Changing the airway pH: is it helping asthma control?
Background Although airway hyperacidity may have a great effect in the pathogenesis of asthma, its evaluation may be difficult. This study was conducted at Mansoura University Hospitals aiming to evaluate the degree of asthma control by increasing pH in uncontrolled asthma cases by the use of inhale...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2021-01-01
|
| Series: | Egyptian Journal of Chest Disease and Tuberculosis |
| Subjects: | |
| Online Access: | http://www.ejcdt.eg.net/article.asp?issn=0422-7638;year=2021;volume=70;issue=1;spage=48;epage=53;aulast=Rezk |
| _version_ | 1818445217982840832 |
|---|---|
| author | Nasef Abd-Elsalam Rezk Ahmed Alshamy Mohamed Shehta Nesreen Elsyed Morsy Mohamed Alnahas |
| author_facet | Nasef Abd-Elsalam Rezk Ahmed Alshamy Mohamed Shehta Nesreen Elsyed Morsy Mohamed Alnahas |
| author_sort | Nasef Abd-Elsalam Rezk |
| collection | DOAJ |
| description | Background Although airway hyperacidity may have a great effect in the pathogenesis of asthma, its evaluation may be difficult. This study was conducted at Mansoura University Hospitals aiming to evaluate the degree of asthma control by increasing pH in uncontrolled asthma cases by the use of inhaled NaHCO3 8.4% for 3 months.
Patients and methods A total of 100 patients with asthma were included, and they were divided by simple randomization to 75 patients in study group and 25 controls. All participants were subjected to history taking, clinical examination, sputum cell count and pH assessment, PFT, high-resolution computed tomography, and sputum induction and NaHCO3 8.4% inhalation. Evaluation of asthma exacerbation 6 months before and after intervention was carried out.
Results There was no significant difference between study and control groups regarding demographic data, all basic investigations, pulmonary function, or sputum total and differential cells. We found a significant increase of sputum pH after treatment in the study group. Furthermore, significant improvement of forced expiratory volume in 1 s, forced vital capacity, four parameters of control assessment, and exacerbation also was seen in the study group after treatment. There was a significant decrease of total cells and eosinophils in sputum in the study group. The linear regression model showed a significant negative correlation for all the studied factors except short-acting beta 2 (SABA) and day symptom improvement.
Conclusion We conclude that the decrease of airway acidity by NaHCO3 8.4% leads to significant decrease in inflammatory cells and frequency of exacerbation and improves pulmonary function in poorly controlled bronchial asthma. |
| first_indexed | 2024-12-14T19:28:20Z |
| format | Article |
| id | doaj.art-a90919ed22464d698177678a7fe38e8e |
| institution | Directory Open Access Journal |
| issn | 0422-7638 2090-9950 |
| language | English |
| last_indexed | 2024-12-14T19:28:20Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Egyptian Journal of Chest Disease and Tuberculosis |
| spelling | doaj.art-a90919ed22464d698177678a7fe38e8e2022-12-21T22:50:08ZengWolters Kluwer Medknow PublicationsEgyptian Journal of Chest Disease and Tuberculosis0422-76382090-99502021-01-01701485310.4103/ejcdt.ejcdt_98_20Changing the airway pH: is it helping asthma control?Nasef Abd-Elsalam RezkAhmed AlshamyMohamed ShehtaNesreen Elsyed MorsyMohamed AlnahasBackground Although airway hyperacidity may have a great effect in the pathogenesis of asthma, its evaluation may be difficult. This study was conducted at Mansoura University Hospitals aiming to evaluate the degree of asthma control by increasing pH in uncontrolled asthma cases by the use of inhaled NaHCO3 8.4% for 3 months. Patients and methods A total of 100 patients with asthma were included, and they were divided by simple randomization to 75 patients in study group and 25 controls. All participants were subjected to history taking, clinical examination, sputum cell count and pH assessment, PFT, high-resolution computed tomography, and sputum induction and NaHCO3 8.4% inhalation. Evaluation of asthma exacerbation 6 months before and after intervention was carried out. Results There was no significant difference between study and control groups regarding demographic data, all basic investigations, pulmonary function, or sputum total and differential cells. We found a significant increase of sputum pH after treatment in the study group. Furthermore, significant improvement of forced expiratory volume in 1 s, forced vital capacity, four parameters of control assessment, and exacerbation also was seen in the study group after treatment. There was a significant decrease of total cells and eosinophils in sputum in the study group. The linear regression model showed a significant negative correlation for all the studied factors except short-acting beta 2 (SABA) and day symptom improvement. Conclusion We conclude that the decrease of airway acidity by NaHCO3 8.4% leads to significant decrease in inflammatory cells and frequency of exacerbation and improves pulmonary function in poorly controlled bronchial asthma.http://www.ejcdt.eg.net/article.asp?issn=0422-7638;year=2021;volume=70;issue=1;spage=48;epage=53;aulast=Rezkairway acidityinhalation nahco3ph changeuncontrolled bronchial asthma |
| spellingShingle | Nasef Abd-Elsalam Rezk Ahmed Alshamy Mohamed Shehta Nesreen Elsyed Morsy Mohamed Alnahas Changing the airway pH: is it helping asthma control? Egyptian Journal of Chest Disease and Tuberculosis airway acidity inhalation nahco3 ph change uncontrolled bronchial asthma |
| title | Changing the airway pH: is it helping asthma control? |
| title_full | Changing the airway pH: is it helping asthma control? |
| title_fullStr | Changing the airway pH: is it helping asthma control? |
| title_full_unstemmed | Changing the airway pH: is it helping asthma control? |
| title_short | Changing the airway pH: is it helping asthma control? |
| title_sort | changing the airway ph is it helping asthma control |
| topic | airway acidity inhalation nahco3 ph change uncontrolled bronchial asthma |
| url | http://www.ejcdt.eg.net/article.asp?issn=0422-7638;year=2021;volume=70;issue=1;spage=48;epage=53;aulast=Rezk |
| work_keys_str_mv | AT nasefabdelsalamrezk changingtheairwayphisithelpingasthmacontrol AT ahmedalshamy changingtheairwayphisithelpingasthmacontrol AT mohamedshehta changingtheairwayphisithelpingasthmacontrol AT nesreenelsyedmorsy changingtheairwayphisithelpingasthmacontrol AT mohamedalnahas changingtheairwayphisithelpingasthmacontrol |