Thrombocytopenia as a Clinical Biomarker of Retinopathy of Prematurity
Highlights: • This is the first systematic review investigating thrombocytopenia and its association with retinopathy of prematurity. • Thrombocytopenia can be a useful clinical biomarker in retinopathy of prematurity screening, considering the quick, affordable, and widespread availability of th...
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| Format: | Article |
| Language: | English |
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Universitas Airlangga
2023-12-01
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| Series: | Folia Medica Indonesiana |
| Subjects: | |
| Online Access: | https://e-journal.unair.ac.id/FMI/article/view/42970 |
| _version_ | 1797253991078297600 |
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| author | I Wayan Eka Sutyawan Ni Made Ayu Surasmiati Putu Anindya Agrasidi Priscilla Dwianggita Stephanus Anggara Anggara |
| author_facet | I Wayan Eka Sutyawan Ni Made Ayu Surasmiati Putu Anindya Agrasidi Priscilla Dwianggita Stephanus Anggara Anggara |
| author_sort | I Wayan Eka Sutyawan |
| collection | DOAJ |
| description | Highlights:
• This is the first systematic review investigating thrombocytopenia and its association with retinopathy of prematurity.
• Thrombocytopenia can be a useful clinical biomarker in retinopathy of prematurity screening, considering the quick, affordable, and widespread availability of the examination.
Abstract
Retinopathy of prematurity (ROP) is the primary cause of childhood blindness. It arises from the underdevelopment of retinal blood vessels in premature infants. Platelets have a vital function in the regulation of angiogenesis. Thus, thrombocytopenia may contribute to the progression of ROP. The objective of this systematic study was to examine the relationship between thrombocytopenia and ROP. The PubMed and Cochrane Library databases were accessed to search for retrospective, case-control, and cross-sectional studies. This study adhered to the guidelines outlined by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The literature search resulted in nine records to be analyzed in our review. All the selected studies were conducted between 2017 and 2022. Seven studies reported that the prevalence of thrombocytopenia in infants with ROP ranged from 18.37% to 71%. The frequency of thrombocytopenia in preterm children without ROP was between 5.71% and 21%. Thrombocytopenia was identified as a risk factor for ROP in seven studies, with the odds ratio (OR) for thrombocytopenia ranging from 2.8 to 6.69. Thrombocytopenia in premature infants can potentially serve as a clinical biomarker in the screening of type 1 ROP. This finding suggests that thrombocytopenia may contribute to the pathophysiology of ROP. Further research is necessary to determine the critical threshold platelet count for thrombocytopenia in infants with ROP. |
| first_indexed | 2024-04-24T21:42:51Z |
| format | Article |
| id | doaj.art-a90a9d392fa147ca9ef073f7be5017d1 |
| institution | Directory Open Access Journal |
| issn | 2355-8393 2599-056X |
| language | English |
| last_indexed | 2024-04-24T21:42:51Z |
| publishDate | 2023-12-01 |
| publisher | Universitas Airlangga |
| record_format | Article |
| series | Folia Medica Indonesiana |
| spelling | doaj.art-a90a9d392fa147ca9ef073f7be5017d12024-03-21T05:20:11ZengUniversitas AirlanggaFolia Medica Indonesiana2355-83932599-056X2023-12-0159441041710.20473/fmi.v59i4.4297041052Thrombocytopenia as a Clinical Biomarker of Retinopathy of PrematurityI Wayan Eka Sutyawan0https://orcid.org/0000-0002-0649-3438Ni Made Ayu Surasmiati1https://orcid.org/0000-0001-7835-224XPutu Anindya Agrasidi2https://orcid.org/0000-0001-7923-7294Priscilla Dwianggita3https://orcid.org/0000-0003-3817-6338Stephanus Anggara Anggara4https://orcid.org/0000-0002-7829-3830Department of Ophthalmology, Faculty of Medicine, Universitas Udayana, Prof. Dr. IGNG Ngoerah Central General Hospital, Denpasar, IndonesiaDepartment of Ophthalmology, Faculty of Medicine, Universitas Udayana, Prof. Dr. IGNG Ngoerah Central General Hospital, Denpasar, IndonesiaDepartment of Ophthalmology, Faculty of Medicine, Universitas Udayana, Prof. Dr. IGNG Ngoerah Central General Hospital, Denpasar, IndonesiaDepartment of Ophthalmology, Faculty of Medicine, Udayana University, Sanglah Hospital Denpasar, Bali, Indonesia Department of Ophthalmology, Faculty of Medicine, Udayana University, Sanglah Hospital Denpasar, Bali, IndonesiaHighlights: • This is the first systematic review investigating thrombocytopenia and its association with retinopathy of prematurity. • Thrombocytopenia can be a useful clinical biomarker in retinopathy of prematurity screening, considering the quick, affordable, and widespread availability of the examination. Abstract Retinopathy of prematurity (ROP) is the primary cause of childhood blindness. It arises from the underdevelopment of retinal blood vessels in premature infants. Platelets have a vital function in the regulation of angiogenesis. Thus, thrombocytopenia may contribute to the progression of ROP. The objective of this systematic study was to examine the relationship between thrombocytopenia and ROP. The PubMed and Cochrane Library databases were accessed to search for retrospective, case-control, and cross-sectional studies. This study adhered to the guidelines outlined by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The literature search resulted in nine records to be analyzed in our review. All the selected studies were conducted between 2017 and 2022. Seven studies reported that the prevalence of thrombocytopenia in infants with ROP ranged from 18.37% to 71%. The frequency of thrombocytopenia in preterm children without ROP was between 5.71% and 21%. Thrombocytopenia was identified as a risk factor for ROP in seven studies, with the odds ratio (OR) for thrombocytopenia ranging from 2.8 to 6.69. Thrombocytopenia in premature infants can potentially serve as a clinical biomarker in the screening of type 1 ROP. This finding suggests that thrombocytopenia may contribute to the pathophysiology of ROP. Further research is necessary to determine the critical threshold platelet count for thrombocytopenia in infants with ROP.https://e-journal.unair.ac.id/FMI/article/view/42970thrombocytopeniaretinopathy of prematuritypreterm infantangiogenesischildbirth complications |
| spellingShingle | I Wayan Eka Sutyawan Ni Made Ayu Surasmiati Putu Anindya Agrasidi Priscilla Dwianggita Stephanus Anggara Anggara Thrombocytopenia as a Clinical Biomarker of Retinopathy of Prematurity Folia Medica Indonesiana thrombocytopenia retinopathy of prematurity preterm infant angiogenesis childbirth complications |
| title | Thrombocytopenia as a Clinical Biomarker of Retinopathy of Prematurity |
| title_full | Thrombocytopenia as a Clinical Biomarker of Retinopathy of Prematurity |
| title_fullStr | Thrombocytopenia as a Clinical Biomarker of Retinopathy of Prematurity |
| title_full_unstemmed | Thrombocytopenia as a Clinical Biomarker of Retinopathy of Prematurity |
| title_short | Thrombocytopenia as a Clinical Biomarker of Retinopathy of Prematurity |
| title_sort | thrombocytopenia as a clinical biomarker of retinopathy of prematurity |
| topic | thrombocytopenia retinopathy of prematurity preterm infant angiogenesis childbirth complications |
| url | https://e-journal.unair.ac.id/FMI/article/view/42970 |
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