The associations between maternal and fetal exposure to endocrine-disrupting chemicals and asymmetric fetal growth restriction: a prospective cohort study
Recent evidence has revealed associations between endocrine-disrupting chemicals (EDCs) and placental insufficiency due to altered placental growth, syncytialization, and trophoblast invasion. However, no epidemiologic study has reported associations between exposure to EDCs and asymmetric fetal gro...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1351786/full |
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| author | Subeen Hong Byung Soo Kang Oyoung Kim Sangeun Won Hyeon Soo Kim Jeong Ha Wie Jae Eun Shin Sae Kyung Choi Yun Sung Jo Yeon Hee Kim Mihi Yang Mihi Yang Huiwon Kang Huiwon Kang Dong-Wook Lee In Yang Park Joong Shin Park Hyun Sun Ko |
| author_facet | Subeen Hong Byung Soo Kang Oyoung Kim Sangeun Won Hyeon Soo Kim Jeong Ha Wie Jae Eun Shin Sae Kyung Choi Yun Sung Jo Yeon Hee Kim Mihi Yang Mihi Yang Huiwon Kang Huiwon Kang Dong-Wook Lee In Yang Park Joong Shin Park Hyun Sun Ko |
| author_sort | Subeen Hong |
| collection | DOAJ |
| description | Recent evidence has revealed associations between endocrine-disrupting chemicals (EDCs) and placental insufficiency due to altered placental growth, syncytialization, and trophoblast invasion. However, no epidemiologic study has reported associations between exposure to EDCs and asymmetric fetal growth restriction (FGR) caused by placenta insufficiency. The aim of this study was to evaluate the association between EDC exposure and asymmetric FGR. This was a prospective cohort study including women admitted for delivery to the Maternal Fetal Center at Seoul St. Mary’s Hospital between October 2021 and October 2022. Maternal urine and cord blood samples were collected, and the levels of bisphenol-A (BPA), monoethyl phthalates, and perfluorooctanoic acid in each specimen were analyzed. We investigated linear and non-linear associations between the levels of EDCs and fetal growth parameters, including the head circumference (HC)/abdominal circumference (AC) ratio as an asymmetric parameter. The levels of EDCs were compared between fetuses with and without asymmetric FGR. Of the EDCs, only the fetal levels of BPA showed a linear association with the HC/AC ratio after adjusting for confounding variables (β = 0.003, p < 0.05). When comparing the normal growth and asymmetric FGR groups, the asymmetric FGR group showed significantly higher maternal and fetal BPA levels compared to the normal growth group (maternal urine BPA, 3.99 μg/g creatinine vs. 1.71 μg/g creatinine [p < 0.05]; cord blood BPA, 1.96 μg/L vs. −0.86 μg/L [p < 0.05]). In conclusion, fetal exposure levels of BPA show linear associations with asymmetric fetal growth patterns. High maternal and fetal exposure to BPA might be associated with asymmetric FGR. |
| first_indexed | 2024-04-24T11:19:31Z |
| format | Article |
| id | doaj.art-a90a2f7fda364657bbcb2fd3f051f28e |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-24T11:19:31Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-a90a2f7fda364657bbcb2fd3f051f28e2024-04-11T05:01:25ZengFrontiers Media S.A.Frontiers in Public Health2296-25652024-04-011210.3389/fpubh.2024.13517861351786The associations between maternal and fetal exposure to endocrine-disrupting chemicals and asymmetric fetal growth restriction: a prospective cohort studySubeen Hong0Byung Soo Kang1Oyoung Kim2Sangeun Won3Hyeon Soo Kim4Jeong Ha Wie5Jae Eun Shin6Sae Kyung Choi7Yun Sung Jo8Yeon Hee Kim9Mihi Yang10Mihi Yang11Huiwon Kang12Huiwon Kang13Dong-Wook Lee14In Yang Park15Joong Shin Park16Hyun Sun Ko17Department of Obstetrics and Gynecology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Obstetrics and Gynecology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Obstetrics and Gynecology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Obstetrics and Gynecology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Obstetrics and Gynecology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Obstetrics and Gynecology, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Obstetrics and Gynecology, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Obstetrics and Gynecology, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Obstetrics and Gynecology, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Obstetrics and Gynecology, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaCollege