Imaging Features of Mucinous Carcinoma of the Breast
A 57-year-old female, a housewife, presented with complaints of a gradually increasing lump in the left breast for two months. There was no history of nipple discharge, weight loss, or loss of appetite. Additionally, there was no family history of breast carcinoma. On local examination and palpation...
| المؤلفون الرئيسيون: | , , , |
|---|---|
| التنسيق: | مقال |
| اللغة: | English |
| منشور في: |
JCDR Research and Publications Private Limited
2024-03-01
|
| سلاسل: | Journal of Clinical and Diagnostic Research |
| الموضوعات: | |
| الوصول للمادة أونلاين: | https://www.jcdr.net/articles/PDF/19197/67543_CE[Ra1]_F(KR)_QC(KK_RDW_IS)_PF1(R1_DK)_PFA(RI_KM)_PN(KM).pdf |
| _version_ | 1827318952839086080 |
|---|---|
| author | Kondampally Varsha Reddy Mandadapu Sri Padma Bandari Kaavya Senthil Kumar Aiyappan |
| author_facet | Kondampally Varsha Reddy Mandadapu Sri Padma Bandari Kaavya Senthil Kumar Aiyappan |
| author_sort | Kondampally Varsha Reddy |
| collection | DOAJ |
| description | A 57-year-old female, a housewife, presented with complaints of a gradually increasing lump in the left breast for two months. There was no history of nipple discharge, weight loss, or loss of appetite. Additionally, there was no family history of breast carcinoma. On local examination and palpation of the left breast, a palpable lump measuring 6x6 cm was found. The lump involved the retroareolar and lower outer quadrant, and it had a firm consistency and was mobile. The overlying skin was pinchable. The nipple-areolar complex and left axilla were normal. The lump was non tender. The patient was then referred for mammography and ultrasound of the breast. The ultrasound revealed a hypo to isoechoic lesion measuring 5.3x2.7 cm with microlobulations and minimal peripheral vascularity in the lower outer quadrant of the left breast [Table/Fig-1a,b]. No significant left axillary lymph nodes were detected. The mammography showed a relatively high-density lobulated well-defined mass in the retroareolar and lower outer quadrant of the left breast. No microcalcifications or surrounding architectural distortion were detected [Table/Fig-2a,b]. Radiologically, a Breast-imaging Reporting and Data System (BI-RADS) 3 or 4a lesion was considered since the lesion had well-defined lobulated margins. Magnetic Resonance Imaging (MRI) was performed, which showed a well-defined lobulated mass without diffusion restriction, mimicking a benign lesion [Table/Fig-3a,b]. The patient then underwent fine needle aspiration cytology, which revealed Mucinous Carcinoma (MC) of the breast. Subsequently, the patient underwent a modified radical mastectomy after a metastatic work-up. There was no evidence of distant metastasis on chest X-ray, abdominal ultrasound, and bone scan. The patient was not able to afford Positron Emission Tomography-computed Tomography (PET-CT). The resected specimen showed features of MC of the breast with pathological staging of pT1bN0Mx. Two axillary lymph nodes were resected, and they were free of tumour. The tumour was unifocal with a histological grade of 2. The cancer was both Estrogen Receptor (ER) and Progesterone Receptor (PR) positive, Human Epidermal Growth Factor Receptor (HER2) 2 negative. The mucin content was over 90%, suggesting the pure mucinous variety rather than the mixed variety. The patient was then referred to a medical oncologist for chemotherapy. The patient is presently doing well after six months of follow-up. |
| first_indexed | 2024-04-25T00:11:31Z |
| format | Article |
| id | doaj.art-a8fe2c0d75e94e9cb0230c0e1ba98f0a |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-25T00:11:31Z |
