Experimental Investigation of Magnetic Nanoparticle-Enhanced Microwave Hyperthermia
The objective of this study was to evaluate microwave heating enhancements offered by iron/iron oxide nanoparticles dispersed within tissue-mimicking media for improving efficacy of microwave thermal therapy. The following dopamine-coated magnetic nanoparticles (MNPs) were considered: 10 and 20 nm d...
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| Format: | Article |
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MDPI AG
2017-06-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | http://www.mdpi.com/2079-4983/8/3/21 |
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| author | Brogan T. McWilliams Hongwang Wang Valerie J. Binns Sergio Curto Stefan H. Bossmann Punit Prakash |
| author_facet | Brogan T. McWilliams Hongwang Wang Valerie J. Binns Sergio Curto Stefan H. Bossmann Punit Prakash |
| author_sort | Brogan T. McWilliams |
| collection | DOAJ |
| description | The objective of this study was to evaluate microwave heating enhancements offered by iron/iron oxide nanoparticles dispersed within tissue-mimicking media for improving efficacy of microwave thermal therapy. The following dopamine-coated magnetic nanoparticles (MNPs) were considered: 10 and 20 nm diameter spherical core/shell Fe/Fe3O4, 20 nm edge-length cubic Fe3O4, and 45 nm edge-length/10 nm height hexagonal Fe3O4. Microwave heating enhancements were experimentally measured with MNPs dissolved in an agar phantom, placed within a rectangular waveguide. Effects of MNP concentration (2.5–20 mg/mL) and microwave frequency (2.0, 2.45 and 2.6 GHz) were evaluated. Further tests with 10 and 20 nm diameter spherical MNPs dispersed within a two-compartment tissue-mimicking phantom were performed with an interstitial dipole antenna radiating 15 W power at 2.45 GHz. Microwave heating of 5 mg/mL MNP-agar phantom mixtures with 10 and 20 nm spherical, and hexagonal MNPs in a waveguide yielded heating rates of 0.78 ± 0.02 °C/s, 0.72 ± 0.01 °C/s and 0.51 ± 0.03 °C/s, respectively, compared to 0.5 ± 0.1 °C/s for control. Greater heating enhancements were observed at 2.0 GHz compared to 2.45 and 2.6 GHz. Heating experiments in two-compartment phantoms with an interstitial dipole antenna demonstrated potential for extending the radial extent of therapeutic heating with 10 and 20 nm diameter spherical MNPs, compared to homogeneous phantoms (i.e., without MNPs). Of the MNPs considered in this study, spherical Fe/Fe3O4 nanoparticles offer the greatest heating enhancement when exposed to microwave radiation. These nanoparticles show strong potential for enhancing the rate of heating and radial extent of heating during microwave hyperthermia and ablation procedures. |
| first_indexed | 2024-04-11T12:41:11Z |
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| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-04-11T12:41:11Z |
| publishDate | 2017-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-a907f439b45e4ca5856bdc517e7062bf2022-12-22T04:23:30ZengMDPI AGJournal of Functional Biomaterials2079-49832017-06-01832110.3390/jfb8030021jfb8030021Experimental Investigation of Magnetic Nanoparticle-Enhanced Microwave HyperthermiaBrogan T. McWilliams0Hongwang Wang1Valerie J. Binns2Sergio Curto3Stefan H. Bossmann4Punit Prakash5Department of Electrical and Computer Engineering, Kansas State University, 3078 Engineering Hall, Manhattan, KS 66506, USADepartment of Chemistry, Kansas State University, 213 CBC Building, Manhattan, KS 66506, USADepartment of Electrical and Computer Engineering, Kansas State University, 3078 Engineering Hall, Manhattan, KS 66506, USADepartment of Electrical and Computer Engineering, Kansas State University, 3078 Engineering Hall, Manhattan, KS 66506, USADepartment of Chemistry, Kansas State University, 213 CBC Building, Manhattan, KS 66506, USADepartment of Electrical and Computer Engineering, Kansas State University, 3078 Engineering Hall, Manhattan, KS 66506, USAThe objective of this study was to evaluate microwave heating enhancements offered by iron/iron oxide nanoparticles dispersed within tissue-mimicking media for improving efficacy of microwave thermal therapy. The following dopamine-coated magnetic nanoparticles (MNPs) were considered: 10 and 20 nm diameter spherical core/shell Fe/Fe3O4, 20 nm edge-length cubic Fe3O4, and 45 nm edge-length/10 nm height hexagonal Fe3O4. Microwave heating enhancements were experimentally measured with MNPs dissolved in an agar phantom, placed within a rectangular waveguide. Effects of MNP concentration (2.5–20 mg/mL) and microwave frequency (2.0, 2.45 and 2.6 GHz) were evaluated. Further tests with 10 and 20 nm diameter spherical MNPs dispersed within a two-compartment tissue-mimicking phantom were performed with an interstitial dipole antenna radiating 15 W power at 2.45 GHz. Microwave heating of 5 mg/mL MNP-agar phantom mixtures with 10 and 20 nm spherical, and hexagonal MNPs in a waveguide yielded heating rates of 0.78 ± 0.02 °C/s, 0.72 ± 0.01 °C/s and 0.51 ± 0.03 °C/s, respectively, compared to 0.5 ± 0.1 °C/s for control. Greater heating enhancements were observed at 2.0 GHz compared to 2.45 and 2.6 GHz. Heating experiments in two-compartment phantoms with an interstitial dipole antenna demonstrated potential for extending the radial extent of therapeutic heating with 10 and 20 nm diameter spherical MNPs, compared to homogeneous phantoms (i.e., without MNPs). Of the MNPs considered in this study, spherical Fe/Fe3O4 nanoparticles offer the greatest heating enhancement when exposed to microwave radiation. These nanoparticles show strong potential for enhancing the rate of heating and radial extent of heating during microwave hyperthermia and ablation procedures.http://www.mdpi.com/2079-4983/8/3/21magnetic nanoparticlesmicrowave hyperthermiamicrowave ablationnanoparticle-enhanced thermal therapy |
| spellingShingle | Brogan T. McWilliams Hongwang Wang Valerie J. Binns Sergio Curto Stefan H. Bossmann Punit Prakash Experimental Investigation of Magnetic Nanoparticle-Enhanced Microwave Hyperthermia Journal of Functional Biomaterials magnetic nanoparticles microwave hyperthermia microwave ablation nanoparticle-enhanced thermal therapy |
| title | Experimental Investigation of Magnetic Nanoparticle-Enhanced Microwave Hyperthermia |
| title_full | Experimental Investigation of Magnetic Nanoparticle-Enhanced Microwave Hyperthermia |
| title_fullStr | Experimental Investigation of Magnetic Nanoparticle-Enhanced Microwave Hyperthermia |
| title_full_unstemmed | Experimental Investigation of Magnetic Nanoparticle-Enhanced Microwave Hyperthermia |
| title_short | Experimental Investigation of Magnetic Nanoparticle-Enhanced Microwave Hyperthermia |
| title_sort | experimental investigation of magnetic nanoparticle enhanced microwave hyperthermia |
| topic | magnetic nanoparticles microwave hyperthermia microwave ablation nanoparticle-enhanced thermal therapy |
| url | http://www.mdpi.com/2079-4983/8/3/21 |
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