Single-cell transcriptome profiling of sepsis identifies HLA-DR low S100A high monocytes with immunosuppressive function

Single-cell transcriptome profiling of sepsis identifies HLA-DR low S100A high monocytes with immunosuppressive function

Abstract Background Sustained yet intractable immunosuppression is commonly observed in septic patients, resulting in aggravated clinical outcomes. However, due to the substantial heterogeneity within septic patients, precise indicators in deciphering clinical trajectories and immunological alterati...

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Main Authors: Ren-Qi Yao, Peng-Yue Zhao, Zhi-Xuan Li, Yu-Yang Liu, Li-Yu Zheng, Yu Duan, Lu Wang, Rong-Li Yang, Hong-Jun Kang, Ji-Wei Hao, Jing-Yan Li, Ning Dong, Yao Wu, Xiao-Hui Du, Feng Zhu, Chao Ren, Guo-Sheng Wu, Zhao-Fan Xia, Yong-Ming Yao
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Military Medical Research
Subjects:
Single-cell analysis
Sepsis
Immunosuppression
S100A
Human leukocyte antigen DR (HLA-DR)
Monocytes
Online Access:https://doi.org/10.1186/s40779-023-00462-y

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