IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling

IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling

Summary: Interleukin (IL)-6 engages similar signaling mechanisms to leptin. Here, we find that central application of IL-6 in mice suppresses feeding and improves glucose tolerance. In contrast to leptin, whose action is attenuated in obesity, the ability of IL-6 to suppress feeding is enhanced in o...

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Bibliographic Details
Main Authors: Katharina Timper, Jesse Lee Denson, Sophie Marie Steculorum, Christian Heilinger, Linda Engström-Ruud, Claudia Maria Wunderlich, Stefan Rose-John, F. Thomas Wunderlich, Jens Claus Brüning
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717303893

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