Vitamin K-dependent proteins: osteocalcin, matrix Gla-protein and extra osseous effects
Vitamin K - is a fat-soluble vitamin which plays an important role in the metabolism of bone and connective tissue, maintenance blood clotting properties. Vitamin K is involved in carboxylation of glutamic acid residues in the polypeptide chains of 14 human proteins, providing them with the necessar...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Endocrinology Research Centre
2013-06-01
|
| Series: | Ожирение и метаболизм |
| Subjects: | |
| Online Access: | https://www.omet-endojournals.ru/jour/article/view/4818 |
| Summary: | Vitamin K - is a fat-soluble vitamin which plays an important role in the metabolism of bone and connective tissue, maintenance blood clotting properties. Vitamin K is involved in carboxylation of glutamic acid residues in the polypeptide chains of 14 human proteins, providing them with the necessary functional properties. Lack of vitamin K-dependent carboxylation of these proteins leads to changes in their biological activity. In this literature review we cover the mechanisms of vitamin K-dependent carboxylation and none bone actions of osteocalcin and matrix Gla-protein with different degrees of carboxylation. |
|---|---|
| ISSN: | 2071-8713 2306-5524 |