Biodistribution and Clearance of TiO2 Nanoparticles in Rats after Intravenous Injection.
Titanium dioxide (TiO2) nanoparticles are used in many applications. Due to their small size, easy body penetration and toxicological adverse effects have been suspected. Numerous studies have tried to characterize TiO2 translocation after oral, dermal or respiratory exposure. In this study, we focu...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0124490 |
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author | Dan Elgrabli Remy Beaudouin Nawel Jbilou Magali Floriani Alexandre Pery Françoise Rogerieux Ghislaine Lacroix |
author_facet | Dan Elgrabli Remy Beaudouin Nawel Jbilou Magali Floriani Alexandre Pery Françoise Rogerieux Ghislaine Lacroix |
author_sort | Dan Elgrabli |
collection | DOAJ |
description | Titanium dioxide (TiO2) nanoparticles are used in many applications. Due to their small size, easy body penetration and toxicological adverse effects have been suspected. Numerous studies have tried to characterize TiO2 translocation after oral, dermal or respiratory exposure. In this study, we focused on TiO2 nanoparticle biodistribution, clearance and toxicological effects after intravenous injection, considering TiO2 translocation in the blood occurs. Using ICP-OES, transmission electron microscopy, and histological methods, we found TiO2 accumulation in liver, lungs and spleen. We estimated TiO2 nanoparticles' half life in the body to about 10 days. Clinical biomarkers were also quantified for 56 days to identify potential toxicological impact on lungs, blood, liver, spleen and kidneys. Results showed absence of toxicological effects after TiO2 intravenous injection at concentrations of 7.7 to 9.4 mg/kg. |
first_indexed | 2024-12-19T00:15:43Z |
format | Article |
id | doaj.art-a9029e883ede4206b28b9f1d33764e15 |
institution | Directory Open Access Journal |
issn | 1932-6203 |
language | English |
last_indexed | 2024-12-19T00:15:43Z |
publishDate | 2015-01-01 |
publisher | Public Library of Science (PLoS) |
record_format | Article |
series | PLoS ONE |
spelling | doaj.art-a9029e883ede4206b28b9f1d33764e152022-12-21T20:45:51ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01104e012449010.1371/journal.pone.0124490Biodistribution and Clearance of TiO2 Nanoparticles in Rats after Intravenous Injection.Dan ElgrabliRemy BeaudouinNawel JbilouMagali FlorianiAlexandre PeryFrançoise RogerieuxGhislaine LacroixTitanium dioxide (TiO2) nanoparticles are used in many applications. Due to their small size, easy body penetration and toxicological adverse effects have been suspected. Numerous studies have tried to characterize TiO2 translocation after oral, dermal or respiratory exposure. In this study, we focused on TiO2 nanoparticle biodistribution, clearance and toxicological effects after intravenous injection, considering TiO2 translocation in the blood occurs. Using ICP-OES, transmission electron microscopy, and histological methods, we found TiO2 accumulation in liver, lungs and spleen. We estimated TiO2 nanoparticles' half life in the body to about 10 days. Clinical biomarkers were also quantified for 56 days to identify potential toxicological impact on lungs, blood, liver, spleen and kidneys. Results showed absence of toxicological effects after TiO2 intravenous injection at concentrations of 7.7 to 9.4 mg/kg.https://doi.org/10.1371/journal.pone.0124490 |
spellingShingle | Dan Elgrabli Remy Beaudouin Nawel Jbilou Magali Floriani Alexandre Pery Françoise Rogerieux Ghislaine Lacroix Biodistribution and Clearance of TiO2 Nanoparticles in Rats after Intravenous Injection. PLoS ONE |
title | Biodistribution and Clearance of TiO2 Nanoparticles in Rats after Intravenous Injection. |
title_full | Biodistribution and Clearance of TiO2 Nanoparticles in Rats after Intravenous Injection. |
title_fullStr | Biodistribution and Clearance of TiO2 Nanoparticles in Rats after Intravenous Injection. |
title_full_unstemmed | Biodistribution and Clearance of TiO2 Nanoparticles in Rats after Intravenous Injection. |
title_short | Biodistribution and Clearance of TiO2 Nanoparticles in Rats after Intravenous Injection. |
title_sort | biodistribution and clearance of tio2 nanoparticles in rats after intravenous injection |
url | https://doi.org/10.1371/journal.pone.0124490 |
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