Beneficial Role of <i>Carica papaya</i> Extracts and Phytochemicals on Oxidative Stress and Related Diseases: A Mini Review
Oxidative stress is a result of disruption in the balance between antioxidants and pro-oxidants in which subsequently impacting on redox signaling, causing cell and tissue damages. It leads to a range of medical conditions including inflammation, skin aging, impaired wound healing, chronic diseases...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/10/4/287 |
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| author | Yew Rong Kong Yong Xin Jong Manisha Balakrishnan Zhui Ken Bok Janice Kwan Kah Weng Kai Ching Tay Bey Hing Goh Yong Sze Ong Kok Gan Chan Learn Han Lee Kooi Yeong Khaw |
| author_facet | Yew Rong Kong Yong Xin Jong Manisha Balakrishnan Zhui Ken Bok Janice Kwan Kah Weng Kai Ching Tay Bey Hing Goh Yong Sze Ong Kok Gan Chan Learn Han Lee Kooi Yeong Khaw |
| author_sort | Yew Rong Kong |
| collection | DOAJ |
| description | Oxidative stress is a result of disruption in the balance between antioxidants and pro-oxidants in which subsequently impacting on redox signaling, causing cell and tissue damages. It leads to a range of medical conditions including inflammation, skin aging, impaired wound healing, chronic diseases and cancers but these conditions can be managed properly with the aid of antioxidants. This review features various studies to provide an overview on how <i>Carica papaya</i> help counteract oxidative stress via various mechanisms of action closely related to its antioxidant properties and eventually improving the management of various oxidative stress-related health conditions. <i>Carica papaya</i> is a topical plant species discovered to contain high amounts of natural antioxidants that can usually be found in their leaves, fruits and seeds. It contains various chemical compounds demonstrate significant antioxidant properties including caffeic acid, myricetin, rutin, quercetin, α-tocopherol, papain, benzyl isothiocyanate (BiTC), and kaempferol. Therefore, it can counteract pro-oxidants via a number of signaling pathways that either promote the expression of antioxidant enzymes or reduce ROS production. These signaling pathways activate the antioxidant defense mechanisms that protect the body against both intrinsic and extrinsic oxidative stress. To conclude, <i>Carica papaya</i> can be incorporated into medications or supplements to help manage the health conditions driven by oxidative stress and further studies are needed to investigate the potential of its chemical components to manage various chronic diseases. |
| first_indexed | 2024-03-10T12:41:50Z |
| format | Article |
| id | doaj.art-a8fc39cdc3d342e0a8c3b8e6b65b8a5f |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-10T12:41:50Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-a8fc39cdc3d342e0a8c3b8e6b65b8a5f2023-11-21T13:50:41ZengMDPI AGBiology2079-77372021-04-0110428710.3390/biology10040287Beneficial Role of <i>Carica papaya</i> Extracts and Phytochemicals on Oxidative Stress and Related Diseases: A Mini ReviewYew Rong Kong0Yong Xin Jong1Manisha Balakrishnan2Zhui Ken Bok3Janice Kwan Kah Weng4Kai Ching Tay5Bey Hing Goh6Yong Sze Ong7Kok Gan Chan8Learn Han Lee9Kooi Yeong Khaw10Biofunctional Molecule Exploratory Research Group (BMEX), School of Pharmacy, Monash University Malaysia, Bandar Sunway 47500, MalaysiaBiofunctional Molecule Exploratory Research Group (BMEX), School of Pharmacy, Monash University Malaysia, Bandar Sunway 47500, MalaysiaBiofunctional Molecule Exploratory Research Group (BMEX), School of Pharmacy, Monash University Malaysia, Bandar Sunway 47500, MalaysiaBiofunctional Molecule Exploratory Research Group (BMEX), School of Pharmacy, Monash University Malaysia, Bandar Sunway 47500, MalaysiaBiofunctional Molecule Exploratory Research Group (BMEX), School of Pharmacy, Monash University Malaysia, Bandar Sunway 47500, MalaysiaBiofunctional Molecule Exploratory Research Group (BMEX), School of