Vitamin K-dependent proteins: osteocalcin, matrix Gla-protein and extra osseous effects
Vitamin K - is a fat-soluble vitamin which plays an important role in the metabolism of bone and connective tissue, maintenance blood clotting properties. Vitamin K is involved in carboxylation of glutamic acid residues in the polypeptide chains of 14 human proteins, providing them with the necessar...
| Κύριοι συγγραφείς: | , , |
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| Μορφή: | Άρθρο |
| Γλώσσα: | English |
| Έκδοση: |
Endocrinology Research Centre
2013-06-01
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| Σειρά: | Ожирение и метаболизм |
| Θέματα: | |
| Διαθέσιμο Online: | https://www.omet-endojournals.ru/jour/article/view/4818 |
| _version_ | 1827121790314348544 |
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| author | Yu В Pankratova E A Pigarova L K Dzeranova |
| author_facet | Yu В Pankratova E A Pigarova L K Dzeranova |
| author_sort | Yu В Pankratova |
| collection | DOAJ |
| description | Vitamin K - is a fat-soluble vitamin which plays an important role in the metabolism of bone and connective tissue, maintenance blood clotting properties. Vitamin K is involved in carboxylation of glutamic acid residues in the polypeptide chains of 14 human proteins, providing them with the necessary functional properties. Lack of vitamin K-dependent carboxylation of these proteins leads to changes in their biological activity. In this literature review we cover the mechanisms of vitamin K-dependent carboxylation and none bone actions of osteocalcin and matrix Gla-protein with different degrees of carboxylation. |
| first_indexed | 2024-03-08T09:14:27Z |
| format | Article |
| id | doaj.art-a8f9e84b806e458fb97414f15356f678 |
| institution | Directory Open Access Journal |
| issn | 2071-8713 2306-5524 |
| language | English |
| last_indexed | 2025-03-20T13:58:44Z |
| publishDate | 2013-06-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Ожирение и метаболизм |
| spelling | doaj.art-a8f9e84b806e458fb97414f15356f6782024-09-11T16:17:48ZengEndocrinology Research CentreОжирение и метаболизм2071-87132306-55242013-06-01102111810.14341/2071-8713-48184776Vitamin K-dependent proteins: osteocalcin, matrix Gla-protein and extra osseous effectsYu В PankratovaE A PigarovaL K DzeranovaVitamin K - is a fat-soluble vitamin which plays an important role in the metabolism of bone and connective tissue, maintenance blood clotting properties. Vitamin K is involved in carboxylation of glutamic acid residues in the polypeptide chains of 14 human proteins, providing them with the necessary functional properties. Lack of vitamin K-dependent carboxylation of these proteins leads to changes in their biological activity. In this literature review we cover the mechanisms of vitamin K-dependent carboxylation and none bone actions of osteocalcin and matrix Gla-protein with different degrees of carboxylation.https://www.omet-endojournals.ru/jour/article/view/4818vitamin kcarboxylationosteocalcinmatrix gla-proteindiabetes mellitusimpaired glucose tolerancevascular calcification |
| spellingShingle | Yu В Pankratova E A Pigarova L K Dzeranova Vitamin K-dependent proteins: osteocalcin, matrix Gla-protein and extra osseous effects Ожирение и метаболизм vitamin k carboxylation osteocalcin matrix gla-protein diabetes mellitus impaired glucose tolerance vascular calcification |
| title | Vitamin K-dependent proteins: osteocalcin, matrix Gla-protein and extra osseous effects |
| title_full | Vitamin K-dependent proteins: osteocalcin, matrix Gla-protein and extra osseous effects |
| title_fullStr | Vitamin K-dependent proteins: osteocalcin, matrix Gla-protein and extra osseous effects |
| title_full_unstemmed | Vitamin K-dependent proteins: osteocalcin, matrix Gla-protein and extra osseous effects |
| title_short | Vitamin K-dependent proteins: osteocalcin, matrix Gla-protein and extra osseous effects |
| title_sort | vitamin k dependent proteins osteocalcin matrix gla protein and extra osseous effects |
| topic | vitamin k carboxylation osteocalcin matrix gla-protein diabetes mellitus impaired glucose tolerance vascular calcification |
| url | https://www.omet-endojournals.ru/jour/article/view/4818 |
| work_keys_str_mv | AT yuvpankratova vitaminkdependentproteinsosteocalcinmatrixglaproteinandextraosseouseffects AT eapigarova vitaminkdependentproteinsosteocalcinmatrixglaproteinandextraosseouseffects AT lkdzeranova vitaminkdependentproteinsosteocalcinmatrixglaproteinandextraosseouseffects |