Prevalence of hyperuricemia in children with leukemia and lymphoma with respect to prophylactic treatment
Background: Hyperuricemia is one of the oncologic emergency that occurs most often in patients with hematologic disorders particularly leukemia and high-grade lymphoma. This study was conducted in order to determine the prevalence of hyperuricemia with respect to prophylactic treatment (in particula...
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| Format: | Article |
| Language: | fas |
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Tehran University of Medical Sciences
2007-06-01
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| Series: | Tehran University Medical Journal |
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| Online Access: | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/3419.pdf&manuscript_id=3419 |
| _version_ | 1818155686084739072 |
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| author | Oloomi Z Moayeri H Bahremand Sh Vafaei P |
| author_facet | Oloomi Z Moayeri H Bahremand Sh Vafaei P |
| author_sort | Oloomi Z |
| collection | DOAJ |
| description | Background: Hyperuricemia is one of the oncologic emergency that occurs most often in patients with hematologic disorders particularly leukemia and high-grade lymphoma. This study was conducted in order to determine the prevalence of hyperuricemia with respect to prophylactic treatment (in particular allopurinol) in patients with lymphoproliferative disease in the pediatric hematologic ward of Imam Khomeini Hospital, Tehran. Methods: In this retrospective cross-sectional study, 316 children (75 females, 241 males) under the age of 12 years participated. Among the subjects, 66 patients (20.9%) had lymphoma and 250 patients (79.1%) had leukemia. Results: Of the 56 (17.7%) patients diagnosed with hyperuricemia, 13 with lymphoma (19.7%) and 43 (17.2%) with acute lymphoblastic leukemia, 52 patients showed hyperuricemia after induction of chemotherapy (p<0.001). Hyperuricemia was more prevalent in patients with more advanced disease (50.9% in stage IV, p<0.001). Hyperuricemia was more frequent in male patients (p<0.001). Among the 217 patients who had received prophylaxis (hydration, alkalization, allopurinol), 19 (8.7%) subjects had hyperuricemia compare to 37.3% in the group of patients who did not receive prophylactic treatment (p<0.001). Conclusion: From the literature reviewed, a recombinant form of the urate oxidase enzyme (rasburicase) is a safe and effective alternative to allopurinol to rapidly control plasma uric acid concentrations in patients with hematologic malignancy at high risk for tumor lysis during induction of chemotherapy. In this respect, we recommend a prospective study to compare allopurinol and rasburicase in children with leukemia and lymphoma. |
| first_indexed | 2024-12-11T14:46:21Z |
| format | Article |
| id | doaj.art-a90316f11ba84eb9b42ab37af2a0b7a6 |
| institution | Directory Open Access Journal |
| issn | 1683-1764 1735-7322 |
| language | fas |
| last_indexed | 2024-12-11T14:46:21Z |
| publishDate | 2007-06-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Tehran University Medical Journal |
| spelling | doaj.art-a90316f11ba84eb9b42ab37af2a0b7a62022-12-22T01:01:40ZfasTehran University of Medical SciencesTehran University Medical Journal1683-17641735-73222007-06-016517479Prevalence of hyperuricemia in children with leukemia and lymphoma with respect to prophylactic treatmentOloomi ZMoayeri HBahremand ShVafaei PBackground: Hyperuricemia is one of the oncologic emergency that occurs most often in patients with hematologic disorders particularly leukemia and high-grade lymphoma. This study was conducted in order to determine the prevalence of hyperuricemia with respect to prophylactic treatment (in particular allopurinol) in patients with lymphoproliferative disease in the pediatric hematologic ward of Imam Khomeini Hospital, Tehran. Methods: In this retrospective cross-sectional study, 316 children (75 females, 241 males) under the age of 12 years participated. Among the subjects, 66 patients (20.9%) had lymphoma and 250 patients (79.1%) had leukemia. Results: Of the 56 (17.7%) patients diagnosed with hyperuricemia, 13 with lymphoma (19.7%) and 43 (17.2%) with acute lymphoblastic leukemia, 52 patients showed hyperuricemia after induction of chemotherapy (p<0.001). Hyperuricemia was more prevalent in patients with more advanced disease (50.9% in stage IV, p<0.001). Hyperuricemia was more frequent in male patients (p<0.001). Among the 217 patients who had received prophylaxis (hydration, alkalization, allopurinol), 19 (8.7%) subjects had hyperuricemia compare to 37.3% in the group of patients who did not receive prophylactic treatment (p<0.001). Conclusion: From the literature reviewed, a recombinant form of the urate oxidase enzyme (rasburicase) is a safe and effective alternative to allopurinol to rapidly control plasma uric acid concentrations in patients with hematologic malignancy at high risk for tumor lysis during induction of chemotherapy. In this respect, we recommend a prospective study to compare allopurinol and rasburicase in children with leukemia and lymphoma.http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/3419.pdf&manuscript_id=3419HyperuricemiaProphylactic treatment |
| spellingShingle | Oloomi Z Moayeri H Bahremand Sh Vafaei P Prevalence of hyperuricemia in children with leukemia and lymphoma with respect to prophylactic treatment Tehran University Medical Journal Hyperuricemia Prophylactic treatment |
| title | Prevalence of hyperuricemia in children with leukemia and lymphoma with respect to prophylactic treatment |
| title_full | Prevalence of hyperuricemia in children with leukemia and lymphoma with respect to prophylactic treatment |
| title_fullStr | Prevalence of hyperuricemia in children with leukemia and lymphoma with respect to prophylactic treatment |
| title_full_unstemmed | Prevalence of hyperuricemia in children with leukemia and lymphoma with respect to prophylactic treatment |
| title_short | Prevalence of hyperuricemia in children with leukemia and lymphoma with respect to prophylactic treatment |
| title_sort | prevalence of hyperuricemia in children with leukemia and lymphoma with respect to prophylactic treatment |
| topic | Hyperuricemia Prophylactic treatment |
| url | http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/3419.pdf&manuscript_id=3419 |
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