Biodistribution and Clearance of TiO2 Nanoparticles in Rats after Intravenous Injection.

Titanium dioxide (TiO2) nanoparticles are used in many applications. Due to their small size, easy body penetration and toxicological adverse effects have been suspected. Numerous studies have tried to characterize TiO2 translocation after oral, dermal or respiratory exposure. In this study, we focu...

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Main Authors: Dan Elgrabli, Remy Beaudouin, Nawel Jbilou, Magali Floriani, Alexandre Pery, Françoise Rogerieux, Ghislaine Lacroix
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0124490
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author Dan Elgrabli
Remy Beaudouin
Nawel Jbilou
Magali Floriani
Alexandre Pery
Françoise Rogerieux
Ghislaine Lacroix
author_facet Dan Elgrabli
Remy Beaudouin
Nawel Jbilou
Magali Floriani
Alexandre Pery
Françoise Rogerieux
Ghislaine Lacroix
author_sort Dan Elgrabli
collection DOAJ
description Titanium dioxide (TiO2) nanoparticles are used in many applications. Due to their small size, easy body penetration and toxicological adverse effects have been suspected. Numerous studies have tried to characterize TiO2 translocation after oral, dermal or respiratory exposure. In this study, we focused on TiO2 nanoparticle biodistribution, clearance and toxicological effects after intravenous injection, considering TiO2 translocation in the blood occurs. Using ICP-OES, transmission electron microscopy, and histological methods, we found TiO2 accumulation in liver, lungs and spleen. We estimated TiO2 nanoparticles' half life in the body to about 10 days. Clinical biomarkers were also quantified for 56 days to identify potential toxicological impact on lungs, blood, liver, spleen and kidneys. Results showed absence of toxicological effects after TiO2 intravenous injection at concentrations of 7.7 to 9.4 mg/kg.
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spelling doaj.art-a9029e883ede4206b28b9f1d33764e152022-12-21T20:45:51ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01104e012449010.1371/journal.pone.0124490Biodistribution and Clearance of TiO2 Nanoparticles in Rats after Intravenous Injection.Dan ElgrabliRemy BeaudouinNawel JbilouMagali FlorianiAlexandre PeryFrançoise RogerieuxGhislaine LacroixTitanium dioxide (TiO2) nanoparticles are used in many applications. Due to their small size, easy body penetration and toxicological adverse effects have been suspected. Numerous studies have tried to characterize TiO2 translocation after oral, dermal or respiratory exposure. In this study, we focused on TiO2 nanoparticle biodistribution, clearance and toxicological effects after intravenous injection, considering TiO2 translocation in the blood occurs. Using ICP-OES, transmission electron microscopy, and histological methods, we found TiO2 accumulation in liver, lungs and spleen. We estimated TiO2 nanoparticles' half life in the body to about 10 days. Clinical biomarkers were also quantified for 56 days to identify potential toxicological impact on lungs, blood, liver, spleen and kidneys. Results showed absence of toxicological effects after TiO2 intravenous injection at concentrations of 7.7 to 9.4 mg/kg.https://doi.org/10.1371/journal.pone.0124490
spellingShingle Dan Elgrabli
Remy Beaudouin
Nawel Jbilou
Magali Floriani
Alexandre Pery
Françoise Rogerieux
Ghislaine Lacroix
Biodistribution and Clearance of TiO2 Nanoparticles in Rats after Intravenous Injection.
PLoS ONE
title Biodistribution and Clearance of TiO2 Nanoparticles in Rats after Intravenous Injection.
title_full Biodistribution and Clearance of TiO2 Nanoparticles in Rats after Intravenous Injection.
title_fullStr Biodistribution and Clearance of TiO2 Nanoparticles in Rats after Intravenous Injection.
title_full_unstemmed Biodistribution and Clearance of TiO2 Nanoparticles in Rats after Intravenous Injection.
title_short Biodistribution and Clearance of TiO2 Nanoparticles in Rats after Intravenous Injection.
title_sort biodistribution and clearance of tio2 nanoparticles in rats after intravenous injection
url https://doi.org/10.1371/journal.pone.0124490
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