| publishDate | 2024-03-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-a8fe2c0d75e94e9cb0230c0e1ba98f0a2024-03-13T11:35:37ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2024-03-011803010210.7860/JCDR/2024/67543.19197Imaging Features of Mucinous Carcinoma of the BreastKondampally Varsha Reddy0Mandadapu Sri Padma1Bandari Kaavya2Senthil Kumar Aiyappan3Junior Resident, Department of Radiodiagnosis, SRM Medical College Hospital and Research Centre, SRMIST, Kattankulathur, Chengalpattu, Tamil Nadu, India.Junior Resident, Department of Radiodiagnosis, SRM Medical College Hospital and Research Centre, SRMIST, Kattankulathur, Chengalpattu, Tamil Nadu, India.Junior Resident, Department of Radiodiagnosis, SRM Medical College Hospital and Research Centre, SRMIST, Kattankulathur, Chengalpattu, Tamil Nadu, India.Professor and Head, Department of Radiodiagnosis, SRM Medical College Hospital and Research Centre, SRMIST, Kattankulathur, Chengalpattu, Tamil Nadu, India.A 57-year-old female, a housewife, presented with complaints of a gradually increasing lump in the left breast for two months. There was no history of nipple discharge, weight loss, or loss of appetite. Additionally, there was no family history of breast carcinoma. On local examination and palpation of the left breast, a palpable lump measuring 6x6 cm was found. The lump involved the retroareolar and lower outer quadrant, and it had a firm consistency and was mobile. The overlying skin was pinchable. The nipple-areolar complex and left axilla were normal. The lump was non tender. The patient was then referred for mammography and ultrasound of the breast. The ultrasound revealed a hypo to isoechoic lesion measuring 5.3x2.7 cm with microlobulations and minimal peripheral vascularity in the lower outer quadrant of the left breast [Table/Fig-1a,b]. No significant left axillary lymph nodes were detected. The mammography showed a relatively high-density lobulated well-defined mass in the retroareolar and lower outer quadrant of the left breast. No microcalcifications or surrounding architectural distortion were detected [Table/Fig-2a,b]. Radiologically, a Breast-imaging Reporting and Data System (BI-RADS) 3 or 4a lesion was considered since the lesion had well-defined lobulated margins. Magnetic Resonance Imaging (MRI) was performed, which showed a well-defined lobulated mass without diffusion restriction, mimicking a benign lesion [Table/Fig-3a,b]. The patient then underwent fine needle aspiration cytology, which revealed Mucinous Carcinoma (MC) of the breast. Subsequently, the patient underwent a modified radical mastectomy after a metastatic work-up. There was no evidence of distant metastasis on chest X-ray, abdominal ultrasound, and bone scan. The patient was not able to afford Positron Emission Tomography-computed Tomography (PET-CT). The resected specimen showed features of MC of the breast with pathological staging of pT1bN0Mx. Two axillary lymph nodes were resected, and they were free of tumour. The tumour was unifocal with a histological grade of 2. The cancer was both Estrogen Receptor (ER) and Progesterone Receptor (PR) positive, Human Epidermal Growth Factor Receptor (HER2) 2 negative. The mucin content was over 90%, suggesting the pure mucinous variety rather than the mixed variety. The patient was then referred to a medical oncologist for chemotherapy. The patient is presently doing well after six months of follow-up.https://www.jcdr.net/articles/PDF/19197/67543_CE[Ra1]_F(KR)_QC(KK_RDW_IS)_PF1(R1_DK)_PFA(RI_KM)_PN(KM).pdfmagnetic resonance imagingmammographyultrasound |
| spellingShingle | Kondampally Varsha Reddy Mandadapu Sri Padma Bandari Kaavya Senthil Kumar Aiyappan Imaging Features of Mucinous Carcinoma of the Breast Journal of Clinical and Diagnostic Research magnetic resonance imaging mammography ultrasound |
| title | Imaging Features of Mucinous Carcinoma of the Breast |
| title_full | Imaging Features of Mucinous Carcinoma of the Breast |
| title_fullStr | Imaging Features of Mucinous Carcinoma of the Breast |
| title_full_unstemmed | Imaging Features of Mucinous Carcinoma of the Breast |
| title_short | Imaging Features of Mucinous Carcinoma of the Breast |
| title_sort | imaging features of mucinous carcinoma of the breast |
| topic | magnetic resonance imaging mammography ultrasound |
| url | https://www.jcdr.net/articles/PDF/19197/67543_CE[Ra1]_F(KR)_QC(KK_RDW_IS)_PF1(R1_DK)_PFA(RI_KM)_PN(KM).pdf |
| work_keys_str_mv | AT kondampallyvarshareddy imagingfeaturesofmucinouscarcinomaofthebreast AT mandadapusripadma imagingfeaturesofmucinouscarcinomaofthebreast AT bandarikaavya imagingfeaturesofmucinouscarcinomaofthebreast AT senthilkumaraiyappan imagingfeaturesofmucinouscarcinomaofthebreast |