Unconscious mind activates central cardiovascular network and promotes adaptation to microgravity possibly anti-aging during 1-year-long spaceflight
Abstract The intrinsic cardiovascular regulatory system (β, 0.00013–0.02 Hz) did not adapt to microgravity after a 6-month spaceflight. The infraslow oscillation (ISO, 0.01–0.10 Hz) coordinating brain dynamics via thalamic astrocytes plays a key role in the adaptation to novel environments. We inves...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-14858-8 |
| _version_ | 1818197608483520512 |
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| author | Kuniaki Otsuka Germaine Cornelissen Satoshi Furukawa Koichi Shibata Yutaka Kubo Koh Mizuno Tatsuya Aiba Hiroshi Ohshima Chiaki Mukai |
| author_facet | Kuniaki Otsuka Germaine Cornelissen Satoshi Furukawa Koichi Shibata Yutaka Kubo Koh Mizuno Tatsuya Aiba Hiroshi Ohshima Chiaki Mukai |
| author_sort | Kuniaki Otsuka |
| collection | DOAJ |
| description | Abstract The intrinsic cardiovascular regulatory system (β, 0.00013–0.02 Hz) did not adapt to microgravity after a 6-month spaceflight. The infraslow oscillation (ISO, 0.01–0.10 Hz) coordinating brain dynamics via thalamic astrocytes plays a key role in the adaptation to novel environments. We investigate the adaptive process of a healthy astronaut during a 12-month-long spaceflight by analyzing heart rate variability (HRV) in the LF (0.01–0.05 Hz) and MF1 (0.05–0.10 Hz) bands for two consecutive days on four occasions: before launch, at 1-month (ISS01) and 11-month (ISS02) in space, and after return to Earth. Alteration of β during ISS01 improved during ISS02 (P = 0.0167). During ISS01, LF and MF1 bands, reflecting default mode network (DMN) activity, started to increase at night (by 43.1% and 32.0%, respectively), when suprachiasmatic astrocytes are most active, followed by a 25.9% increase in MF1-band throughout the entire day during ISS02, larger at night (47.4%) than during daytime. Magnetic declination correlated positively with β during ISS01 (r = 0.6706, P < 0.0001) and ISS02 (r = 0.3958, P = 0.0095). Magnetic fluctuations may affect suprachiasmatic astrocytes, and the DMN involving ISOs and thalamic astrocytes may then be activated, first at night, then during the entire day, a mechanism that could perhaps promote an anti-aging effect noted in other investigations. |
| first_indexed | 2024-12-12T01:52:41Z |
| format | Article |
| id | doaj.art-a8f52716d90e44919c2eb26e95a0ddbf |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-12T01:52:41Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-a8f52716d90e44919c2eb26e95a0ddbf2022-12-22T00:42:27ZengNature PortfolioScientific Reports2045-23222022-07-0112111310.1038/s41598-022-14858-8Unconscious mind activates central cardiovascular network and promotes adaptation to microgravity possibly anti-aging during 1-year-long spaceflightKuniaki Otsuka0Germaine Cornelissen1Satoshi Furukawa2Koichi Shibata3Yutaka Kubo4Koh Mizuno5Tatsuya Aiba6Hiroshi Ohshima7Chiaki Mukai8Executive Medical Center, Related Medical Facility, Totsuka Royal Clinic, Tokyo Women’s Medical University, Sinjuku CityHalberg Chronobiology Center, University of MinnesotaSpace Biomedical Research Group, Japan Aerospace Exploration AgencyDepartment of Medicine, Medical Center East, Tokyo Women’s Medical UniversityDepartment of Medicine, Medical Center East, Tokyo Women’s Medical UniversitySpace Biomedical Research Group, Japan Aerospace Exploration AgencySpace Biomedical Research Group, Japan Aerospace Exploration AgencySpace Biomedical Research Group, Japan Aerospace Exploration AgencySpace Biomedical Research Group, Japan Aerospace Exploration AgencyAbstract The intrinsic cardiovascular regulatory system (β, 0.00013–0.02 Hz) did not adapt to microgravity after a 6-month spaceflight. The infraslow oscillation (ISO, 0.01–0.10 Hz) coordinating brain dynamics via thalamic astrocytes plays a key role in the adaptation to novel environments. We investigate the adaptive process of a healthy astronaut during a 12-month-long spaceflight by analyzing heart rate variability (HRV) in the LF (0.01–0.05 Hz) and MF1 (0.05–0.10 Hz) bands for two consecutive days on four occasions: before launch, at 1-month (ISS01) and 11-month (ISS02) in space, and after return to Earth. Alteration of β during ISS01 improved during ISS02 (P = 0.0167). During ISS01, LF and MF1 bands, reflecting default mode network (DMN) activity, started to increase at night (by 43.1% and 32.0%, respectively), when suprachiasmatic astrocytes are most active, followed by a 25.9% increase in MF1-band throughout the entire day during ISS02, larger at night (47.4%) than during daytime. Magnetic declination correlated positively with β during ISS01 (r = 0.6706, P < 0.0001) and ISS02 (r = 0.3958, P = 0.0095). Magnetic fluctuations may affect suprachiasmatic astrocytes, and the DMN involving ISOs and thalamic astrocytes may then be activated, first at night, then during the entire day, a mechanism that could perhaps promote an anti-aging effect noted in other investigations.https://doi.org/10.1038/s41598-022-14858-8 |
| spellingShingle | Kuniaki Otsuka Germaine Cornelissen Satoshi Furukawa Koichi Shibata Yutaka Kubo Koh Mizuno Tatsuya Aiba Hiroshi Ohshima Chiaki Mukai Unconscious mind activates central cardiovascular network and promotes adaptation to microgravity possibly anti-aging during 1-year-long spaceflight Scientific Reports |
| title | Unconscious mind activates central cardiovascular network and promotes adaptation to microgravity possibly anti-aging during 1-year-long spaceflight |
| title_full | Unconscious mind activates central cardiovascular network and promotes adaptation to microgravity possibly anti-aging during 1-year-long spaceflight |
| title_fullStr | Unconscious mind activates central cardiovascular network and promotes adaptation to microgravity possibly anti-aging during 1-year-long spaceflight |
| title_full_unstemmed | Unconscious mind activates central cardiovascular network and promotes adaptation to microgravity possibly anti-aging during 1-year-long spaceflight |
| title_short | Unconscious mind activates central cardiovascular network and promotes adaptation to microgravity possibly anti-aging during 1-year-long spaceflight |
| title_sort | unconscious mind activates central cardiovascular network and promotes adaptation to microgravity possibly anti aging during 1 year long spaceflight |
| url | https://doi.org/10.1038/s41598-022-14858-8 |
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