Fighting against a protean enemy: immunosenescence, vaccines, and healthy aging
Abstract The progressive increase of the aged population worldwide mandates new strategies to ensure sustained health and well-being with age. The development of better and/or new vaccines against pathogens that affect older adults is one pivotal intervention in approaching this goal. However, the f...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-12-01
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| Series: | npj Aging and Mechanisms of Disease |
| Online Access: | https://doi.org/10.1038/s41514-017-0020-0 |
| _version_ | 1831774008258854912 |
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| author | Giuseppe Del Giudice Jörg J. Goronzy Beatrix Grubeck-Loebenstein Paul-Henri Lambert Tomas Mrkvan Jeffrey J. Stoddard T. Mark Doherty |
| author_facet | Giuseppe Del Giudice Jörg J. Goronzy Beatrix Grubeck-Loebenstein Paul-Henri Lambert Tomas Mrkvan Jeffrey J. Stoddard T. Mark Doherty |
| author_sort | Giuseppe Del Giudice |
| collection | DOAJ |
| description | Abstract The progressive increase of the aged population worldwide mandates new strategies to ensure sustained health and well-being with age. The development of better and/or new vaccines against pathogens that affect older adults is one pivotal intervention in approaching this goal. However, the functional decline of various physiological systems, including the immune system, requires novel approaches to counteract immunosenescence. Although important progress has been made in understanding the mechanisms underlying the age-related decline of the immune response to infections and vaccinations, knowledge gaps remain, both in the areas of basic and translational research. In particular, it will be important to better understand how environmental factors, such as diet, physical activity, co-morbidities, and pharmacological treatments, delay or contribute to the decline of the capability of the aging immune system to appropriately respond to infectious diseases and vaccination. Recent findings suggest that successful approaches specifically targeted to the older population can be developed, such as the high-dose and adjuvanted vaccines against seasonal influenza, the adjuvanted subunit vaccine against herpes zoster, as well as experimental interventions with immune-potentiators or immunostimulants. Learning from these first successes may pave the way to developing novel and improved vaccines for the older adults and immunocompromised. With an integrated, holistic vaccination strategy, society will offer the opportunity for an improved quality of life to the segment of the population that is going to increase most significantly in numbers and proportion over future decades. |
| first_indexed | 2024-12-22T08:46:38Z |
| format | Article |
| id | doaj.art-a8ee1fc6f7b64f2390b32b767db0e7f4 |
| institution | Directory Open Access Journal |
| issn | 2056-3973 |
| language | English |
| last_indexed | 2024-12-22T08:46:38Z |
| publishDate | 2017-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Aging and Mechanisms of Disease |
| spelling | doaj.art-a8ee1fc6f7b64f2390b32b767db0e7f42022-12-21T18:32:06ZengNature Portfolionpj Aging and Mechanisms of Disease2056-39732017-12-01411810.1038/s41514-017-0020-0Fighting against a protean enemy: immunosenescence, vaccines, and healthy agingGiuseppe Del Giudice0Jörg J. Goronzy1Beatrix Grubeck-Loebenstein2Paul-Henri Lambert3Tomas Mrkvan4Jeffrey J. Stoddard5T. Mark Doherty6GSKStanford University School of MedicineUniversity of InnsbruckUniversity of GenevaGSKGSKGSKAbstract The progressive increase of the aged population worldwide mandates new strategies to ensure sustained health and well-being with age. The development of better and/or new vaccines against pathogens that affect older adults is one pivotal intervention in approaching this goal. However, the functional decline of various physiological systems, including the immune system, requires novel approaches to counteract immunosenescence. Although important progress has been made in understanding the mechanisms underlying the age-related decline of the immune response to infections and vaccinations, knowledge gaps remain, both in the areas of basic and translational research. In particular, it will be important to better understand how environmental factors, such as diet, physical activity, co-morbidities, and pharmacological treatments, delay or contribute to the decline of the capability of the aging immune system to appropriately respond to infectious diseases and vaccination. Recent findings suggest that successful approaches specifically targeted to the older population can be developed, such as the high-dose and adjuvanted vaccines against seasonal influenza, the adjuvanted subunit vaccine against herpes zoster, as well as experimental interventions with immune-potentiators or immunostimulants. Learning from these first successes may pave the way to developing novel and improved vaccines for the older adults and immunocompromised. With an integrated, holistic vaccination strategy, society will offer the opportunity for an improved quality of life to the segment of the population that is going to increase most significantly in numbers and proportion over future decades.https://doi.org/10.1038/s41514-017-0020-0 |
| spellingShingle | Giuseppe Del Giudice Jörg J. Goronzy Beatrix Grubeck-Loebenstein Paul-Henri Lambert Tomas Mrkvan Jeffrey J. Stoddard T. Mark Doherty Fighting against a protean enemy: immunosenescence, vaccines, and healthy aging npj Aging and Mechanisms of Disease |
| title | Fighting against a protean enemy: immunosenescence, vaccines, and healthy aging |
| title_full | Fighting against a protean enemy: immunosenescence, vaccines, and healthy aging |
| title_fullStr | Fighting against a protean enemy: immunosenescence, vaccines, and healthy aging |
| title_full_unstemmed | Fighting against a protean enemy: immunosenescence, vaccines, and healthy aging |
| title_short | Fighting against a protean enemy: immunosenescence, vaccines, and healthy aging |
| title_sort | fighting against a protean enemy immunosenescence vaccines and healthy aging |
| url | https://doi.org/10.1038/s41514-017-0020-0 |
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