The Pattern of Brain-Derived Neurotrophic Factor Gene Expression in the Hippocampus of Diabetic Rats
Objective(s)The aim of this study was to evaluate the effects of regular exercise in preventing diabetes complication in the hippocampus of streptozotocin (STZ)-induced diabetic rat.Materials and MethodsA total of 48 male wistar rats were divided into four groups (control, control exercise, diabetic...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2010-06-01
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| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | http://www.mums.ac.ir/shares/basic_medical/basicmedjou/89/summer/a12.pdf |
| _version_ | 1819199151069462528 |
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| author | Iraj Salehi Safar Farajnia Mustafa Mohammadi Masoud Sabouri Ghannad |
| author_facet | Iraj Salehi Safar Farajnia Mustafa Mohammadi Masoud Sabouri Ghannad |
| author_sort | Iraj Salehi |
| collection | DOAJ |
| description | Objective(s)The aim of this study was to evaluate the effects of regular exercise in preventing diabetes complication in the hippocampus of streptozotocin (STZ)-induced diabetic rat.Materials and MethodsA total of 48 male wistar rats were divided into four groups (control, control exercise, diabetic and diabetic exercise). Diabetes was induced by injection of single dose of STZ. Exercise was performed for one hr every day, over a period of 8 weeks. The antioxidant enzymes (SOD, GPX, CAT and GR) and oxidant indexes with brain-derived neurotrophic factor (BDNF) protein and its mRNA and apoptosis were measured in hippocampus of rats. ResultsA significant decrease in antioxidant enzymes activities and increased malondialdehyde (MDA) level were observed in diabetic rats (P= 0.004). In response to exercise, antioxidant enzymes activities increased (P= 0.004). In contrast, MDA level decreased in diabetic rats (P= 0.004). Induction of diabetes caused an increase of BDNF protein and its mRNA expression. In response to exercise, BDNF protein and its mRNA expression reduced in hippocampus of diabetic rats. ConclusionDiabetes induced oxidative stress and increased BDNF gene expression. Exercise ameliorated oxidative stress and decreased BDNF gene expression. |
| first_indexed | 2024-12-23T03:11:46Z |
| format | Article |
| id | doaj.art-a8eda242078649219f554ad80ba26c3e |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-12-23T03:11:46Z |
| publishDate | 2010-06-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-a8eda242078649219f554ad80ba26c3e2022-12-21T18:02:14ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742010-06-011346The Pattern of Brain-Derived Neurotrophic Factor Gene Expression in the Hippocampus of Diabetic RatsIraj SalehiSafar FarajniaMustafa MohammadiMasoud Sabouri GhannadObjective(s)The aim of this study was to evaluate the effects of regular exercise in preventing diabetes complication in the hippocampus of streptozotocin (STZ)-induced diabetic rat.Materials and MethodsA total of 48 male wistar rats were divided into four groups (control, control exercise, diabetic and diabetic exercise). Diabetes was induced by injection of single dose of STZ. Exercise was performed for one hr every day, over a period of 8 weeks. The antioxidant enzymes (SOD, GPX, CAT and GR) and oxidant indexes with brain-derived neurotrophic factor (BDNF) protein and its mRNA and apoptosis were measured in hippocampus of rats. ResultsA significant decrease in antioxidant enzymes activities and increased malondialdehyde (MDA) level were observed in diabetic rats (P= 0.004). In response to exercise, antioxidant enzymes activities increased (P= 0.004). In contrast, MDA level decreased in diabetic rats (P= 0.004). Induction of diabetes caused an increase of BDNF protein and its mRNA expression. In response to exercise, BDNF protein and its mRNA expression reduced in hippocampus of diabetic rats. ConclusionDiabetes induced oxidative stress and increased BDNF gene expression. Exercise ameliorated oxidative stress and decreased BDNF gene expression.http://www.mums.ac.ir/shares/basic_medical/basicmedjou/89/summer/a12.pdfBDNFHippocampusOxidative StressExercise |
| spellingShingle | Iraj Salehi Safar Farajnia Mustafa Mohammadi Masoud Sabouri Ghannad The Pattern of Brain-Derived Neurotrophic Factor Gene Expression in the Hippocampus of Diabetic Rats Iranian Journal of Basic Medical Sciences BDNF Hippocampus Oxidative Stress Exercise |
| title | The Pattern of Brain-Derived Neurotrophic Factor Gene Expression in the Hippocampus of Diabetic Rats |
| title_full | The Pattern of Brain-Derived Neurotrophic Factor Gene Expression in the Hippocampus of Diabetic Rats |
| title_fullStr | The Pattern of Brain-Derived Neurotrophic Factor Gene Expression in the Hippocampus of Diabetic Rats |
| title_full_unstemmed | The Pattern of Brain-Derived Neurotrophic Factor Gene Expression in the Hippocampus of Diabetic Rats |
| title_short | The Pattern of Brain-Derived Neurotrophic Factor Gene Expression in the Hippocampus of Diabetic Rats |
| title_sort | pattern of brain derived neurotrophic factor gene expression in the hippocampus of diabetic rats |
| topic | BDNF Hippocampus Oxidative Stress Exercise |
| url | http://www.mums.ac.ir/shares/basic_medical/basicmedjou/89/summer/a12.pdf |
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