A next generation peripherally restricted Cavα2δ-1 ligand with inhibitory action on Cav2.2 channels and utility in neuropathic pain

A next generation peripherally restricted Cavα2δ-1 ligand with inhibitory action on Cav2.2 channels and utility in neuropathic pain

The Voltage-Gated Calcium Channel (VGCC) auxiliary subunit Cavα2δ-1 (CACNA2D1) is the target/receptor of gabapentinoids which are known therapeutics in epilepsy and neuropathic pain. Following damage to the peripheral sensory nervous system, Cavα2δ-1 is upregulated in dorsal root ganglion (DRG) neur...

Full description

Bibliographic Details
Main Authors: Franz Kricek, Christine Ruf, Premji Meghani, Ivana A. Souza, Maria A. Gandini, Gerald W. Zamponi, George Skouteris
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Chronic Pain
VGCC
CACNA2D1
Gabapentinoids
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224003561

Similar Items

Similar Items