The roles of ERAS during cell lineage specification of mouse early embryonic development
Eras encodes a Ras-like GTPase protein that was originally identified as an embryonic stem cell-specific Ras. ERAS has been known to be required for the growth of embryonic stem cells and stimulates somatic cell reprogramming, suggesting its roles on mouse early embryonic development. We now report...
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| Format: | Article |
| Language: | English |
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The Royal Society
2015-01-01
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| Series: | Open Biology |
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| Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.150092 |
| _version_ | 1818791567268249600 |
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| author | Zhen-Ao Zhao Yang Yu Huai-Xiao Ma Xiao-Xiao Wang Xukun Lu Yanhua Zhai Xiaoxin Zhang Haibin Wang Lei Li |
| author_facet | Zhen-Ao Zhao Yang Yu Huai-Xiao Ma Xiao-Xiao Wang Xukun Lu Yanhua Zhai Xiaoxin Zhang Haibin Wang Lei Li |
| author_sort | Zhen-Ao Zhao |
| collection | DOAJ |
| description | Eras encodes a Ras-like GTPase protein that was originally identified as an embryonic stem cell-specific Ras. ERAS has been known to be required for the growth of embryonic stem cells and stimulates somatic cell reprogramming, suggesting its roles on mouse early embryonic development. We now report a dynamic expression pattern of Eras during mouse peri-implantation development: its expression increases at the blastocyst stage, and specifically decreases in E7.5 mesoderm. In accordance with its expression pattern, the increased expression of Eras promotes cell proliferation through controlling AKT activation and the commitment from ground to primed state through ERK activation in mouse embryonic stem cells; and the reduced expression of Eras facilitates primitive streak and mesoderm formation through AKT inhibition during gastrulation. The expression of Eras is finely regulated to match its roles in mouse early embryonic development during which Eras expression is negatively regulated by the β-catenin pathway. Thus, beyond its well-known role on cell proliferation, ERAS may also play important roles in cell lineage specification during mouse early embryonic development. |
| first_indexed | 2024-12-18T15:13:24Z |
| format | Article |
| id | doaj.art-a8ee5b5e98824de08e22445d8a951f31 |
| institution | Directory Open Access Journal |
| issn | 2046-2441 |
| language | English |
| last_indexed | 2024-12-18T15:13:24Z |
| publishDate | 2015-01-01 |
| publisher | The Royal Society |
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| series | Open Biology |
| spelling | doaj.art-a8ee5b5e98824de08e22445d8a951f312022-12-21T21:03:35ZengThe Royal SocietyOpen Biology2046-24412015-01-015810.1098/rsob.150092150092The roles of ERAS during cell lineage specification of mouse early embryonic developmentZhen-Ao ZhaoYang YuHuai-Xiao MaXiao-Xiao WangXukun LuYanhua ZhaiXiaoxin ZhangHaibin WangLei LiEras encodes a Ras-like GTPase protein that was originally identified as an embryonic stem cell-specific Ras. ERAS has been known to be required for the growth of embryonic stem cells and stimulates somatic cell reprogramming, suggesting its roles on mouse early embryonic development. We now report a dynamic expression pattern of Eras during mouse peri-implantation development: its expression increases at the blastocyst stage, and specifically decreases in E7.5 mesoderm. In accordance with its expression pattern, the increased expression of Eras promotes cell proliferation through controlling AKT activation and the commitment from ground to primed state through ERK activation in mouse embryonic stem cells; and the reduced expression of Eras facilitates primitive streak and mesoderm formation through AKT inhibition during gastrulation. The expression of Eras is finely regulated to match its roles in mouse early embryonic development during which Eras expression is negatively regulated by the β-catenin pathway. Thus, beyond its well-known role on cell proliferation, ERAS may also play important roles in cell lineage specification during mouse early embryonic development.https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.150092erasprimitive streakmesodermembryonic stem cellscell lineage |
| spellingShingle | Zhen-Ao Zhao Yang Yu Huai-Xiao Ma Xiao-Xiao Wang Xukun Lu Yanhua Zhai Xiaoxin Zhang Haibin Wang Lei Li The roles of ERAS during cell lineage specification of mouse early embryonic development Open Biology eras primitive streak mesoderm embryonic stem cells cell lineage |
| title | The roles of ERAS during cell lineage specification of mouse early embryonic development |
| title_full | The roles of ERAS during cell lineage specification of mouse early embryonic development |
| title_fullStr | The roles of ERAS during cell lineage specification of mouse early embryonic development |
| title_full_unstemmed | The roles of ERAS during cell lineage specification of mouse early embryonic development |
| title_short | The roles of ERAS during cell lineage specification of mouse early embryonic development |
| title_sort | roles of eras during cell lineage specification of mouse early embryonic development |
| topic | eras primitive streak mesoderm embryonic stem cells cell lineage |
| url | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.150092 |
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