Mental health symptoms and illness trajectory following COVID-19 hospitalization: A cohort study
Background: The multisystem associations between baseline mental health status and coronavirus disease-19 (COVID)-19 illness trajectory are uncertain. Objectives: This article will investigate the associations between baseline mental health status and disease trajectory following COVID-19 hospitaliz...
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Heart and Mind |
| Subjects: | |
| Online Access: | http://www.heartmindjournal.org/article.asp?issn=2468-6476;year=2023;volume=7;issue=4;spage=235;epage=245;aulast=Lomholt-Welch |
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| author | Harriet Lomholt-Welch Andrew J Morrow Robert Sykes Merna Saleh Baryab Zahra Alasdair MacIntosh Anna Kamdar Catherine Bagot Hannah K Bayes Kevin G Blyth Heerajnarain Bulluck David Carrick Colin Church David Corcoran Iain Findlay Vivienne B Gibson Lynsey Gillespie Douglas Grieve Pauline Hall Barrientos Antonia Ho Ninian N Lang David J Lowe Vera Lennie Peter W Macfarlane Kaitlin J Mayne Patrick B Mark Alex McConnachie Ross McGeoch Sabrina Nordin Alexander Payne Alastair J Rankin Keith Robertson Nicola Ryan Giles Roditi Naveed Sattar David Stobo Sarah Allwood-Spiers Rhian M Touyz Gruschen Veldtman Sarah Weeden Robin Weir Stuart Watkins Paul Welsh Kenneth Mangion Colin Berry |
| author_facet | Harriet Lomholt-Welch Andrew J Morrow Robert Sykes Merna Saleh Baryab Zahra Alasdair MacIntosh Anna Kamdar Catherine Bagot Hannah K Bayes Kevin G Blyth Heerajnarain Bulluck David Carrick Colin Church David Corcoran Iain Findlay Vivienne B Gibson Lynsey Gillespie Douglas Grieve Pauline Hall Barrientos Antonia Ho Ninian N Lang David J Lowe Vera Lennie Peter W Macfarlane Kaitlin J Mayne Patrick B Mark Alex McConnachie Ross McGeoch Sabrina Nordin Alexander Payne Alastair J Rankin Keith Robertson Nicola Ryan Giles Roditi Naveed Sattar David Stobo Sarah Allwood-Spiers Rhian M Touyz Gruschen Veldtman Sarah Weeden Robin Weir Stuart Watkins Paul Welsh Kenneth Mangion Colin Berry |
| author_sort | Harriet Lomholt-Welch |
| collection | DOAJ |
| description | Background: The multisystem associations between baseline mental health status and coronavirus disease-19 (COVID)-19 illness trajectory are uncertain. Objectives: This article will investigate the associations between baseline mental health status and disease trajectory following COVID-19 hospitalization, which may have implications for practice and future research. Methods: The Chief Scientist Office Cardiovascular and Pulmonary Imaging in severe acute respiratory syndrome (SARS) COVID-19 study is a prospective, observational, multicenter, longitudinal, secondary care cohort study that assessed the time-course of multi-organ injury in posthospital survivors of COVID-19. Patients were assessed in-hospital, at 28–60 days after discharge and in the longer term using electronic health record linkage. Results: One hundred and fifty-two patients (mean ± standard deviation [SD] age 54.3 ± 11.8 years, 43% female, 40% most socio-economically deprived quintile, 33% history of mental health history) were enrolled and had mental health serially assessed using the Patient Health Questionnaire-4 (PHQ-4) questionnaire. Fifty-three (35%) had PHQ-4 score of 6–12 consistent with moderate-severe symptoms of anxiety or depression and this was associated with diagnostic criteria for myocarditis (P = 0.0498). Moderate-severe symptoms of anxiety or depression were positively associated with higher perception of illness, lower health-related quality of life (HRQoL), and poorer physical function. The mean (SD) duration of follow-up after hospital discharge was 428 (86) days (range, 290–627 days). PHQ-4 score was not associated with clinical outcomes at follow-up. Conclusions: In patients who have been hospitalized with COVID-19, moderate-severe symptoms of anxiety or depression were associated with myocarditis, worse HRQoL, higher perception of illness, and lower levels of physical function. Public Registration: ClinicalTrials.gov identifier is NCT04403607. |
| first_indexed | 2024-03-08T13:11:32Z |
| format | Article |
| id | doaj.art-a8f576cb386f4ef2b6e1475b9b83287b |
| institution | Directory Open Access Journal |
| issn | 2468-6476 2468-6484 |
| language | English |
| last_indexed | 2025-03-22T05:15:28Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Heart and Mind |
