Network-level connectivity dynamics of movie watching in 6-year-old children
Better understanding of the developing brain’s functional mechanisms is critical for improving diagnosis and treatment of different developmental disorders. Particularly, characterizing how the developing brain dynamically reorganizes during different cognitive states may offer novel insight into t...
| Κύριοι συγγραφείς: | , , , , |
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| Μορφή: | Άρθρο |
| Γλώσσα: | English |
| Έκδοση: |
Frontiers Media S.A.
2015-11-01
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| Σειρά: | Frontiers in Human Neuroscience |
| Θέματα: | |
| Διαθέσιμο Online: | http://journal.frontiersin.org/Journal/10.3389/fnhum.2015.00631/full |
| _version_ | 1828462135465738240 |
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| author | Robert W Emerson Robert W Emerson Sarah J. Short Weili eLin John H. Gilmore Wei eGao Wei eGao |
| author_facet | Robert W Emerson Robert W Emerson Sarah J. Short Weili eLin John H. Gilmore Wei eGao Wei eGao |
| author_sort | Robert W Emerson |
| collection | DOAJ |
| description | Better understanding of the developing brain’s functional mechanisms is critical for improving diagnosis and treatment of different developmental disorders. Particularly, characterizing how the developing brain dynamically reorganizes during different cognitive states may offer novel insight into the neuronal mechanisms of cognitive deficits. Imaging the brain during naturalistic conditions, like movie watching, provides a highly practical way to study young children’s developing functional brain systems. In this study we compared the network-level functional organization of 6-year-old children while they were at rest with their functional connectivity as they watched short video clips. We employed both a data-driven independent component analysis (ICA) approach and a hypothesis-driven seed-based analysis to identify changes in network-level functional interactions during the shift from resting to video watching. Our ICA results showed that naturally watching a movie elicits significant changes in the functional connectivity between the visual system and the dorsal attention network when compared to rest (t(32) =5.02, p<.0001). More interestingly, children showed an immature, but qualitatively adult-like, pattern of reorganization among three of the brain’s higher-order networks (frontal control, default-mode and dorsal attention). For both ICA and seed-based approaches, we observed a decrease in the frontal network’s correlation with the dorsal attention network (ICA: t(32) =-2.46, p=.02; Seed-based: t(32) =-1.62, p=.12) and an increase in its connectivity with the default mode network (ICA: t(32) =2.84, p=.008; Seed-based: t(32) =2.28, p=.03), which is highly consistent with the pattern observed in adults. These results offer improved understanding of the developing brain’s dynamic network-level interaction patterns during the transition between different brain states and call for further studies to examine potential alterations to such dynamic patterns in different developmental disorders. |
| first_indexed | 2024-12-11T02:32:40Z |
| format | Article |
| id | doaj.art-a8f9ffb057ae4a8dbc7e25e7aa6d3598 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-11T02:32:40Z |
| publishDate | 2015-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-a8f9ffb057ae4a8dbc7e25e7aa6d35982022-12-22T01:23:49ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612015-11-01910.3389/fnhum.2015.00631159962Network-level connectivity dynamics of movie watching in 6-year-old childrenRobert W Emerson0Robert W Emerson1Sarah J. Short2Weili eLin3John H. Gilmore4Wei eGao5Wei eGao6UNC Chapel HillUNC Chapel HillUNC Chapel HillUNC Chapel HillUNC Chapel HillUNC Chapel HillCedars-Sinai Medical CenterBetter understanding of the developing brain’s functional mechanisms is critical for improving diagnosis and treatment of different developmental disorders. Particularly, characterizing how the developing brain dynamically reorganizes during different cognitive states may offer novel insight into the neuronal mechanisms of cognitive deficits. Imaging the brain during naturalistic conditions, like movie watching, provides a highly practical way to study young children’s developing functional brain systems. In this study we compared the network-level functional organization of 6-year-old children while they were at rest with their functional connectivity as they watched short video clips. We employed both a data-driven independent component analysis (ICA) approach and a hypothesis-driven seed-based analysis to identify changes in network-level functional interactions during the shift from resting to video watching. Our ICA results showed that naturally watching a movie elicits significant changes in the functional connectivity between the visual system and the dorsal attention network when compared to rest (t(32) =5.02, p<.0001). More interestingly, children showed an immature, but qualitatively adult-like, pattern of reorganization among three of the brain’s higher-order networks (frontal control, default-mode and dorsal attention). For both ICA and seed-based approaches, we observed a decrease in the frontal network’s correlation with the dorsal attention network (ICA: t(32) =-2.46, p=.02; Seed-based: t(32) =-1.62, p=.12) and an increase in its connectivity with the default mode network (ICA: t(32) =2.84, p=.008; Seed-based: t(32) =2.28, p=.03), which is highly consistent with the pattern observed in adults. These results offer improved understanding of the developing brain’s dynamic network-level interaction patterns during the transition between different brain states and call for further studies to examine potential alterations to such dynamic patterns in different developmental disorders.http://journal.frontiersin.org/Journal/10.3389/fnhum.2015.00631/fullDevelopmental Cognitive NeuroscienceFunctional network of the brainresting state functional connectivityyoung childrennaturalistic stimuli |
| spellingShingle | Robert W Emerson Robert W Emerson Sarah J. Short Weili eLin John H. Gilmore Wei eGao Wei eGao Network-level connectivity dynamics of movie watching in 6-year-old children Frontiers in Human Neuroscience Developmental Cognitive Neuroscience Functional network of the brain resting state functional connectivity young children naturalistic stimuli |
| title | Network-level connectivity dynamics of movie watching in 6-year-old children |
| title_full | Network-level connectivity dynamics of movie watching in 6-year-old children |
| title_fullStr | Network-level connectivity dynamics of movie watching in 6-year-old children |
| title_full_unstemmed | Network-level connectivity dynamics of movie watching in 6-year-old children |
| title_short | Network-level connectivity dynamics of movie watching in 6-year-old children |
| title_sort | network level connectivity dynamics of movie watching in 6 year old children |
| topic | Developmental Cognitive Neuroscience Functional network of the brain resting state functional connectivity young children naturalistic stimuli |
| url | http://journal.frontiersin.org/Journal/10.3389/fnhum.2015.00631/full |
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