibilities of Streptococcus pneumoniae clinical isolates causing invasive and non-invasive disease in children aged ≤60 days in hospitals in Mexico. Methods: A 15-year retrospective study was...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-01-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971215002829 |
| _version_ | 1819094232423464960 |
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| author | Araceli Soto-Noguerón María Noemí Carnalla-Barajas Fortino Solórzano-Santos José Luis Arrendondo-García Patricia Arzate-Barbosa Juan Carlos Tinoco-Favila Azarell Anzurez-Gutiérrez Gabriela Echániz-Aviles |
| author_facet | Araceli Soto-Noguerón María Noemí Carnalla-Barajas Fortino Solórzano-Santos José Luis Arrendondo-García Patricia Arzate-Barbosa Juan Carlos Tinoco-Favila Azarell Anzurez-Gutiérrez Gabriela Echániz-Aviles |
| author_sort | Araceli Soto-Noguerón |
| collection | DOAJ |
| description | Objective: The aim of this study was to determine the distribution of serotypes and the antimicrobial susceptibilities of Streptococcus pneumoniae clinical isolates causing invasive and non-invasive disease in children aged ≤60 days in hospitals in Mexico.
Methods: A 15-year retrospective study was conducted for the period 2000 to 2014. Pneumococcal clinical isolates were serotyped by Quellung reaction, and antimicrobial susceptibility testing was performed with the broth microdilution method.
Results: A total of 126 pneumococcal isolates were collected. Pneumonia was the most frequent diagnosis (40.5%), followed by meningitis (29.4%), septicemia (16.7%), and other clinical entities, including otitis media and conjunctivitis (13.5%). The most frequent serotypes before the introduction of heptavalent pneumococcal conjugate vaccine (PCV7) were 19F, 23F, 7F, and 35B. Serotypes 3, 6A, 10A, 12F, and 15A/B increased after the introduction of PCV7. Serotype 19A was isolated most frequently in the pneumonia and meningitis cases only after the introduction of PCV7, and it displayed a high resistance to penicillin.
Conclusions: Although the number of infections in infants aged ≤60 days was low, such infections were not unusual events. New vaccination strategies should be evaluated to limit the risks in this age group. |
| first_indexed | 2024-12-21T23:24:08Z |
| format | Article |
| id | doaj.art-a8e5eca94d894765a434c656f398ed0d |
| institution | Directory Open Access Journal |
| issn | 1201-9712 1878-3511 |
| language | English |
| last_indexed | 2024-12-21T23:24:08Z |
| publishDate | 2016-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-a8e5eca94d894765a434c656f398ed0d2022-12-21T18:46:43ZengElsevierInternational Journal of Infectious Diseases1201-97121878-35112016-01-0142C697310.1016/j.ijid.2015.12.001Streptococcus pneumoniae as cause of infection in infants less than 60 days of age: serotypes and antimicrobial susceptibilityAraceli Soto-Noguerón0María Noemí Carnalla-Barajas1Fortino Solórzano-Santos2José Luis Arrendondo-García3Patricia Arzate-Barbosa4Juan Carlos Tinoco-Favila5Azarell Anzurez-Gutiérrez6Gabriela Echániz-Aviles7Instituto Nacional de Salud Pública, Avenida Universidad 655, Cuernavaca, Morelos 62100, MexicoInstituto Nacional de Salud Pública, Avenida Universidad 655, Cuernavaca, Morelos 62100, MexicoUnidad Médica de Alta Especialidad, Hospital de Pediatría Centro Médico Nacional SXXI, Instituto Mexicano del Seguro Social, Mexico City, MexicoInstituto Nacional de Pediatría, Insurgentes Cuicuilco, Mexico City, MexicoInstituto Nacional de Pediatría, Insurgentes Cuicuilco, Mexico City, MexicoHospital General de Durango, Durango, MexicoHospital General de León, Obregon, León, Guanajuato, MexicoInstituto Nacional de Salud Pública, Avenida Universidad 655, Cuernavaca, Morelos 62100, MexicoObjective: The aim of this study was to determine the distribution of serotypes and the antimicrobial susceptibilities of Streptococcus pneumoniae clinical isolates causing invasive and non-invasive disease in children aged ≤60 days in hospitals in Mexico. Methods: A 15-year retrospective study was conducted for the period 2000 to 2014. Pneumococcal clinical isolates were serotyped by Quellung reaction, and antimicrobial susceptibility testing was performed with the broth microdilution method. Results: A total of 126 pneumococcal isolates were collected. Pneumonia was the most frequent diagnosis (40.5%), followed by meningitis (29.4%), septicemia (16.7%), and other clinical entities, including otitis media and conjunctivitis (13.5%). The most frequent serotypes before the introduction of heptavalent pneumococcal conjugate vaccine (PCV7) were 19F, 23F, 7F, and 35B. Serotypes 3, 6A, 10A, 12F, and 15A/B increased after the introduction of PCV7. Serotype 19A was isolated most frequently in the pneumonia and meningitis cases only after the introduction of PCV7, and it displayed a high resistance to penicillin. Conclusions: Although the number of infections in infants aged ≤60 days was low, such infections were not unusual events. New vaccination strategies should be evaluated to limit the risks in this age group.http://www.sciencedirect.com/science/article/pii/S1201971215002829Streptococcus pneumoniaeSerotypesInvasive pneumococcal diseasesNewbornsPneumococcal vaccinesAntimicrobial susceptibility |
| spellingShingle | Araceli Soto-Noguerón María Noemí Carnalla-Barajas Fortino Solórzano-Santos José Luis Arrendondo-García Patricia Arzate-Barbosa Juan Carlos Tinoco-Favila Azarell Anzurez-Gutiérrez Gabriela Echániz-Aviles Streptococcus pneumoniae as cause of infection in infants less than 60 days of age: serotypes and antimicrobial susceptibility International Journal of Infectious Diseases Streptococcus pneumoniae Serotypes Invasive pneumococcal diseases Newborns Pneumococcal vaccines Antimicrobial susceptibility |
| title | Streptococcus pneumoniae as cause of infection in infants less than 60 days of age: serotypes and antimicrobial susceptibility |
| title_full | Streptococcus pneumoniae as cause of infection in infants less than 60 days of age: serotypes and antimicrobial susceptibility |
| title_fullStr | Streptococcus pneumoniae as cause of infection in infants less than 60 days of age: serotypes and antimicrobial susceptibility |
| title_full_unstemmed | Streptococcus pneumoniae as cause of infection in infants less than 60 days of age: serotypes and antimicrobial susceptibility |
| title_short | Streptococcus pneumoniae as cause of infection in infants less than 60 days of age: serotypes and antimicrobial susceptibility |
| title_sort | streptococcus pneumoniae as cause of infection in infants less than 60 days of age serotypes and antimicrobial susceptibility |
| topic | Streptococcus pneumoniae Serotypes Invasive pneumococcal diseases Newborns Pneumococcal vaccines Antimicrobial susceptibility |
| url | http://www.sciencedirect.com/science/article/pii/S1201971215002829 |
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