No-Go Decay mRNA cleavage in the ribosome exit tunnel produces 5′-OH ends phosphorylated by Trl1
In the No-Go decay mRNA surveillance pathway, mRNAs containing stalled ribosomes are cleaved by an endoribonuclease. Here the authors show the endonucleolytic cleavage on the artificial No-Go decay target mRNAs, revealing downstream decay process by Trl1 kinase and the 5′ to 3′ exonuclease Dxo1.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13991-9 |
| _version_ | 1818342341415534592 |
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| author | Albertas Navickas Sébastien Chamois Rénette Saint-Fort Julien Henri Claire Torchet Lionel Benard |
| author_facet | Albertas Navickas Sébastien Chamois Rénette Saint-Fort Julien Henri Claire Torchet Lionel Benard |
| author_sort | Albertas Navickas |
| collection | DOAJ |
| description | In the No-Go decay mRNA surveillance pathway, mRNAs containing stalled ribosomes are cleaved by an endoribonuclease. Here the authors show the endonucleolytic cleavage on the artificial No-Go decay target mRNAs, revealing downstream decay process by Trl1 kinase and the 5′ to 3′ exonuclease Dxo1. |
| first_indexed | 2024-12-13T16:13:09Z |
| format | Article |
| id | doaj.art-a8fd17d189c847329043a5bf30ab1d19 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:13:09Z |
| publishDate | 2020-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a8fd17d189c847329043a5bf30ab1d192022-12-21T23:38:53ZengNature PortfolioNature Communications2041-17232020-01-0111111110.1038/s41467-019-13991-9No-Go Decay mRNA cleavage in the ribosome exit tunnel produces 5′-OH ends phosphorylated by Trl1Albertas Navickas0Sébastien Chamois1Rénette Saint-Fort2Julien Henri3Claire Torchet4Lionel Benard5Institut de Biologie Physico-Chimique, UMR8226, CNRS, Sorbonne Université, Laboratoire de Biologie moléculaire et Cellulaire des EucaryotesInstitut de Biologie Physico-Chimique, UMR8226, CNRS, Sorbonne Université, Laboratoire de Biologie moléculaire et Cellulaire des EucaryotesInstitut de Biologie Physico-Chimique, UMR8226, CNRS, Sorbonne Université, Laboratoire de Biologie moléculaire et Cellulaire des EucaryotesInstitut de Biologie Physico-Chimique, UMR8226, CNRS, Sorbonne Université, Laboratoire de Biologie moléculaire et Cellulaire des EucaryotesInstitut de Biologie Physico-Chimique, UMR8226, CNRS, Sorbonne Université, Laboratoire de Biologie moléculaire et Cellulaire des EucaryotesInstitut de Biologie Physico-Chimique, UMR8226, CNRS, Sorbonne Université, Laboratoire de Biologie moléculaire et Cellulaire des EucaryotesIn the No-Go decay mRNA surveillance pathway, mRNAs containing stalled ribosomes are cleaved by an endoribonuclease. Here the authors show the endonucleolytic cleavage on the artificial No-Go decay target mRNAs, revealing downstream decay process by Trl1 kinase and the 5′ to 3′ exonuclease Dxo1.https://doi.org/10.1038/s41467-019-13991-9 |
| spellingShingle | Albertas Navickas Sébastien Chamois Rénette Saint-Fort Julien Henri Claire Torchet Lionel Benard No-Go Decay mRNA cleavage in the ribosome exit tunnel produces 5′-OH ends phosphorylated by Trl1 Nature Communications |
| title | No-Go Decay mRNA cleavage in the ribosome exit tunnel produces 5′-OH ends phosphorylated by Trl1 |
| title_full | No-Go Decay mRNA cleavage in the ribosome exit tunnel produces 5′-OH ends phosphorylated by Trl1 |
| title_fullStr | No-Go Decay mRNA cleavage in the ribosome exit tunnel produces 5′-OH ends phosphorylated by Trl1 |
| title_full_unstemmed | No-Go Decay mRNA cleavage in the ribosome exit tunnel produces 5′-OH ends phosphorylated by Trl1 |
| title_short | No-Go Decay mRNA cleavage in the ribosome exit tunnel produces 5′-OH ends phosphorylated by Trl1 |
| title_sort | no go decay mrna cleavage in the ribosome exit tunnel produces 5 oh ends phosphorylated by trl1 |
| url | https://doi.org/10.1038/s41467-019-13991-9 |
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