of Pharmacy, Sookmyung Women’s University, Seoul, Republic of KoreaGoodbeing Center Co. Ltd., Seoul, Republic of KoreaCollege of Pharmacy, Sookmyung Women’s University, Seoul, Republic of KoreaGoodbeing Center Co. Ltd., Seoul, Republic of KoreaDepartment of Occupational & Environmental Medicine, Inha University Hospital, Inha University, Incheon, Republic of KoreaDepartment of Obstetrics and Gynecology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea0Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of KoreaDepartment of Obstetrics and Gynecology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaRecent evidence has revealed associations between endocrine-disrupting chemicals (EDCs) and placental insufficiency due to altered placental growth, syncytialization, and trophoblast invasion. However, no epidemiologic study has reported associations between exposure to EDCs and asymmetric fetal growth restriction (FGR) caused by placenta insufficiency. The aim of this study was to evaluate the association between EDC exposure and asymmetric FGR. This was a prospective cohort study including women admitted for delivery to the Maternal Fetal Center at Seoul St. Mary’s Hospital between October 2021 and October 2022. Maternal urine and cord blood samples were collected, and the levels of bisphenol-A (BPA), monoethyl phthalates, and perfluorooctanoic acid in each specimen were analyzed. We investigated linear and non-linear associations between the levels of EDCs and fetal growth parameters, including the head circumference (HC)/abdominal circumference (AC) ratio as an asymmetric parameter. The levels of EDCs were compared between fetuses with and without asymmetric FGR. Of the EDCs, only the fetal levels of BPA showed a linear association with the HC/AC ratio after adjusting for confounding variables (β = 0.003, p < 0.05). When comparing the normal growth and asymmetric FGR groups, the asymmetric FGR group showed significantly higher maternal and fetal BPA levels compared to the normal growth group (maternal urine BPA, 3.99 μg/g creatinine vs. 1.71 μg/g creatinine [p < 0.05]; cord blood BPA, 1.96 μg/L vs. −0.86 μg/L [p < 0.05]). In conclusion, fetal exposure levels of BPA show linear associations with asymmetric fetal growth patterns. High maternal and fetal exposure to BPA might be associated with asymmetric FGR.https://www.frontiersin.org/articles/10.3389/fpubh.2024.1351786/fullendocrine disruptorsbisphenol-Amonoethyl phthalatesperfluorooctanoic acidfetal growth restrictionplacental insufficiency |
| spellingShingle | Subeen Hong Byung Soo Kang Oyoung Kim Sangeun Won Hyeon Soo Kim Jeong Ha Wie Jae Eun Shin Sae Kyung Choi Yun Sung Jo Yeon Hee Kim Mihi Yang Mihi Yang Huiwon Kang Huiwon Kang Dong-Wook Lee In Yang Park Joong Shin Park Hyun Sun Ko The associations between maternal and fetal exposure to endocrine-disrupting chemicals and asymmetric fetal growth restriction: a prospective cohort study Frontiers in Public Health endocrine disruptors bisphenol-A monoethyl phthalates perfluorooctanoic acid fetal growth restriction placental insufficiency |
| title | The associations between maternal and fetal exposure to endocrine-disrupting chemicals and asymmetric fetal growth restriction: a prospective cohort study |
| title_full | The associations between maternal and fetal exposure to endocrine-disrupting chemicals and asymmetric fetal growth restriction: a prospective cohort study |
| title_fullStr | The associations between maternal and fetal exposure to endocrine-disrupting chemicals and asymmetric fetal growth restriction: a prospective cohort study |
| title_full_unstemmed | The associations between maternal and fetal exposure to endocrine-disrupting chemicals and asymmetric fetal growth restriction: a prospective cohort study |
| title_short | The associations between maternal and fetal exposure to endocrine-disrupting chemicals and asymmetric fetal growth restriction: a prospective cohort study |
| title_sort | associations between maternal and fetal exposure to endocrine disrupting chemicals and asymmetric fetal growth restriction a prospective cohort study |
| topic | endocrine disruptors bisphenol-A monoethyl phthalates perfluorooctanoic acid fetal growth restriction placental insufficiency |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1351786/full |
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