Decorating and loading ghosts with allergens for allergen immunotherapy
More than 25% of the global population has IgE mediated allergic diseases. Allergen immunotherapy (AIT) is the only available form of treatment that alters the underlying mechanism of IgE-mediated allergic diseases. AIT is aimed at desensitizing allergic individuals by repeatedly administering disea...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-10-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2017.1365208 |
| _version_ | 1797677565626810368 |
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| author | Songwe Fanuel Saeideh Tabesh Huda Fatima Rajani Sahel Heidari Esmaeil Sadroddiny Gholam Ali Kardar |
| author_facet | Songwe Fanuel Saeideh Tabesh Huda Fatima Rajani Sahel Heidari Esmaeil Sadroddiny Gholam Ali Kardar |
| author_sort | Songwe Fanuel |
| collection | DOAJ |
| description | More than 25% of the global population has IgE mediated allergic diseases. Allergen immunotherapy (AIT) is the only available form of treatment that alters the underlying mechanism of IgE-mediated allergic diseases. AIT is aimed at desensitizing allergic individuals by repeatedly administering disease-causing allergens over a long period of time. Despite its proven efficacy in numerous clinical trials, the effectiveness of AIT still suffers some drawbacks due to the quality of allergens used and in particular the unavailability of efficient allergen delivery systems. Several studies have demonstrated that bacterial ghosts (BG) systems can be used to display and deliver antigens to their targets for the management of diseases. However, there is no report documenting the use of BG systems for immunotherapy of IgE-mediated diseases so far. Thus, in this review, we intend to discuss the potentialities of BG systems for displaying and delivering allergens for future management of IgE-mediated diseases. |
| first_indexed | 2024-03-11T22:47:07Z |
| format | Article |
| id | doaj.art-a902d659f24e434d9019d1468e2dca31 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:47:07Z |
| publishDate | 2017-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-a902d659f24e434d9019d1468e2dca312023-09-22T08:17:52ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2017-10-0113102428243310.1080/21645515.2017.13652081365208Decorating and loading ghosts with allergens for allergen immunotherapySongwe Fanuel0Saeideh Tabesh1Huda Fatima Rajani2Sahel Heidari3Esmaeil Sadroddiny4Gholam Ali Kardar5School of Advanced Technologies in Medicine, Tehran University of Medical Sciences-International Campus (IC-TUMS)School of Public Health, Tehran University of Medical SciencesSchool of Advanced Technologies in Medicine, Tehran University of Medical Sciences-International Campus (IC-TUMS)School of Medicine, Iran University of Medical SciencesSchool of Advanced Technologies in Medicine, Tehran University of Medical Sciences-International Campus (IC-TUMS)School of Advanced Technologies in Medicine, Tehran University of Medical Sciences-International Campus (IC-TUMS)More than 25% of the global population has IgE mediated allergic diseases. Allergen immunotherapy (AIT) is the only available form of treatment that alters the underlying mechanism of IgE-mediated allergic diseases. AIT is aimed at desensitizing allergic individuals by repeatedly administering disease-causing allergens over a long period of time. Despite its proven efficacy in numerous clinical trials, the effectiveness of AIT still suffers some drawbacks due to the quality of allergens used and in particular the unavailability of efficient allergen delivery systems. Several studies have demonstrated that bacterial ghosts (BG) systems can be used to display and deliver antigens to their targets for the management of diseases. However, there is no report documenting the use of BG systems for immunotherapy of IgE-mediated diseases so far. Thus, in this review, we intend to discuss the potentialities of BG systems for displaying and delivering allergens for future management of IgE-mediated diseases.http://dx.doi.org/10.1080/21645515.2017.1365208allergensbacterial ghostshypersensitivityimmunotherapyvaccine |
| spellingShingle | Songwe Fanuel Saeideh Tabesh Huda Fatima Rajani Sahel Heidari Esmaeil Sadroddiny Gholam Ali Kardar Decorating and loading ghosts with allergens for allergen immunotherapy Human Vaccines & Immunotherapeutics allergens bacterial ghosts hypersensitivity immunotherapy vaccine |
| title | Decorating and loading ghosts with allergens for allergen immunotherapy |
| title_full | Decorating and loading ghosts with allergens for allergen immunotherapy |
| title_fullStr | Decorating and loading ghosts with allergens for allergen immunotherapy |
| title_full_unstemmed | Decorating and loading ghosts with allergens for allergen immunotherapy |
| title_short | Decorating and loading ghosts with allergens for allergen immunotherapy |
| title_sort | decorating and loading ghosts with allergens for allergen immunotherapy |
| topic | allergens bacterial ghosts hypersensitivity immunotherapy vaccine |
| url | http://dx.doi.org/10.1080/21645515.2017.1365208 |
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