Alisol A 24-Acetate Prevents Hepatic Steatosis and Metabolic Disorders in HepG2 Cells

Alisol A 24-Acetate Prevents Hepatic Steatosis and Metabolic Disorders in HepG2 Cells

Background: Non-alcoholic fatty liver disease (NAFLD) is closely associated with metabolic disorders including hepatic lipid accumulation and inflammation. Alisol A 24-acetate, a triterpene from Alismatis rhizome, has multiple biologic activities such as hypolipidemic, anti-inflammatory and anti-dia...

Full description

Bibliographic Details
Main Authors:	Lu Zeng, WaiJiao Tang, JinJin Yin, LiJuan Feng, Yabing Li, Xiaorui Yao, BenJie Zhou
Format:	Article
Language:	English
Published:	Cell Physiol Biochem Press GmbH & Co KG 2016-11-01
Series:	Cellular Physiology and Biochemistry
Subjects:	Alisol A 24-acetate Hepatic steatosis Lipid accumulation Inflammation Adiponectin AMPKα PPARα
Online Access:	http://www.karger.com/Article/FullText/452560

Similar Items

Alisol A Alleviates Arterial Plaque by Activating AMPK/SIRT1 Signaling Pathway in apoE-Deficient Mice
by: Ke Wang, et al.
Published: (2020-11-01)

A UFLC/MS/MS method for simultaneous quantitation of alisol A and alisol B 23-acetate from Alisma orientale (Sam.) Juz. in rat plasma
by: Yaowen Zhang, et al.
Published: (2014-10-01)

Alisol A 24‐acetate ameliorates osteoarthritis progression by inhibiting reactive oxygen species and inflammatory response through the AMPK/mTOR pathway
by: Guosong Xu, et al.
Published: (2023-05-01)

Neuroprotective effects of alisol A 24-acetate on cerebral ischaemia–reperfusion injury are mediated by regulating the PI3K/AKT pathway
by: Taotao Lu, et al.
Published: (2022-02-01)

Alisol A 24-acetate stimulates lipolysis in 3 T3-L1 adipocytes
by: Hai-xia Lou, et al.
Published: (2021-04-01)

The roles of serine hydrolases and serum albumin in alisol B 23-acetate hydrolysis in humans
by: Tiantian Zhang, et al.
Published: (2023-04-01)

Alisol F 24 Acetate Enhances Chemosensitivity and Apoptosis of MCF-7/DOX Cells by Inhibiting P-Glycoprotein-Mediated Drug Efflux
by: Guixiang Pan, et al.
Published: (2016-02-01)

Alisol B Alleviates Hepatocyte Lipid Accumulation and Lipotoxicity via Regulating RARα-PPARγ-CD36 Cascade and Attenuates Non-Alcoholic Steatohepatitis in Mice
by: Zhuohui Zhao, et al.
Published: (2022-06-01)

The Mechanism of Alisol B23 Acetate Inhibiting Lung Cancer: Targeted Regulation of CD11b/CD18 to Influence Macrophage Polarization
by: Chen Y, et al.
Published: (2022-10-01)

Potential of alisols as cancer therapeutic agents: Investigating molecular mechanisms, pharmacokinetics and metabolism
by: Yinqi Wu, et al.
Published: (2023-12-01)

Alisol B 23-Acetate Ameliorates Lipopolysaccharide-Induced Intestinal Barrier Dysfunction by Inhibiting TLR4-NOX1/ROS Signaling Pathway in Caco-2 Cells
by: Fan Xia, et al.
Published: (2022-06-01)

Inhibitory Effect of Styrylpyrone Extract of <i>Phellinus linteus</i> on Hepatic Steatosis in HepG2 Cells
by: Chun-Hung Chiu, et al.
Published: (2023-02-01)

Extraction process optimization of alisol B 23-acetate from Alismatis Rhizoma and its protection against carbon tetrachloride-induced acute liver injury
by: Peng Lei, et al.
Published: (2024-01-01)

Protective roles of adiponectin and molecular signatures of HNF4α and PPARα as downstream targets of adiponectin in pancreatic β cells
by: Toshiharu Onodera, et al.
Published: (2023-12-01)

Liraglutide Alleviates Hepatic Steatosis and Liver Injury in T2MD Rats via a GLP-1R Dependent AMPK Pathway
by: Rui Zhou, et al.
Published: (2021-03-01)

Taurine alleviated hepatic steatosis in oleic acid-treated-HepG2 cells and rats fed a high-fat diet
by: Qi Song, et al.
Published: (2023-06-01)

Naringenin attenuates hepatitis B virus X protein-induced hepatic steatosis
by: Hung-Jen Lin, et al.
Published: (2017-11-01)