| spelling | doaj.art-a8f576cb386f4ef2b6e1475b9b83287b2024-04-27T05:29:54ZengWolters Kluwer Medknow PublicationsHeart and Mind2468-64762468-64842023-01-017423524510.4103/hm.HM-D-23-00037Mental health symptoms and illness trajectory following COVID-19 hospitalization: A cohort studyHarriet Lomholt-WelchAndrew J MorrowRobert SykesMerna SalehBaryab ZahraAlasdair MacIntoshAnna KamdarCatherine BagotHannah K BayesKevin G BlythHeerajnarain BulluckDavid CarrickColin ChurchDavid CorcoranIain FindlayVivienne B GibsonLynsey GillespieDouglas GrievePauline Hall BarrientosAntonia HoNinian N LangDavid J LoweVera LenniePeter W MacfarlaneKaitlin J MaynePatrick B MarkAlex McConnachieRoss McGeochSabrina NordinAlexander PayneAlastair J RankinKeith RobertsonNicola RyanGiles RoditiNaveed SattarDavid StoboSarah Allwood-SpiersRhian M TouyzGruschen VeldtmanSarah WeedenRobin WeirStuart WatkinsPaul WelshKenneth MangionColin BerryBackground: The multisystem associations between baseline mental health status and coronavirus disease-19 (COVID)-19 illness trajectory are uncertain. Objectives: This article will investigate the associations between baseline mental health status and disease trajectory following COVID-19 hospitalization, which may have implications for practice and future research. Methods: The Chief Scientist Office Cardiovascular and Pulmonary Imaging in severe acute respiratory syndrome (SARS) COVID-19 study is a prospective, observational, multicenter, longitudinal, secondary care cohort study that assessed the time-course of multi-organ injury in posthospital survivors of COVID-19. Patients were assessed in-hospital, at 28–60 days after discharge and in the longer term using electronic health record linkage. Results: One hundred and fifty-two patients (mean ± standard deviation [SD] age 54.3 ± 11.8 years, 43% female, 40% most socio-economically deprived quintile, 33% history of mental health history) were enrolled and had mental health serially assessed using the Patient Health Questionnaire-4 (PHQ-4) questionnaire. Fifty-three (35%) had PHQ-4 score of 6–12 consistent with moderate-severe symptoms of anxiety or depression and this was associated with diagnostic criteria for myocarditis (P = 0.0498). Moderate-severe symptoms of anxiety or depression were positively associated with higher perception of illness, lower health-related quality of life (HRQoL), and poorer physical function. The mean (SD) duration of follow-up after hospital discharge was 428 (86) days (range, 290–627 days). PHQ-4 score was not associated with clinical outcomes at follow-up. Conclusions: In patients who have been hospitalized with COVID-19, moderate-severe symptoms of anxiety or depression were associated with myocarditis, worse HRQoL, higher perception of illness, and lower levels of physical function. Public Registration: ClinicalTrials.gov identifier is NCT04403607.http://www.heartmindjournal.org/article.asp?issn=2468-6476;year=2023;volume=7;issue=4;spage=235;epage=245;aulast=Lomholt-Welchlong coronavirus disease-19mental healthpost-coronavirus disease-19 conditionsevere acute respiratory syndrome-coronavirus-2 |
| spellingShingle | Harriet Lomholt-Welch Andrew J Morrow Robert Sykes Merna Saleh Baryab Zahra Alasdair MacIntosh Anna Kamdar Catherine Bagot Hannah K Bayes Kevin G Blyth Heerajnarain Bulluck David Carrick Colin Church David Corcoran Iain Findlay Vivienne B Gibson Lynsey Gillespie Douglas Grieve Pauline Hall Barrientos Antonia Ho Ninian N Lang David J Lowe Vera Lennie Peter W Macfarlane Kaitlin J Mayne Patrick B Mark Alex McConnachie Ross McGeoch Sabrina Nordin Alexander Payne Alastair J Rankin Keith Robertson Nicola Ryan Giles Roditi Naveed Sattar David Stobo Sarah Allwood-Spiers Rhian M Touyz Gruschen Veldtman Sarah Weeden Robin Weir Stuart Watkins Paul Welsh Kenneth Mangion Colin Berry Mental health symptoms and illness trajectory following COVID-19 hospitalization: A cohort study Heart and Mind long coronavirus disease-19 mental health post-coronavirus disease-19 condition severe acute respiratory syndrome-coronavirus-2 |
| title | Mental health symptoms and illness trajectory following COVID-19 hospitalization: A cohort study |
| title_full | Mental health symptoms and illness trajectory following COVID-19 hospitalization: A cohort study |
| title_fullStr | Mental health symptoms and illness trajectory following COVID-19 hospitalization: A cohort study |
| title_full_unstemmed | Mental health symptoms and illness trajectory following COVID-19 hospitalization: A cohort study |
| title_short | Mental health symptoms and illness trajectory following COVID-19 hospitalization: A cohort study |
| title_sort | mental health symptoms and illness trajectory following covid 19 hospitalization a cohort study |
| topic | long coronavirus disease-19 mental health post-coronavirus disease-19 condition severe acute respiratory syndrome-coronavirus-2 |
| url | http://www.heartmindjournal.org/article.asp?issn=2468-6476;year=2023;volume=7;issue=4;spage=235;epage=245;aulast=Lomholt-Welch |
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