Association of dementia with immunoglobulin G N-glycans in a Chinese Han Population
Abstract Immunoglobulin G (IgG) functionality can drastically change from anti- to proinflammatory by alterations in the IgG N-glycan patterns. Our previous studies have demonstrated that IgG N-glycans associated with the risk factors of dementia, such as aging, dyslipidemia, type 2 diabetes mellitu...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-02-01
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| Series: | npj Aging and Mechanisms of Disease |
| Online Access: | https://doi.org/10.1038/s41514-021-00055-w |
| _version_ | 1818431873500577792 |
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| author | Xiaoyu Zhang Hui Yuan Jihui Lyu Xiaoni Meng Qiuyue Tian Yuejin Li Jie Zhang Xizhu Xu Jing Su Haifeng Hou Dong Li Baoliang Sun Wei Wang Youxin Wang |
| author_facet | Xiaoyu Zhang Hui Yuan Jihui Lyu Xiaoni Meng Qiuyue Tian Yuejin Li Jie Zhang Xizhu Xu Jing Su Haifeng Hou Dong Li Baoliang Sun Wei Wang Youxin Wang |
| author_sort | Xiaoyu Zhang |
| collection | DOAJ |
| description | Abstract Immunoglobulin G (IgG) functionality can drastically change from anti- to proinflammatory by alterations in the IgG N-glycan patterns. Our previous studies have demonstrated that IgG N-glycans associated with the risk factors of dementia, such as aging, dyslipidemia, type 2 diabetes mellitus, hypertension, and ischemic stroke. Therefore, the aim is to investigate whether the effects of IgG N-glycan profiles on dementia exists in a Chinese Han population. A case–control study, including 81 patients with dementia, 81 age- and gender-matched controls with normal cognitive functioning (NC) and 108 non-matched controls with mild cognitive impairment (MCI) was performed. Plasma IgG N-glycans were separated by ultra-performance liquid chromatography. Fourteen glycan peaks reflecting decreased of sialylation and core fucosylation, and increased bisecting N-acetylglucosamine (GlcNAc) N-glycan structures were of statistically significant differences between dementia and NC groups after controlling for confounders (p < 0.05; q < 0.05). Similarly, the differences for these 14 initial glycans were statistically significant between AD and NC groups after adjusting for the effects of confounders (p < 0.05; q < 0.05). The area under the receiver operating curve (AUC) value of the model consisting of GP8, GP9, and GP14 was determined to distinguish dementia from NC group as 0.876 [95% confidence interval (CI): 0.815–0.923] and distinguish AD from NC group as 0.887 (95% CI: 0.819–0.936). Patients with dementia were of an elevated proinflammatory activity via the significant changes of IgG glycome. Therefore, IgG N-glycans might contribute to be potential novel biomarkers for the neurodegenerative process risk assessment of dementia. |
| first_indexed | 2024-12-14T15:56:13Z |
| format | Article |
| id | doaj.art-a8e693e8a0ec4afabaff9909a3db5698 |
| institution | Directory Open Access Journal |
| issn | 2056-3973 |
| language | English |
| last_indexed | 2024-12-14T15:56:13Z |
| publishDate | 2021-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Aging and Mechanisms of Disease |
| spelling | doaj.art-a8e693e8a0ec4afabaff9909a3db56982022-12-21T22:55:15ZengNature Portfolionpj Aging and Mechanisms of Disease2056-39732021-02-017111210.1038/s41514-021-00055-wAssociation of dementia with immunoglobulin G N-glycans in a Chinese Han PopulationXiaoyu Zhang0Hui Yuan1Jihui Lyu2Xiaoni Meng3Qiuyue Tian4Yuejin Li5Jie Zhang6Xizhu Xu7Jing Su8Haifeng Hou9Dong Li10Baoliang Sun11Wei Wang12Youxin Wang13Department of Epidemiology and Health Statistics, School of Public Health, Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical UniversityDepartment of Neurology, The Second Affiliated Hospital of Shandong First Medical UniversityCenter for Cognitive Disorders, Beijing Geriatric HospitalDepartment of Epidemiology and Health Statistics, School of Public Health, Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical UniversitySchool of public health, Shandong First Medical University & Shandong Academy of Medical SciencesDepartment of Epidemiology and Health Statistics, School of Public Health, Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical UniversitySchool of public health, Shandong First Medical University & Shandong Academy of Medical SciencesDepartment of Geriatrics, Tai’an City Central HospitalSchool of public health, Shandong First Medical University & Shandong Academy of Medical SciencesSchool of public health, Shandong First Medical University & Shandong Academy of Medical SciencesKey Lab of Cerebral Microcirculation in Universities of Shandong, Shandong First Medical University & Shandong Academy of Medical SciencesDepartment of Epidemiology and Health Statistics, School of Public Health, Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical UniversityAbstract Immunoglobulin G (IgG) functionality can drastically change from anti- to proinflammatory by alterations in the IgG N-glycan patterns. Our previous studies have demonstrated that IgG N-glycans associated with the risk factors of dementia, such as aging, dyslipidemia, type 2 diabetes mellitus, hypertension, and ischemic stroke. Therefore, the aim is to investigate whether the effects of IgG N-glycan profiles on dementia exists in a Chinese Han population. A case–control study, including 81 patients with dementia, 81 age- and gender-matched controls with normal cognitive functioning (NC) and 108 non-matched controls with mild cognitive impairment (MCI) was performed. Plasma IgG N-glycans were separated by ultra-performance liquid chromatography. Fourteen glycan peaks reflecting decreased of sialylation and core fucosylation, and increased bisecting N-acetylglucosamine (GlcNAc) N-glycan structures were of statistically significant differences between dementia and NC groups after controlling for confounders (p < 0.05; q < 0.05). Similarly, the differences for these 14 initial glycans were statistically significant between AD and NC groups after adjusting for the effects of confounders (p < 0.05; q < 0.05). The area under the receiver operating curve (AUC) value of the model consisting of GP8, GP9, and GP14 was determined to distinguish dementia from NC group as 0.876 [95% confidence interval (CI): 0.815–0.923] and distinguish AD from NC group as 0.887 (95% CI: 0.819–0.936). Patients with dementia were of an elevated proinflammatory activity via the significant changes of IgG glycome. Therefore, IgG N-glycans might contribute to be potential novel biomarkers for the neurodegenerative process risk assessment of dementia.https://doi.org/10.1038/s41514-021-00055-w |
| spellingShingle | Xiaoyu Zhang Hui Yuan Jihui Lyu Xiaoni Meng Qiuyue Tian Yuejin Li Jie Zhang Xizhu Xu Jing Su Haifeng Hou Dong Li Baoliang Sun Wei Wang Youxin Wang Association of dementia with immunoglobulin G N-glycans in a Chinese Han Population npj Aging and Mechanisms of Disease |
| title | Association of dementia with immunoglobulin G N-glycans in a Chinese Han Population |
| title_full | Association of dementia with immunoglobulin G N-glycans in a Chinese Han Population |
| title_fullStr | Association of dementia with immunoglobulin G N-glycans in a Chinese Han Population |
| title_full_unstemmed | Association of dementia with immunoglobulin G N-glycans in a Chinese Han Population |
| title_short | Association of dementia with immunoglobulin G N-glycans in a Chinese Han Population |
| title_sort | association of dementia with immunoglobulin g n glycans in a chinese han population |
| url | https://doi.org/10.1038/s41514-021-00055-w |
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