Pharmacological Properties and Molecular Targets of Alisol Triterpenoids from <i>Alismatis</i> Rhizoma
by: Christian Bailly
Published: (2022-08-01)

Tumor necrosis factor-α reduces adiponectin production by decreasing transcriptional activity of peroxisome proliferator-activated receptor-γ in calf adipocytes
by: Hao Yu, et al.
Published: (2023-07-01)

Prophylactic effect of Trigonella foenum-graecum L. seed extract on inflammatory markers and histopathological changes in high-fat-fed ovariectomized rats
by: Takkella Nagamma, et al.
Published: (2022-03-01)

PM2.5 induced liver lipid metabolic disorders in C57BL/6J mice
by: Chenxiao Zhang, et al.
Published: (2023-09-01)

Yield trends in the long-term crop rotation with organic and inorganic fertilisers on Alisols in Mata (Rwanda)
by: Neel H., et al.
Published: (2006-01-01)

Vitamin D improves hepatic steatosis in NAFLD via regulation of fatty acid uptake and β-oxidation
by: Tingwan Du, et al.
Published: (2023-03-01)

Le Carbone prevents liver damage in non-alcoholic steatohepatitis-hepatocellular carcinoma mouse model via AMPKα-SIRT1 signaling pathway activation
by: Mst. Rejina Afrin, et al.
Published: (2021-01-01)

Garcinia Biflavonoid 1 Improves Lipid Metabolism in HepG2 Cells via Regulating PPARα
by: Hai-Xin Chen, et al.
Published: (2022-03-01)

Ameliorative effect of dieckol-enriched extraction from Laminaria japonica on hepatic steatosis induced by a high-fat diet via β-oxidation pathway in ICR mice
by: Yixiang Liu, et al.
Published: (2019-07-01)

Polyphenolic compounds from Idesia polycarpa Maxim. fruits ameliorate non-alcoholic fatty liver disease by modulating lipid metabolism in oleic acid-induced HepG2 cells and high-fat diet-induced mice
by: Lei Huang, et al.
Published: (2023-09-01)

Equol intervention ameliorates steatosis in HepG2 cells induced by sodium oleate
by: ZHANG Guiming, et al.
Published: (2023-02-01)

New insights into the anti-hepatoma mechanism of Alisol G-metal ions complexes based on c-myc DNA
by: Fei Xu, et al.
Published: (2021-12-01)

Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together?
by: Michel Abou-Samra, et al.
Published: (2020-04-01)

ACACA reduces lipid accumulation through dual regulation of lipid metabolism and mitochondrial function via AMPK- PPARα- CPT1A axis
by: Jian Dong, et al.
Published: (2024-02-01)

PPARβ/δ Agonist GW501516 Inhibits Tumorigenicity of Undifferentiated Nasopharyngeal Carcinoma in C666-1 Cells by Promoting Apoptosis
by: Yangyang Ji, et al.
Published: (2018-06-01)

Anti-inflammatory effect of lactobacilli bacteria on HepG2 cells is through cross-regulation of TLR4 and NOD2 signalling
by: Yi-Heng Chiu, et al.
Published: (2013-04-01)

Saroglitazar improved hepatic steatosis and fibrosis by modulating inflammatory cytokines and adiponectin in an animal model of non-alcoholic steatohepatitis
by: Rasoul Akbari, et al.
Published: (2021-10-01)

Dynamic repression by BCL6 controls the genome-wide liver response to fasting and steatosis
by: Meredith A Sommars, et al.
Published: (2019-04-01)

Protostane and Fusidane Triterpenes: A Mini-Review
by: Chun-Tao Che, et al.
Published: (2013-04-01)

Short-Chain Fatty Acids (Except Hexanoic Acid) Lower NF-kB Transactivation, Which Rescues Inflammation-Induced Decreased Apolipoprotein A-I Transcription in HepG2 Cells
by: Jehad Z. Tayyeb, et al.
Published: (2020-07-01)

Anthelmintics nitazoxanide protects against experimental hyperlipidemia and hepatic steatosis in hamsters and mice
by: Fengfeng Li, et al.
Published: (2022-03-01)

Fenofibrate Regulates Visceral Obesity and Nonalcoholic Steatohepatitis in Obese Female Ovariectomized C57BL/6J Mice
by: Yujin Shin, et al.
Published: (2021-04-01)

Allantoin improves methionine-choline deficient diet-induced nonalcoholic steatohepatitis in mice through involvement in endoplasmic reticulum stress and hepatocytes apoptosis-related genes expressions
by: Tahereh Komeili Movahhed, et al.
Published: (2019-07-01)