Effect of coadministration of rifampicin on the pharmacokinetics of linezolid: clinical and animal studies

Effect of coadministration of rifampicin on the pharmacokinetics of linezolid: clinical and animal studies

Abstract Background Combination therapy of linezolid (LZD) and rifampicin (RFP) may be more effective than monotherapy for treating gram-positive bacterial infections, but several studies have suggested that RFP decreases LZD exposures, thereby increasing the risk of therapeutic failure and emergenc...

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Main Authors: Satsuki Hashimoto, Kyoko Honda, Kohei Fujita, Yuka Miyachi, Kazuya Isoda, Ko Misaka, Yukio Suga, Satoshi Kato, Hiroyuki Tsuchiya, Yukio Kato, Masaki Okajima, Takumi Taniguchi, Tsutomu Shimada, Yoshimichi Sai
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Journal of Pharmaceutical Health Care and Sciences
Subjects:
Linezolid
Rifampicin
Drug-drug interaction
Therapeutic drug monitoring
Pharmacokinetics
Adverse event
Online Access:http://link.springer.com/article/10.1186/s40780-018-0123-1

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