Preventing Myocardial Injury Following Non-Cardiac Surgery: A Potential Role for Preoperative Antioxidant Therapy with Ubiquinone
Over 240 million non-cardiac operations occur each year and are associated with a 15–20% incidence of adverse perioperative cardiovascular events. Unfortunately, preoperative therapies that have been useful for chronic ischemic heart diseases, such as coronary artery revascularization, antiplatelet...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/2/276 |
| _version_ | 1797411579042463744 |
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| author | Qun Chen Steven Qi Laura Hocum-Stone Edward Lesnefsky Rosemary F. Kelly Edward O. McFalls |
| author_facet | Qun Chen Steven Qi Laura Hocum-Stone Edward Lesnefsky Rosemary F. Kelly Edward O. McFalls |
| author_sort | Qun Chen |
| collection | DOAJ |
| description | Over 240 million non-cardiac operations occur each year and are associated with a 15–20% incidence of adverse perioperative cardiovascular events. Unfortunately, preoperative therapies that have been useful for chronic ischemic heart diseases, such as coronary artery revascularization, antiplatelet agents, and beta-blockers have failed to improve outcomes. In a pre-clinical swine model of ischemic heart disease, we showed that daily administration of ubiquinone (coenzyme Q<sub>10</sub>, CoQ<sub>10</sub>) enhances the antioxidant status of mitochondria within chronically ischemic heart tissue, potentially via a PGC1α-dependent mechanism. In a randomized controlled trial, among high-risk patients undergoing elective vascular surgery, we showed that NT Pro-BNP levels are an important means of risk-stratification during the perioperative period and can be lowered with administration of CoQ<sub>10</sub> (400 mg/day) for 3 days prior to surgery. The review provides background information for the role of oxidant stress and inflammation during high-risk operations and the potential novel application of ubiquinone as a preoperative antioxidant therapy that might reduce perioperative adverse cardiovascular outcomes. |
| first_indexed | 2024-03-09T04:47:09Z |
| format | Article |
| id | doaj.art-a8e72c6586884ea49598b65c16bd7126 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T04:47:09Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-a8e72c6586884ea49598b65c16bd71262023-12-03T13:14:05ZengMDPI AGAntioxidants2076-39212021-02-0110227610.3390/antiox10020276Preventing Myocardial Injury Following Non-Cardiac Surgery: A Potential Role for Preoperative Antioxidant Therapy with UbiquinoneQun Chen0Steven Qi1Laura Hocum-Stone2Edward Lesnefsky3Rosemary F. Kelly4Edward O. McFalls5Virginia Commonwealth University Medical Center, Richmond, VA 23219, USACardiology-Cardiac Surgery, University of Minnesota, Minneapolis, MN 55455, USACardiology-Cardiac Surgery, University of Minnesota, Minneapolis, MN 55455, USAVirginia Commonwealth University Medical Center, Richmond, VA 23219, USACardiology-Cardiac Surgery, University of Minnesota, Minneapolis, MN 55455, USACardiology-Cardiac Surgery, University of Minnesota, Minneapolis, MN 55455, USAOver 240 million non-cardiac operations occur each year and are associated with a 15–20% incidence of adverse perioperative cardiovascular events. Unfortunately, preoperative therapies that have been useful for chronic ischemic heart diseases, such as coronary artery revascularization, antiplatelet agents, and beta-blockers have failed to improve outcomes. In a pre-clinical swine model of ischemic heart disease, we showed that daily administration of ubiquinone (coenzyme Q<sub>10</sub>, CoQ<sub>10</sub>) enhances the antioxidant status of mitochondria within chronically ischemic heart tissue, potentially via a PGC1α-dependent mechanism. In a randomized controlled trial, among high-risk patients undergoing elective vascular surgery, we showed that NT Pro-BNP levels are an important means of risk-stratification during the perioperative period and can be lowered with administration of CoQ<sub>10</sub> (400 mg/day) for 3 days prior to surgery. The review provides background information for the role of oxidant stress and inflammation during high-risk operations and the potential novel application of ubiquinone as a preoperative antioxidant therapy that might reduce perioperative adverse cardiovascular outcomes.https://www.mdpi.com/2076-3921/10/2/276CoQ<sub>10</sub>ubiquinonemyocardial injurytroponinBNPvascular surgery |
| spellingShingle | Qun Chen Steven Qi Laura Hocum-Stone Edward Lesnefsky Rosemary F. Kelly Edward O. McFalls Preventing Myocardial Injury Following Non-Cardiac Surgery: A Potential Role for Preoperative Antioxidant Therapy with Ubiquinone Antioxidants CoQ<sub>10</sub> ubiquinone myocardial injury troponin BNP vascular surgery |
| title | Preventing Myocardial Injury Following Non-Cardiac Surgery: A Potential Role for Preoperative Antioxidant Therapy with Ubiquinone |
| title_full | Preventing Myocardial Injury Following Non-Cardiac Surgery: A Potential Role for Preoperative Antioxidant Therapy with Ubiquinone |
| title_fullStr | Preventing Myocardial Injury Following Non-Cardiac Surgery: A Potential Role for Preoperative Antioxidant Therapy with Ubiquinone |
| title_full_unstemmed | Preventing Myocardial Injury Following Non-Cardiac Surgery: A Potential Role for Preoperative Antioxidant Therapy with Ubiquinone |
| title_short | Preventing Myocardial Injury Following Non-Cardiac Surgery: A Potential Role for Preoperative Antioxidant Therapy with Ubiquinone |
| title_sort | preventing myocardial injury following non cardiac surgery a potential role for preoperative antioxidant therapy with ubiquinone |
| topic | CoQ<sub>10</sub> ubiquinone myocardial injury troponin BNP vascular surgery |
| url | https://www.mdpi.com/2076-3921/10/2/276 |
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