Pharmacy, Monash University Malaysia, Bandar Sunway 47500, MalaysiaBiofunctional Molecule Exploratory Research Group (BMEX), School of Pharmacy, Monash University Malaysia, Bandar Sunway 47500, MalaysiaBiofunctional Molecule Exploratory Research Group (BMEX), School of Pharmacy, Monash University Malaysia, Bandar Sunway 47500, MalaysiaDivision of Genetics and Molecular Biology, Faculty of Science, Institute of Biological Sciences, University of Malaya, Kuala Lumpur 50603, MalaysiaNovel Bacteria and Drug Discovery Research Group (NBDD), Microbiome and Bioresource Research Strength (MBRS), Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway 47500, MalaysiaBiofunctional Molecule Exploratory Research Group (BMEX), School of Pharmacy, Monash University Malaysia, Bandar Sunway 47500, MalaysiaOxidative stress is a result of disruption in the balance between antioxidants and pro-oxidants in which subsequently impacting on redox signaling, causing cell and tissue damages. It leads to a range of medical conditions including inflammation, skin aging, impaired wound healing, chronic diseases and cancers but these conditions can be managed properly with the aid of antioxidants. This review features various studies to provide an overview on how <i>Carica papaya</i> help counteract oxidative stress via various mechanisms of action closely related to its antioxidant properties and eventually improving the management of various oxidative stress-related health conditions. <i>Carica papaya</i> is a topical plant species discovered to contain high amounts of natural antioxidants that can usually be found in their leaves, fruits and seeds. It contains various chemical compounds demonstrate significant antioxidant properties including caffeic acid, myricetin, rutin, quercetin, α-tocopherol, papain, benzyl isothiocyanate (BiTC), and kaempferol. Therefore, it can counteract pro-oxidants via a number of signaling pathways that either promote the expression of antioxidant enzymes or reduce ROS production. These signaling pathways activate the antioxidant defense mechanisms that protect the body against both intrinsic and extrinsic oxidative stress. To conclude, <i>Carica papaya</i> can be incorporated into medications or supplements to help manage the health conditions driven by oxidative stress and further studies are needed to investigate the potential of its chemical components to manage various chronic diseases.https://www.mdpi.com/2079-7737/10/4/287oxidative stressantioxidant<i>Carica papaya</i>inflammationdiabetescancer |
| spellingShingle | Yew Rong Kong Yong Xin Jong Manisha Balakrishnan Zhui Ken Bok Janice Kwan Kah Weng Kai Ching Tay Bey Hing Goh Yong Sze Ong Kok Gan Chan Learn Han Lee Kooi Yeong Khaw Beneficial Role of <i>Carica papaya</i> Extracts and Phytochemicals on Oxidative Stress and Related Diseases: A Mini Review Biology oxidative stress antioxidant <i>Carica papaya</i> inflammation diabetes cancer |
| title | Beneficial Role of <i>Carica papaya</i> Extracts and Phytochemicals on Oxidative Stress and Related Diseases: A Mini Review |
| title_full | Beneficial Role of <i>Carica papaya</i> Extracts and Phytochemicals on Oxidative Stress and Related Diseases: A Mini Review |
| title_fullStr | Beneficial Role of <i>Carica papaya</i> Extracts and Phytochemicals on Oxidative Stress and Related Diseases: A Mini Review |
| title_full_unstemmed | Beneficial Role of <i>Carica papaya</i> Extracts and Phytochemicals on Oxidative Stress and Related Diseases: A Mini Review |
| title_short | Beneficial Role of <i>Carica papaya</i> Extracts and Phytochemicals on Oxidative Stress and Related Diseases: A Mini Review |
| title_sort | beneficial role of i carica papaya i extracts and phytochemicals on oxidative stress and related diseases a mini review |
| topic | oxidative stress antioxidant <i>Carica papaya</i> inflammation diabetes cancer |
| url | https://www.mdpi.com/2079-7737/10/4/287 |
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